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Protein

Synaptosomal-associated protein 23

Gene

SNAP23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  • histamine secretion by mast cell Source: UniProtKB
  • membrane fusion Source: ProtInc
  • neutrophil degranulation Source: Reactome
  • post-Golgi vesicle-mediated transport Source: ProtInc
  • protein transport Source: UniProtKB-KW
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • synaptic vesicle priming Source: GO_Central
  • vesicle targeting Source: ProtInc

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-421837 Clathrin derived vesicle budding
R-HSA-6798695 Neutrophil degranulation
SIGNORiO00161

Protein family/group databases

TCDBi1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 23
Short name:
SNAP-23
Alternative name(s):
Vesicle-membrane fusion protein SNAP-23
Gene namesi
Name:SNAP23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000092531.9
HGNCiHGNC:11131 SNAP23
MIMi602534 gene
neXtProtiNX_O00161

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi8773
OpenTargetsiENSG00000092531
PharmGKBiPA35979

Polymorphism and mutation databases

BioMutaiSNAP23

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135981 – 211Synaptosomal-associated protein 23Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources2 Publications1
Modified residuei5PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei23PhosphoserineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Lipidationi79S-palmitoyl cysteine1 Publication1
Lipidationi80S-palmitoyl cysteine1 Publication1
Lipidationi83S-palmitoyl cysteine1 Publication1
Lipidationi85S-palmitoyl cysteine1 Publication1
Lipidationi87S-palmitoyl cysteine1 Publication1
Modified residuei110PhosphoserineCombined sources1
Lipidationi112S-palmitoyl cysteine1 Publication1
Modified residuei161PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiO00161
MaxQBiO00161
PaxDbiO00161
PeptideAtlasiO00161
PRIDEiO00161
ProteomicsDBi47748
47749 [O00161-2]

2D gel databases

OGPiO00161

PTM databases

iPTMnetiO00161
PhosphoSitePlusiO00161
SwissPalmiO00161

Miscellaneous databases

PMAP-CutDBiO00161

Expressioni

Tissue specificityi

Ubiquitous. Highest levels where found in placenta.

Gene expression databases

BgeeiENSG00000092531
CleanExiHS_SNAP23
ExpressionAtlasiO00161 baseline and differential
GenevisibleiO00161 HS

Organism-specific databases

HPAiCAB037083
CAB037317
HPA001214

Interactioni

Subunit structurei

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (PubMed:12556468). Found in a complex with VAMP8 and STX1A (PubMed:12130530). Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114303, 65 interactors
CORUMiO00161
IntActiO00161, 35 interactors
MINTiO00161
STRINGi9606.ENSP00000249647

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 74Combined sources51

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NHLX-ray2.30A23-76[»]
3ZUSX-ray2.95A/B/C/D150-209[»]
ProteinModelPortaliO00161
SMRiO00161
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00161

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 76t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd BLAST63
Domaini146 – 208t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 761 PublicationAdd BLAST54

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3065 Eukaryota
ENOG410Y3Y0 LUCA
GeneTreeiENSGT00390000012186
HOGENOMiHOG000231599
HOVERGENiHBG056971
InParanoidiO00161
KOiK08508
OMAiTNKDRID
OrthoDBiEOG091G0N7J
PhylomeDBiO00161
TreeFamiTF315125

Family and domain databases

InterProiView protein in InterPro
IPR000928 SNAP-25
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF00835 SNAP-25, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 2 hits
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform SNAP-23a (identifier: O00161-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE
60 70 80 90 100
QLNRIEEGLD QINKDMRETE KTLTELNKCC GLCVCPCNRT KNFESGKAYK
110 120 130 140 150
TTWGDGGENS PCNVVSKQPG PVTNGQLQQP TTGAASGGYI KRITNDARED
160 170 180 190 200
EMEENLTQVG SILGNLKDMA LNIGNEIDAQ NPQIKRITDK ADTNRDRIDI
210
ANARAKKLID S
Length:211
Mass (Da):23,354
Last modified:July 1, 1997 - v1
Checksum:iAC378E9786C3A239
GO
Isoform SNAP-23b (identifier: O00161-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: R → S
     90-142: Missing.

Show »
Length:158
Mass (Da):17,789
Checksum:i985F775F40884E07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135A → V in AAC50537 (PubMed:8663154).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00618789R → S in isoform SNAP-23b. 1 Publication1
Alternative sequenceiVSP_00618890 – 142Missing in isoform SNAP-23b. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55936 mRNA Translation: AAC50537.1
Y09567 mRNA Translation: CAA70760.1
Y09568 mRNA Translation: CAA70761.1
AJ011915 mRNA Translation: CAA09864.1
AJ278972, AJ278973, AJ278974 Genomic DNA Translation: CAC07504.1
BT006916 mRNA Translation: AAP35562.1
CR457212 mRNA Translation: CAG33493.1
BC000148 mRNA Translation: AAH00148.1
BC003686 mRNA Translation: AAH03686.1
BC022890 mRNA Translation: AAH22890.1
CCDSiCCDS10087.1 [O00161-1]
CCDS10088.1 [O00161-2]
PIRiJC5296
JC5297
RefSeqiNP_003816.2, NM_003825.3 [O00161-1]
NP_570710.1, NM_130798.2 [O00161-2]
UniGeneiHs.511149

Genome annotation databases

EnsembliENST00000249647; ENSP00000249647; ENSG00000092531 [O00161-1]
ENST00000349777; ENSP00000207062; ENSG00000092531 [O00161-2]
ENST00000397138; ENSP00000380327; ENSG00000092531 [O00161-2]
GeneIDi8773
KEGGihsa:8773
UCSCiuc001zpz.3 human [O00161-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNP23_HUMAN
AccessioniPrimary (citable) accession number: O00161
Secondary accession number(s): O00162, Q13602, Q6IAE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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