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Protein

C-C motif chemokine 24

Gene

CCL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • chemotaxis Source: ProtInc
  • cytoskeleton organization Source: UniProtKB
  • eosinophil chemotaxis Source: UniProtKB
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
  • positive regulation of actin filament polymerization Source: BHF-UCL
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of eosinophil migration Source: Ensembl
  • positive regulation of GTPase activity Source: BHF-UCL
  • positive regulation of inflammatory response Source: Ensembl
  • regulation of cell shape Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
CK-beta-6
Eosinophil chemotactic protein 2
Eotaxin-2
Myeloid progenitor inhibitory factor 2
Short name:
MPIF-2
Small-inducible cytokine A24
Gene namesi
Name:CCL24
Synonyms:MPIF2, SCYA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:10623. CCL24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35555.

Polymorphism and mutation databases

BioMutaiCCL24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26263 PublicationsAdd
BLAST
Chaini27 – 11993C-C motif chemokine 24PRO_0000005232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 58
Disulfide bondi34 ↔ 74
Glycosylationi115 – 1151N-linked (GlcNAc...)

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00175.
PRIDEiO00175.

Miscellaneous databases

PMAP-CutDBO00175.

Expressioni

Tissue specificityi

Activated monocytes and activated T lymphocytes.

Gene expression databases

BgeeiO00175.
CleanExiHS_CCL24.
GenevisibleiO00175. HS.

Interactioni

Protein-protein interaction databases

DIPiDIP-5876N.
MINTiMINT-105313.

Structurei

Secondary structure

1
119
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 373Combined sources
Turni44 – 463Combined sources
Beta strandi47 – 526Combined sources
Beta strandi56 – 605Combined sources
Beta strandi63 – 675Combined sources
Beta strandi73 – 753Combined sources
Helixi80 – 9213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EIGNMR-A27-99[»]
1EIHNMR-A27-99[»]
ProteinModelPortaliO00175.
SMRiO00175. Positions 27-99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00175.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41621.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00175.
KOiK05514.
OMAiFCGDPKQ.
OrthoDBiEOG73BVG4.
PhylomeDBiO00175.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLMTIVTS LLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY
60 70 80 90 100
QLSSRSTCLK AGVIFTTKKG QQFCGDPKQE WVQRYMKNLD AKQKKASPRA
110
RAVAVKGPVQ RYPGNQTTC
Length:119
Mass (Da):13,134
Last modified:May 30, 2000 - v2
Checksum:i6CAACA61731FB393
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611A → G in AAB51135 (PubMed:9104803).Curated
Sequence conflicti73 – 731F → S AA sequence (PubMed:9104803).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291I → L.1 Publication
Corresponds to variant rs2302006 [ dbSNP | Ensembl ].
VAR_018404
Natural varianti31 – 311S → F.
Corresponds to variant rs11465293 [ dbSNP | Ensembl ].
VAR_048710
Natural varianti102 – 1021A → T.
Corresponds to variant rs11465312 [ dbSNP | Ensembl ].
VAR_048711
Natural varianti110 – 1101Q → E.
Corresponds to variant rs11465313 [ dbSNP | Ensembl ].
VAR_048712

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85768 mRNA. Translation: AAB51135.1.
AK312216 mRNA. Translation: BAG35149.1.
AC005102 Genomic DNA. Translation: AAD15410.1.
BC069072 mRNA. Translation: AAH69072.1.
BC069391 mRNA. Translation: AAH69391.1.
AJ223461 mRNA. Translation: CAA11383.1.
CCDSiCCDS34670.1.
RefSeqiNP_002982.2. NM_002991.2.
UniGeneiHs.247838.

Genome annotation databases

EnsembliENST00000222902; ENSP00000222902; ENSG00000106178.
ENST00000416943; ENSP00000400533; ENSG00000106178.
GeneIDi6369.
KEGGihsa:6369.
UCSCiuc011kga.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL24 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85768 mRNA. Translation: AAB51135.1.
AK312216 mRNA. Translation: BAG35149.1.
AC005102 Genomic DNA. Translation: AAD15410.1.
BC069072 mRNA. Translation: AAH69072.1.
BC069391 mRNA. Translation: AAH69391.1.
AJ223461 mRNA. Translation: CAA11383.1.
CCDSiCCDS34670.1.
RefSeqiNP_002982.2. NM_002991.2.
UniGeneiHs.247838.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EIGNMR-A27-99[»]
1EIHNMR-A27-99[»]
ProteinModelPortaliO00175.
SMRiO00175. Positions 27-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5876N.
MINTiMINT-105313.

Polymorphism and mutation databases

BioMutaiCCL24.

Proteomic databases

PaxDbiO00175.
PRIDEiO00175.

Protocols and materials databases

DNASUi6369.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222902; ENSP00000222902; ENSG00000106178.
ENST00000416943; ENSP00000400533; ENSG00000106178.
GeneIDi6369.
KEGGihsa:6369.
UCSCiuc011kga.2. human.

Organism-specific databases

CTDi6369.
GeneCardsiGC07M075440.
HGNCiHGNC:10623. CCL24.
MIMi602495. gene.
neXtProtiNX_O00175.
PharmGKBiPA35555.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41621.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO00175.
KOiK05514.
OMAiFCGDPKQ.
OrthoDBiEOG73BVG4.
PhylomeDBiO00175.
TreeFamiTF334888.

Miscellaneous databases

EvolutionaryTraceiO00175.
GenomeRNAii6369.
NextBioi24748.
PMAP-CutDBO00175.
PROiO00175.
SOURCEiSearch...

Gene expression databases

BgeeiO00175.
CleanExiHS_CCL24.
GenevisibleiO00175. HS.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors."
    Patel V.P., Kreider B.L., Li Y., Li H., Leung K., Salcedo T., Nardelli B., Pippalla V., Gentz S., Thotakura R., Parmelee D., Gentz R., Garotta G.
    J. Exp. Med. 185:1163-1172(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-41 AND 73.
    Tissue: Monocyte.
  2. "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils."
    White J.R., Imburgia C., Dul E., Appelbaum E., O'Donnell K., O'Shannessy D.J., Brawner M., Fornwald J., Adamou J., Elshourbagy N.A., Kaiser K., Foley J.J., Schmidt D.B., Johanson K., Macphee C., Moores K., McNulty D., Scott G.F., Schleimer R.P., Sarau H.M.
    J. Leukoc. Biol. 62:667-675(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Monocyte.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-29.
    Tissue: Colon.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "cDNA, genomic organisation and chromosomal location of the MPIF-2 (eotaxin-2) gene."
    Hein H., Theran L.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-117.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-41.
  8. "NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2."
    Mayer K.L., Stone M.J.
    Biochemistry 39:8382-8395(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCCL24_HUMAN
AccessioniPrimary (citable) accession number: O00175
Secondary accession number(s): B2R5K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 30, 2000
Last modified: June 24, 2015
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.