O00160 (MYO1F_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Unconventional myosin-If

Alternative name(s):
Myosin-Ie

Gene names

Name:

MYO1F

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1098 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments By similarity.
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain. Contains 1 SH3 domain.
Caution	Represents a unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	SH3 domain
Ligand	ATP-binding Actin-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to Gram-positive bacterium Inferred from electronic annotation. Source: Compara negative regulation of cell adhesion Inferred from electronic annotation. Source: Compara neutrophil degranulation Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara regulation of actin cytoskeleton organization Inferred from electronic annotation. Source: Compara regulation of innate immune response Inferred from electronic annotation. Source: Compara
Cellular_component	cortical actin cytoskeleton Inferred from electronic annotation. Source: Compara filamentous actin Inferred from electronic annotation. Source: Compara unconventional myosin complex Non-traceable author statement Ref.5. Source: UniProtKB
Molecular_function	ATP binding Non-traceable author statement Ref.5. Source: UniProtKB actin binding Non-traceable author statement Ref.5. Source: UniProtKB calmodulin binding Non-traceable author statement. Source: UniProtKB motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1098	1098	Unconventional myosin-If		PRO_0000123452
Regions
	Domain	1 – 677	677	Myosin head-like
	Domain	693 – 722	30	IQ
	Domain	1041 – 1098	58	SH3
	Nucleotide binding	110 – 117	8	ATP Potential
	Region	579 – 589	11	Actin-binding Potential
Amino acid modifications
	Modified residue	734	1	Phosphoserine By similarity
	Modified residue	1023	1	Phosphoserine Ref.6
Natural variations
	Natural variant	960	1	P → L. Corresponds to variant rs2288411 [ dbSNP | Ensembl ].		VAR_056179
Experimental info
	Sequence conflict	259	1	A → V in BAC03995. Ref.2
	Sequence conflict	534 – 536	3	TSE → SSD in CAA67058. Ref.5
	Sequence conflict	592 – 593	2	RP → HA in CAC83948. Ref.1
	Sequence conflict	592 – 593	2	RP → HA in CAA67058. Ref.5
	Sequence conflict	602	1	K → Q in CAA67058. Ref.5
	Sequence conflict	759	1	R → K in CAC83948. Ref.1
	Sequence conflict	759	1	R → K in CAA67058. Ref.5
	Sequence conflict	797	1	V → M in CAC83948. Ref.1
	Sequence conflict	797	1	V → M in CAA67058. Ref.5
	Sequence conflict	805	1	Q → P in CAA67058. Ref.5
	Sequence conflict	809	1	V → I in CAA67058. Ref.5
	Sequence conflict	814	1	V → L in CAA67058. Ref.5
	Sequence conflict	922	1	S → N in CAA67058. Ref.5
	Sequence conflict	927	1	R → G in CAA67058. Ref.5
	Sequence conflict	930	1	M → L in CAA67058. Ref.5
	Sequence conflict	948 – 951	4	APPR → GAPQ in CAA67058. Ref.5
	Sequence conflict	958 – 967	10	VPPSARGGPL → APLCPQGGAPC in CAA67058. Ref.5
	Sequence conflict	971 – 990	20	IMSGG…STSLG → KFIWPRGHPQASPALRPHPW D in CAA67058. Ref.5
	Sequence conflict	1031	1	Missing in CAA67058. Ref.5
	Sequence conflict	1090 – 1098	9	FPGNYVEKI → GSPSARSPA in BAC03995. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O00160 [UniParc]. Last modified November 24, 2009. Version 3. Checksum: 75C2B1306F74C7C5	FASTA	1,098	124,844
	10 20 30 40 50 60 MGSKERFHWQ SHNVKQSGVD DMVLLPQITE DAIAANLRKR FMDDYIFTYI GSVLISVNPF 70 80 90 100 110 120 KQMPYFTDRE IDLYQGAAQY ENPPHIYALT DNMYRNMLID CENQCVIISG ESGAGKTVAA 130 140 150 160 170 180 KYIMGYISKV SGGGEKVQHV KDIILQSNPL LEAFGNAKTV RNNNSSRFGK YFEIQFSRGG 190 200 210 220 230 240 EPDGGKISNF LLEKSRVVMQ NENERNFHIY YQLLEGASQE QRQNLGLMTP DYYYYLNQSD 250 260 270 280 290 300 TYQVDGTDDR SDFGETLSAM QVIGIPPSIQ QLVLQLVAGI LHLGNISFCE DGNYARVESV 310 320 330 340 350 360 DLLAFPAYLL GIDSGRLQEK LTSRKMDSRW GGRSESINVT LNVEQAAYTR DALAKGLYAR 370 380 390 400 410 420 LFDFLVEAIN RAMQKPQEEY SIGVLDIYGF EIFQKNGFEQ FCINFVNEKL QQIFIELTLK 430 440 450 460 470 480 AEQEEYVQEG IRWTPIQYFN NKVVCDLIEN KLSPPGIMSV LDDVCATMHA TGGGADQTLL 490 500 510 520 530 540 QKLQAAVGTH EHFNSWSAGF VIHHYAGKVS YDVSGFCERN RDVLFSDLIE LMQTSEQAFL 550 560 570 580 590 600 RMLFPEKLDG DKKGRPSTAG SKIKKQANDL VATLMRCTPH YIRCIKPNET KRPRDWEENR 610 620 630 640 650 660 VKHQVEYLGL KENIRVRRAG FAYRRQFAKF LQRYAILTPE TWPRWRGDER QGVQHLLRAV 670 680 690 700 710 720 NMEPDQYQMG STKVFVKNPE SLFLLEEVRE RKFDGFARTI QKAWRRHVAV RKYEEMREEA 730 740 750 760 770 780 SNILLNKKER RRNSINRNFV GDYLGLEERP ELRQFLGKRE RVDFADSVTK YDRRFKPIKR 790 800 810 820 830 840 DLILTPKCVY VIGREKVKKG PEKGQVCEVL KKKVDIQALR GVSLSTRQDD FFILQEDAAD 850 860 870 880 890 900 SFLESVFKTE FVSLLCKRFE EATRRPLPLT FSDTLQFRVK KEGWGGGGTR SVTFSRGFGD 910 920 930 940 950 960 LAVLKVGGRT LTVSVGDGLP KSSKPTRKGM AKGKPRRSSQ APTRAAPAPP RGMDRNGVPP 970 980 990 1000 1010 1020 SARGGPLPLE IMSGGGTHRP PRGPPSTSLG ASRRPRARPP SEHNTEFLNV PDQGMAGMQR 1030 1040 1050 1060 1070 1080 KRSVGQRPVP GVGRPKPQPR THGPRCRALY QYVGQDVDEL SFNVNEVIEI LMEDPSGWWK 1090 GRLHGQEGLF PGNYVEKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices." Krugmann S., Anderson K.E., Ridley S.H., Risso N., McGregor A., Coadwell J., Davidson K., Eguinoa A., Ellson C.D., Lipp P., Manifava M., Ktistakis N., Painter G., Thuring J.W., Cooper M.A., Lim Z.-Y., Holmes A.B., Dove S.K. , Michell R.H., Grewal A., Nazarian A., Erdjument-Bromage H., Tempst P., Stephens L.R., Hawkins P.T. Mol. Cell 9:95-108(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[5]	"Cloning of the genes encoding two murine and human cochlear unconventional type I myosins." Crozet F., El-Amraoui A., Blanchard S., Lenoir M., Ripoll C., Vago P., Hamel C., Fizames C., Levi-Acobas F., Depetris D., Mattei M.-G., Weil D., Pujol R., Petit C. Genomics 40:332-341(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-1098. Tissue: Retina.
[6]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1023, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ310570 mRNA. Translation: CAC83948.1. AK092877 mRNA. Translation: BAC03995.1. AC092298 Genomic DNA. No translation available. AC092316 Genomic DNA. No translation available. AC124902 Genomic DNA. No translation available. AC130469 Genomic DNA. No translation available. BC028071 mRNA. Translation: AAH28071.1. X98411 mRNA. Translation: CAA67058.1.
IPI	IPI00218638.
RefSeq	NP_036467.2. NM_012335.3.
UniGene	Hs.465818.
3D structure databases
ProteinModelPortal	O00160.
SMR	O00160. Positions 18-717, 1044-1098.
ModBase	Search...
Protein-protein interaction databases
IntAct	O00160. 2 interactions.
STRING	9606.ENSP00000344871.
PTM databases
PhosphoSite	O00160.
Proteomic databases
PaxDb	O00160.
PRIDE	O00160.
Protocols and materials databases
DNASU	4542.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338257; ENSP00000344871; ENSG00000142347. ENST00000572880; ENSP00000460038; ENSG00000262149.
GeneID	4542.
KEGG	hsa:4542.
UCSC	uc002mkg.3. human.
Organism-specific databases
CTD	4542.
GeneCards	GC19M008585.
H-InvDB	HIX0014717.
HGNC	HGNC:7600. MYO1F.
MIM	601480. gene.
neXtProt	NX_O00160.
PharmGKB	PA31402.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5022.
HOVERGEN	HBG100702.
KO	K10356.
OrthoDB	EOG49W2DM.
Gene expression databases
ArrayExpress	O00160.
Bgee	O00160.
CleanEx	HS_MYO1F.
Genevestigator	O00160.
GermOnline	ENSG00000142347. Homo sapiens.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR001609. Myosin_head_motor_dom. IPR010926. Myosin_tail_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00063. Myosin_head. 1 hit. PF06017. Myosin_TH1. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY. PR00452. SH3DOMAIN.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50096. IQ. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MYO1F. human.
GenomeRNAi	4542.
NextBio	17517.
SOURCE	Search...

Entry information

Entry name

MYO1F_HUMAN

Accession

Primary (citable) accession number: O00160
Secondary accession number(s): Q8WWN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 130 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.