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O00175

- CCL24_HUMAN

UniProt

O00175 - CCL24_HUMAN

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Protein

C-C motif chemokine 24

Gene

CCL24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

GO - Molecular functioni

  1. chemokine activity Source: UniProtKB

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. chemotaxis Source: ProtInc
  3. cytoskeleton organization Source: UniProtKB
  4. eosinophil chemotaxis Source: UniProtKB
  5. immune response Source: ProtInc
  6. inflammatory response Source: ProtInc
  7. positive regulation of actin filament polymerization Source: BHF-UCL
  8. positive regulation of angiogenesis Source: Ensembl
  9. positive regulation of cell migration Source: BHF-UCL
  10. positive regulation of endothelial cell proliferation Source: BHF-UCL
  11. positive regulation of eosinophil migration Source: Ensembl
  12. positive regulation of inflammatory response Source: Ensembl
  13. positive regulation of Rac GTPase activity Source: BHF-UCL
  14. regulation of cell shape Source: UniProtKB
  15. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
CK-beta-6
Eosinophil chemotactic protein 2
Eotaxin-2
Myeloid progenitor inhibitory factor 2
Short name:
MPIF-2
Small-inducible cytokine A24
Gene namesi
Name:CCL24
Synonyms:MPIF2, SCYA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:10623. CCL24.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26263 PublicationsAdd
BLAST
Chaini27 – 11993C-C motif chemokine 24PRO_0000005232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 58
Disulfide bondi34 ↔ 74
Glycosylationi115 – 1151N-linked (GlcNAc...)

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00175.
PRIDEiO00175.

Miscellaneous databases

PMAP-CutDBO00175.

Expressioni

Tissue specificityi

Activated monocytes and activated T lymphocytes.

Gene expression databases

BgeeiO00175.
CleanExiHS_CCL24.
GenevestigatoriO00175.

Interactioni

Protein-protein interaction databases

DIPiDIP-5876N.
MINTiMINT-105313.
STRINGi9606.ENSP00000222902.

Structurei

Secondary structure

1
119
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 373Combined sources
Turni44 – 463Combined sources
Beta strandi47 – 526Combined sources
Beta strandi56 – 605Combined sources
Beta strandi63 – 675Combined sources
Beta strandi73 – 753Combined sources
Helixi80 – 9213Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EIGNMR-A27-99[»]
1EIHNMR-A27-99[»]
ProteinModelPortaliO00175.
SMRiO00175. Positions 27-99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00175.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41621.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00175.
KOiK05514.
OMAiFCGDPKQ.
OrthoDBiEOG73BVG4.
PhylomeDBiO00175.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00175-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGLMTIVTS LLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY
60 70 80 90 100
QLSSRSTCLK AGVIFTTKKG QQFCGDPKQE WVQRYMKNLD AKQKKASPRA
110
RAVAVKGPVQ RYPGNQTTC
Length:119
Mass (Da):13,134
Last modified:May 30, 2000 - v2
Checksum:i6CAACA61731FB393
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611A → G in AAB51135. (PubMed:9104803)Curated
Sequence conflicti73 – 731F → S AA sequence (PubMed:9104803)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291I → L.1 Publication
Corresponds to variant rs2302006 [ dbSNP | Ensembl ].
VAR_018404
Natural varianti31 – 311S → F.
Corresponds to variant rs11465293 [ dbSNP | Ensembl ].
VAR_048710
Natural varianti102 – 1021A → T.
Corresponds to variant rs11465312 [ dbSNP | Ensembl ].
VAR_048711
Natural varianti110 – 1101Q → E.
Corresponds to variant rs11465313 [ dbSNP | Ensembl ].
VAR_048712

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85768 mRNA. Translation: AAB51135.1.
AK312216 mRNA. Translation: BAG35149.1.
AC005102 Genomic DNA. Translation: AAD15410.1.
BC069072 mRNA. Translation: AAH69072.1.
BC069391 mRNA. Translation: AAH69391.1.
AJ223461 mRNA. Translation: CAA11383.1.
CCDSiCCDS34670.1.
RefSeqiNP_002982.2. NM_002991.2.
UniGeneiHs.247838.

Genome annotation databases

EnsembliENST00000222902; ENSP00000222902; ENSG00000106178.
ENST00000416943; ENSP00000400533; ENSG00000106178.
GeneIDi6369.
KEGGihsa:6369.
UCSCiuc011kga.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL24 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85768 mRNA. Translation: AAB51135.1 .
AK312216 mRNA. Translation: BAG35149.1 .
AC005102 Genomic DNA. Translation: AAD15410.1 .
BC069072 mRNA. Translation: AAH69072.1 .
BC069391 mRNA. Translation: AAH69391.1 .
AJ223461 mRNA. Translation: CAA11383.1 .
CCDSi CCDS34670.1.
RefSeqi NP_002982.2. NM_002991.2.
UniGenei Hs.247838.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EIG NMR - A 27-99 [» ]
1EIH NMR - A 27-99 [» ]
ProteinModelPortali O00175.
SMRi O00175. Positions 27-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5876N.
MINTi MINT-105313.
STRINGi 9606.ENSP00000222902.

Proteomic databases

PaxDbi O00175.
PRIDEi O00175.

Protocols and materials databases

DNASUi 6369.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222902 ; ENSP00000222902 ; ENSG00000106178 .
ENST00000416943 ; ENSP00000400533 ; ENSG00000106178 .
GeneIDi 6369.
KEGGi hsa:6369.
UCSCi uc011kga.2. human.

Organism-specific databases

CTDi 6369.
GeneCardsi GC07M075440.
HGNCi HGNC:10623. CCL24.
MIMi 602495. gene.
neXtProti NX_O00175.
PharmGKBi PA35555.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41621.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi O00175.
KOi K05514.
OMAi FCGDPKQ.
OrthoDBi EOG73BVG4.
PhylomeDBi O00175.
TreeFami TF334888.

Miscellaneous databases

EvolutionaryTracei O00175.
GenomeRNAii 6369.
NextBioi 24748.
PMAP-CutDB O00175.
PROi O00175.
SOURCEi Search...

Gene expression databases

Bgeei O00175.
CleanExi HS_CCL24.
Genevestigatori O00175.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors."
    Patel V.P., Kreider B.L., Li Y., Li H., Leung K., Salcedo T., Nardelli B., Pippalla V., Gentz S., Thotakura R., Parmelee D., Gentz R., Garotta G.
    J. Exp. Med. 185:1163-1172(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-41 AND 73.
    Tissue: Monocyte.
  2. "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils."
    White J.R., Imburgia C., Dul E., Appelbaum E., O'Donnell K., O'Shannessy D.J., Brawner M., Fornwald J., Adamou J., Elshourbagy N.A., Kaiser K., Foley J.J., Schmidt D.B., Johanson K., Macphee C., Moores K., McNulty D., Scott G.F., Schleimer R.P., Sarau H.M.
    J. Leukoc. Biol. 62:667-675(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Monocyte.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-29.
    Tissue: Colon.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "cDNA, genomic organisation and chromosomal location of the MPIF-2 (eotaxin-2) gene."
    Hein H., Theran L.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-117.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-41.
  8. "NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2."
    Mayer K.L., Stone M.J.
    Biochemistry 39:8382-8395(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCCL24_HUMAN
AccessioniPrimary (citable) accession number: O00175
Secondary accession number(s): B2R5K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3