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O00175

- CCL24_HUMAN

UniProt

O00175 - CCL24_HUMAN

Protein

C-C motif chemokine 24

Gene

CCL24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

    GO - Molecular functioni

    1. chemokine activity Source: UniProtKB

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. chemotaxis Source: ProtInc
    3. cytoskeleton organization Source: UniProtKB
    4. eosinophil chemotaxis Source: UniProtKB
    5. immune response Source: ProtInc
    6. inflammatory response Source: ProtInc
    7. positive regulation of actin filament polymerization Source: BHF-UCL
    8. positive regulation of angiogenesis Source: Ensembl
    9. positive regulation of cell migration Source: BHF-UCL
    10. positive regulation of endothelial cell proliferation Source: BHF-UCL
    11. positive regulation of eosinophil migration Source: Ensembl
    12. positive regulation of inflammatory response Source: Ensembl
    13. positive regulation of Rac GTPase activity Source: BHF-UCL
    14. regulation of cell shape Source: UniProtKB
    15. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 24
    Alternative name(s):
    CK-beta-6
    Eosinophil chemotactic protein 2
    Eotaxin-2
    Myeloid progenitor inhibitory factor 2
    Short name:
    MPIF-2
    Small-inducible cytokine A24
    Gene namesi
    Name:CCL24
    Synonyms:MPIF2, SCYA24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:10623. CCL24.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35555.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26263 PublicationsAdd
    BLAST
    Chaini27 – 11993C-C motif chemokine 24PRO_0000005232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 58
    Disulfide bondi34 ↔ 74
    Glycosylationi115 – 1151N-linked (GlcNAc...)

    Post-translational modificationi

    N-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO00175.
    PRIDEiO00175.

    Miscellaneous databases

    PMAP-CutDBO00175.

    Expressioni

    Tissue specificityi

    Activated monocytes and activated T lymphocytes.

    Gene expression databases

    BgeeiO00175.
    CleanExiHS_CCL24.
    GenevestigatoriO00175.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5876N.
    MINTiMINT-105313.
    STRINGi9606.ENSP00000222902.

    Structurei

    Secondary structure

    1
    119
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 373
    Turni44 – 463
    Beta strandi47 – 526
    Beta strandi56 – 605
    Beta strandi63 – 675
    Beta strandi73 – 753
    Helixi80 – 9213

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EIGNMR-A27-99[»]
    1EIHNMR-A27-99[»]
    ProteinModelPortaliO00175.
    SMRiO00175. Positions 27-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO00175.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41621.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiO00175.
    KOiK05514.
    OMAiFCGDPKQ.
    OrthoDBiEOG73BVG4.
    PhylomeDBiO00175.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O00175-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLMTIVTS LLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY    50
    QLSSRSTCLK AGVIFTTKKG QQFCGDPKQE WVQRYMKNLD AKQKKASPRA 100
    RAVAVKGPVQ RYPGNQTTC 119
    Length:119
    Mass (Da):13,134
    Last modified:May 30, 2000 - v2
    Checksum:i6CAACA61731FB393
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611A → G in AAB51135. (PubMed:9104803)Curated
    Sequence conflicti73 – 731F → S AA sequence (PubMed:9104803)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291I → L.1 Publication
    Corresponds to variant rs2302006 [ dbSNP | Ensembl ].
    VAR_018404
    Natural varianti31 – 311S → F.
    Corresponds to variant rs11465293 [ dbSNP | Ensembl ].
    VAR_048710
    Natural varianti102 – 1021A → T.
    Corresponds to variant rs11465312 [ dbSNP | Ensembl ].
    VAR_048711
    Natural varianti110 – 1101Q → E.
    Corresponds to variant rs11465313 [ dbSNP | Ensembl ].
    VAR_048712

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85768 mRNA. Translation: AAB51135.1.
    AK312216 mRNA. Translation: BAG35149.1.
    AC005102 Genomic DNA. Translation: AAD15410.1.
    BC069072 mRNA. Translation: AAH69072.1.
    BC069391 mRNA. Translation: AAH69391.1.
    AJ223461 mRNA. Translation: CAA11383.1.
    CCDSiCCDS34670.1.
    RefSeqiNP_002982.2. NM_002991.2.
    UniGeneiHs.247838.

    Genome annotation databases

    EnsembliENST00000222902; ENSP00000222902; ENSG00000106178.
    ENST00000416943; ENSP00000400533; ENSG00000106178.
    GeneIDi6369.
    KEGGihsa:6369.
    UCSCiuc011kga.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL24 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85768 mRNA. Translation: AAB51135.1 .
    AK312216 mRNA. Translation: BAG35149.1 .
    AC005102 Genomic DNA. Translation: AAD15410.1 .
    BC069072 mRNA. Translation: AAH69072.1 .
    BC069391 mRNA. Translation: AAH69391.1 .
    AJ223461 mRNA. Translation: CAA11383.1 .
    CCDSi CCDS34670.1.
    RefSeqi NP_002982.2. NM_002991.2.
    UniGenei Hs.247838.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EIG NMR - A 27-99 [» ]
    1EIH NMR - A 27-99 [» ]
    ProteinModelPortali O00175.
    SMRi O00175. Positions 27-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5876N.
    MINTi MINT-105313.
    STRINGi 9606.ENSP00000222902.

    Proteomic databases

    PaxDbi O00175.
    PRIDEi O00175.

    Protocols and materials databases

    DNASUi 6369.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222902 ; ENSP00000222902 ; ENSG00000106178 .
    ENST00000416943 ; ENSP00000400533 ; ENSG00000106178 .
    GeneIDi 6369.
    KEGGi hsa:6369.
    UCSCi uc011kga.2. human.

    Organism-specific databases

    CTDi 6369.
    GeneCardsi GC07M075440.
    HGNCi HGNC:10623. CCL24.
    MIMi 602495. gene.
    neXtProti NX_O00175.
    PharmGKBi PA35555.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41621.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi O00175.
    KOi K05514.
    OMAi FCGDPKQ.
    OrthoDBi EOG73BVG4.
    PhylomeDBi O00175.
    TreeFami TF334888.

    Miscellaneous databases

    EvolutionaryTracei O00175.
    GenomeRNAii 6369.
    NextBioi 24748.
    PMAP-CutDB O00175.
    PROi O00175.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00175.
    CleanExi HS_CCL24.
    Genevestigatori O00175.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors."
      Patel V.P., Kreider B.L., Li Y., Li H., Leung K., Salcedo T., Nardelli B., Pippalla V., Gentz S., Thotakura R., Parmelee D., Gentz R., Garotta G.
      J. Exp. Med. 185:1163-1172(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-41 AND 73.
      Tissue: Monocyte.
    2. "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils."
      White J.R., Imburgia C., Dul E., Appelbaum E., O'Donnell K., O'Shannessy D.J., Brawner M., Fornwald J., Adamou J., Elshourbagy N.A., Kaiser K., Foley J.J., Schmidt D.B., Johanson K., Macphee C., Moores K., McNulty D., Scott G.F., Schleimer R.P., Sarau H.M.
      J. Leukoc. Biol. 62:667-675(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
      Tissue: Monocyte.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-29.
      Tissue: Colon.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "cDNA, genomic organisation and chromosomal location of the MPIF-2 (eotaxin-2) gene."
      Hein H., Theran L.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-117.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-41.
    8. "NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2."
      Mayer K.L., Stone M.J.
      Biochemistry 39:8382-8395(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiCCL24_HUMAN
    AccessioniPrimary (citable) accession number: O00175
    Secondary accession number(s): B2R5K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3