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Protein

AH receptor-interacting protein

Gene

AIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Cellular negative regulator of the hepatitis B virus (HBV) X protein.

GO - Molecular functioni

  • GAF domain binding Source: UniProtKB
  • signal transducer activity Source: ProtInc
  • transcription coactivator activity Source: ProtInc
  • transcription factor binding Source: ProtInc
  • unfolded protein binding Source: HGNC

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110711-MONOMER.
SIGNORiO00170.

Names & Taxonomyi

Protein namesi
Recommended name:
AH receptor-interacting protein
Short name:
AIP
Alternative name(s):
Aryl-hydrocarbon receptor-interacting protein
HBV X-associated protein 2
Short name:
XAP-2
Immunophilin homolog ARA9
Gene namesi
Name:AIP
Synonyms:XAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:358. AIP.

Subcellular locationi

GO - Cellular componenti

  • aryl hydrocarbon receptor complex Source: Ensembl
  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • membrane Source: Ensembl
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Pituitary adenoma, growth hormone-secreting, 1 (PAGH1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA growth hormone-secreting, benign neoplasm of the anterior pituitary gland, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.
See also OMIM:102200
ACTH-secreting pituitary adenoma (ASPA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA pituitary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
See also OMIM:219090
Prolactin-secreting pituitary adenoma (PSPA)1 Publication1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionMost common type of hormonally active pituitary adenoma.
See also OMIM:600634

Keywords - Diseasei

Cushing syndrome

Organism-specific databases

DisGeNETi9049.
MalaCardsiAIP.
MIMi102200. phenotype.
219090. phenotype.
600634. phenotype.
Orphaneti963. Acromegaly.
314777. Familial isolated pituitary adenoma.
PharmGKBiPA24652.

Polymorphism and mutation databases

BioMutaiAIP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000753391 – 330AH receptor-interacting proteinAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00170.
MaxQBiO00170.
PaxDbiO00170.
PeptideAtlasiO00170.
PRIDEiO00170.

PTM databases

iPTMnetiO00170.
PhosphoSitePlusiO00170.

Expressioni

Tissue specificityi

Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Gene expression databases

BgeeiENSG00000110711.
CleanExiHS_AIP.
ExpressionAtlasiO00170. baseline and differential.
GenevisibleiO00170. HS.

Organism-specific databases

HPAiCAB069477.
HPA004063.
HPA050217.

Interactioni

Subunit structurei

Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082383EBI-704197,EBI-352572
IRF7Q929852EBI-704197,EBI-968267
PDE2AO004086EBI-704197,EBI-1785967

GO - Molecular functioni

  • GAF domain binding Source: UniProtKB
  • transcription factor binding Source: ProtInc
  • unfolded protein binding Source: HGNC

Protein-protein interaction databases

BioGridi114511. 44 interactors.
DIPiDIP-34068N.
IntActiO00170. 31 interactors.
MINTiMINT-5000425.
STRINGi9606.ENSP00000279146.

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 9Combined sources6
Beta strandi17 – 19Combined sources3
Beta strandi33 – 37Combined sources5
Beta strandi39 – 41Combined sources3
Beta strandi43 – 46Combined sources4
Beta strandi49 – 53Combined sources5
Turni54 – 57Combined sources4
Beta strandi60 – 67Combined sources8
Helixi72 – 77Combined sources6
Beta strandi85 – 89Combined sources5
Helixi92 – 95Combined sources4
Helixi98 – 105Combined sources8
Helixi108 – 110Combined sources3
Turni113 – 117Combined sources5
Turni137 – 139Combined sources3
Helixi140 – 143Combined sources4
Beta strandi149 – 158Combined sources10
Turni160 – 162Combined sources3
Helixi173 – 176Combined sources4
Helixi178 – 192Combined sources15
Helixi195 – 213Combined sources19
Helixi221 – 243Combined sources23
Helixi248 – 260Combined sources13
Helixi265 – 277Combined sources13
Helixi281 – 294Combined sources14
Helixi296 – 298Combined sources3
Helixi299 – 311Combined sources13
Helixi314 – 324Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LKNNMR-A2-166[»]
4AIFX-ray2.01A/B172-315[»]
4APOX-ray1.90A/B166-330[»]
ProteinModelPortaliO00170.
SMRiO00170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 121PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST91
Repeati179 – 212TPR 1Add BLAST34
Repeati231 – 264TPR 2Add BLAST34
Repeati265 – 298TPR 3Add BLAST34

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0545. Eukaryota.
ENOG410YGYV. LUCA.
HOVERGENiHBG004198.
InParanoidiO00170.
KOiK17767.
OrthoDBiEOG091G0C69.
PhylomeDBiO00170.
TreeFamiTF314507.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR031208. AIP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11242:SF3. PTHR11242:SF3. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHYRT LHSDDEGTVL
60 70 80 90 100
DDSRARGKPM ELIIGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL
110 120 130 140 150
VAKSLRNIAV GKDPLEGQRH CCGVAQMREH SSLGHADLDA LQQNPQPLIF
160 170 180 190 200
HMEMLKVESP GTYQQDPWAM TDEEKAKAVP LIHQEGNRLY REGHVKEAAA
210 220 230 240 250
KYYDAIACLK NLQMKEQPGS PEWIQLDQQI TPLLLNYCQC KLVVEEYYEV
260 270 280 290 300
LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP
310 320 330
VVSRELQALE ARIRQKDEED KARFRGIFSH
Length:330
Mass (Da):37,636
Last modified:July 28, 2009 - v2
Checksum:i9302AA6D0F8D8F51
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04390816R → H.2 PublicationsCorresponds to variant rs145047094dbSNPEnsembl.1
Natural variantiVAR_05840747 – 54Missing in patients with pituitary adenoma; unknown pathological significance. 1 Publication8
Natural variantiVAR_043909228Q → K.Combined sources4 PublicationsCorresponds to variant rs641081dbSNPEnsembl.1
Natural variantiVAR_043910241K → E in patients with pituitary adenoma; unknown pathological significance. 1 Publication1
Natural variantiVAR_043911248Missing in a ACTH-secreting pituitary adenoma patient; unknown pathological significance. 1 Publication1
Natural variantiVAR_043912271R → W in patients with pituitary adenoma; unknown pathological significance. 1 Publication1
Natural variantiVAR_043913304R → Q in a ACTH-secreting pituitary adenoma patient. 1 Publication1
Natural variantiVAR_061545307Q → R.4 PublicationsCorresponds to variant rs4930199dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31913 mRNA. Translation: AAB39923.1.
U78521 mRNA. Translation: AAB59004.1.
AM236341 Genomic DNA. Translation: CAJ85657.1.
EF066502 Genomic DNA. Translation: ABK60081.1.
EF066504 Genomic DNA. Translation: ABK60082.1.
EF066505 Genomic DNA. Translation: ABK60083.1.
EF066510 Genomic DNA. Translation: ABK60084.1.
BC104827 mRNA. Translation: AAI04828.1.
BC104797 mRNA. Translation: AAI04798.1.
CCDSiCCDS8168.1.
RefSeqiNP_001289888.1. NM_001302959.1.
NP_001289889.1. NM_001302960.1.
NP_003968.3. NM_003977.3.
UniGeneiHs.412433.

Genome annotation databases

EnsembliENST00000279146; ENSP00000279146; ENSG00000110711.
GeneIDi9049.
KEGGihsa:9049.
UCSCiuc001olv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31913 mRNA. Translation: AAB39923.1.
U78521 mRNA. Translation: AAB59004.1.
AM236341 Genomic DNA. Translation: CAJ85657.1.
EF066502 Genomic DNA. Translation: ABK60081.1.
EF066504 Genomic DNA. Translation: ABK60082.1.
EF066505 Genomic DNA. Translation: ABK60083.1.
EF066510 Genomic DNA. Translation: ABK60084.1.
BC104827 mRNA. Translation: AAI04828.1.
BC104797 mRNA. Translation: AAI04798.1.
CCDSiCCDS8168.1.
RefSeqiNP_001289888.1. NM_001302959.1.
NP_001289889.1. NM_001302960.1.
NP_003968.3. NM_003977.3.
UniGeneiHs.412433.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LKNNMR-A2-166[»]
4AIFX-ray2.01A/B172-315[»]
4APOX-ray1.90A/B166-330[»]
ProteinModelPortaliO00170.
SMRiO00170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114511. 44 interactors.
DIPiDIP-34068N.
IntActiO00170. 31 interactors.
MINTiMINT-5000425.
STRINGi9606.ENSP00000279146.

PTM databases

iPTMnetiO00170.
PhosphoSitePlusiO00170.

Polymorphism and mutation databases

BioMutaiAIP.

Proteomic databases

EPDiO00170.
MaxQBiO00170.
PaxDbiO00170.
PeptideAtlasiO00170.
PRIDEiO00170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279146; ENSP00000279146; ENSG00000110711.
GeneIDi9049.
KEGGihsa:9049.
UCSCiuc001olv.4. human.

Organism-specific databases

CTDi9049.
DisGeNETi9049.
GeneCardsiAIP.
GeneReviewsiAIP.
HGNCiHGNC:358. AIP.
HPAiCAB069477.
HPA004063.
HPA050217.
MalaCardsiAIP.
MIMi102200. phenotype.
219090. phenotype.
600634. phenotype.
605555. gene.
neXtProtiNX_O00170.
Orphaneti963. Acromegaly.
314777. Familial isolated pituitary adenoma.
PharmGKBiPA24652.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0545. Eukaryota.
ENOG410YGYV. LUCA.
HOVERGENiHBG004198.
InParanoidiO00170.
KOiK17767.
OrthoDBiEOG091G0C69.
PhylomeDBiO00170.
TreeFamiTF314507.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110711-MONOMER.
SIGNORiO00170.

Miscellaneous databases

GeneWikiiAH_receptor-interacting_protein.
GenomeRNAii9049.
PROiO00170.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110711.
CleanExiHS_AIP.
ExpressionAtlasiO00170. baseline and differential.
GenevisibleiO00170. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR031208. AIP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11242:SF3. PTHR11242:SF3. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIP_HUMAN
AccessioniPrimary (citable) accession number: O00170
Secondary accession number(s): A0SZW3
, A0SZW4, A0SZW5, A0SZW6, Q2M3Q2, Q99606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.