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Protein

C-C motif chemokine 24

Gene

CCL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • cytoskeleton organization Source: UniProtKB
  • eosinophil chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
  • lymphocyte chemotaxis Source: GO_Central
  • monocyte chemotaxis Source: GO_Central
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of actin filament polymerization Source: BHF-UCL
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of eosinophil migration Source: Ensembl
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: BHF-UCL
  • positive regulation of inflammatory response Source: GO_Central
  • regulation of cell shape Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
CK-beta-6
Eosinophil chemotactic protein 2
Eotaxin-2
Myeloid progenitor inhibitory factor 2
Short name:
MPIF-2
Small-inducible cytokine A24
Gene namesi
Name:CCL24
Synonyms:MPIF2, SCYA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:10623. CCL24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6369.
OpenTargetsiENSG00000106178.
PharmGKBiPA35555.

Polymorphism and mutation databases

BioMutaiCCL24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 263 PublicationsAdd BLAST26
ChainiPRO_000000523227 – 119C-C motif chemokine 24Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 58
Disulfide bondi34 ↔ 74
Glycosylationi115N-linked (GlcNAc...)1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00175.
PeptideAtlasiO00175.
PRIDEiO00175.

Miscellaneous databases

PMAP-CutDBO00175.

Expressioni

Tissue specificityi

Activated monocytes and activated T lymphocytes.

Gene expression databases

BgeeiENSG00000106178.
CleanExiHS_CCL24.
GenevisibleiO00175. HS.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-5876N.
MINTiMINT-105313.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 37Combined sources3
Turni44 – 46Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi56 – 60Combined sources5
Beta strandi63 – 67Combined sources5
Beta strandi73 – 75Combined sources3
Helixi80 – 92Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EIGNMR-A27-99[»]
1EIHNMR-A27-99[»]
ProteinModelPortaliO00175.
SMRiO00175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00175.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCGF. Eukaryota.
ENOG41119KC. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00175.
KOiK05514.
OMAiSSCCMSF.
OrthoDBiEOG091G1251.
PhylomeDBiO00175.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLMTIVTS LLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY
60 70 80 90 100
QLSSRSTCLK AGVIFTTKKG QQFCGDPKQE WVQRYMKNLD AKQKKASPRA
110
RAVAVKGPVQ RYPGNQTTC
Length:119
Mass (Da):13,134
Last modified:May 30, 2000 - v2
Checksum:i6CAACA61731FB393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61A → G in AAB51135 (PubMed:9104803).Curated1
Sequence conflicti73F → S AA sequence (PubMed:9104803).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01840429I → L.1 PublicationCorresponds to variant rs2302006dbSNPEnsembl.1
Natural variantiVAR_04871031S → F.Corresponds to variant rs11465293dbSNPEnsembl.1
Natural variantiVAR_048711102A → T.Corresponds to variant rs11465312dbSNPEnsembl.1
Natural variantiVAR_048712110Q → E.Corresponds to variant rs11465313dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85768 mRNA. Translation: AAB51135.1.
AK312216 mRNA. Translation: BAG35149.1.
AC005102 Genomic DNA. Translation: AAD15410.1.
BC069072 mRNA. Translation: AAH69072.1.
BC069391 mRNA. Translation: AAH69391.1.
AJ223461 mRNA. Translation: CAA11383.1.
CCDSiCCDS34670.1.
RefSeqiNP_002982.2. NM_002991.2.
XP_011514761.1. XM_011516459.2.
XP_011514762.1. XM_011516460.2.
UniGeneiHs.247838.

Genome annotation databases

EnsembliENST00000222902; ENSP00000222902; ENSG00000106178.
ENST00000416943; ENSP00000400533; ENSG00000106178.
GeneIDi6369.
KEGGihsa:6369.
UCSCiuc011kga.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL24 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85768 mRNA. Translation: AAB51135.1.
AK312216 mRNA. Translation: BAG35149.1.
AC005102 Genomic DNA. Translation: AAD15410.1.
BC069072 mRNA. Translation: AAH69072.1.
BC069391 mRNA. Translation: AAH69391.1.
AJ223461 mRNA. Translation: CAA11383.1.
CCDSiCCDS34670.1.
RefSeqiNP_002982.2. NM_002991.2.
XP_011514761.1. XM_011516459.2.
XP_011514762.1. XM_011516460.2.
UniGeneiHs.247838.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EIGNMR-A27-99[»]
1EIHNMR-A27-99[»]
ProteinModelPortaliO00175.
SMRiO00175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5876N.
MINTiMINT-105313.

Polymorphism and mutation databases

BioMutaiCCL24.

Proteomic databases

PaxDbiO00175.
PeptideAtlasiO00175.
PRIDEiO00175.

Protocols and materials databases

DNASUi6369.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222902; ENSP00000222902; ENSG00000106178.
ENST00000416943; ENSP00000400533; ENSG00000106178.
GeneIDi6369.
KEGGihsa:6369.
UCSCiuc011kga.3. human.

Organism-specific databases

CTDi6369.
DisGeNETi6369.
GeneCardsiCCL24.
HGNCiHGNC:10623. CCL24.
MIMi602495. gene.
neXtProtiNX_O00175.
OpenTargetsiENSG00000106178.
PharmGKBiPA35555.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCGF. Eukaryota.
ENOG41119KC. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00175.
KOiK05514.
OMAiSSCCMSF.
OrthoDBiEOG091G1251.
PhylomeDBiO00175.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106178-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO00175.
GenomeRNAii6369.
PMAP-CutDBO00175.
PROiO00175.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106178.
CleanExiHS_CCL24.
GenevisibleiO00175. HS.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCL24_HUMAN
AccessioniPrimary (citable) accession number: O00175
Secondary accession number(s): B2R5K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.