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O00160

- MYO1F_HUMAN

UniProt

O00160 - MYO1F_HUMAN

Protein

Unconventional myosin-If

Gene

MYO1F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 3 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi110 – 1178ATPSequence Analysis

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. ATP binding Source: UniProtKB
    3. motor activity Source: InterPro

    GO - Biological processi

    1. defense response to Gram-positive bacterium Source: Ensembl
    2. negative regulation of cell adhesion Source: Ensembl
    3. neutrophil degranulation Source: Ensembl
    4. positive regulation of cell migration Source: Ensembl
    5. regulation of actin cytoskeleton organization Source: Ensembl
    6. regulation of innate immune response Source: Ensembl

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-If
    Alternative name(s):
    Myosin-Ie
    Gene namesi
    Name:MYO1F
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:7600. MYO1F.

    Subcellular locationi

    GO - Cellular componenti

    1. cortical actin cytoskeleton Source: Ensembl
    2. filamentous actin Source: Ensembl
    3. unconventional myosin complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31402.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10981098Unconventional myosin-IfPRO_0000123452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1023 – 10231Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO00160.
    PaxDbiO00160.
    PRIDEiO00160.

    PTM databases

    PhosphoSiteiO00160.

    Expressioni

    Gene expression databases

    ArrayExpressiO00160.
    BgeeiO00160.
    CleanExiHS_MYO1F.
    GenevestigatoriO00160.

    Organism-specific databases

    HPAiHPA055242.

    Interactioni

    Protein-protein interaction databases

    BioGridi110638. 8 interactions.
    IntActiO00160. 2 interactions.
    STRINGi9606.ENSP00000344871.

    Structurei

    3D structure databases

    ProteinModelPortaliO00160.
    SMRiO00160. Positions 18-717, 1044-1098.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 690674Myosin motorAdd
    BLAST
    Domaini693 – 72230IQPROSITE-ProRule annotationAdd
    BLAST
    Domaini1041 – 109858SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni579 – 58911Actin-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG5022.
    HOVERGENiHBG100702.
    KOiK10356.
    OMAiRRQFAKF.
    PhylomeDBiO00160.
    TreeFamiTF312960.

    Family and domain databases

    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    PR00452. SH3DOMAIN.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00160-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSKERFHWQ SHNVKQSGVD DMVLLPQITE DAIAANLRKR FMDDYIFTYI     50
    GSVLISVNPF KQMPYFTDRE IDLYQGAAQY ENPPHIYALT DNMYRNMLID 100
    CENQCVIISG ESGAGKTVAA KYIMGYISKV SGGGEKVQHV KDIILQSNPL 150
    LEAFGNAKTV RNNNSSRFGK YFEIQFSRGG EPDGGKISNF LLEKSRVVMQ 200
    NENERNFHIY YQLLEGASQE QRQNLGLMTP DYYYYLNQSD TYQVDGTDDR 250
    SDFGETLSAM QVIGIPPSIQ QLVLQLVAGI LHLGNISFCE DGNYARVESV 300
    DLLAFPAYLL GIDSGRLQEK LTSRKMDSRW GGRSESINVT LNVEQAAYTR 350
    DALAKGLYAR LFDFLVEAIN RAMQKPQEEY SIGVLDIYGF EIFQKNGFEQ 400
    FCINFVNEKL QQIFIELTLK AEQEEYVQEG IRWTPIQYFN NKVVCDLIEN 450
    KLSPPGIMSV LDDVCATMHA TGGGADQTLL QKLQAAVGTH EHFNSWSAGF 500
    VIHHYAGKVS YDVSGFCERN RDVLFSDLIE LMQTSEQAFL RMLFPEKLDG 550
    DKKGRPSTAG SKIKKQANDL VATLMRCTPH YIRCIKPNET KRPRDWEENR 600
    VKHQVEYLGL KENIRVRRAG FAYRRQFAKF LQRYAILTPE TWPRWRGDER 650
    QGVQHLLRAV NMEPDQYQMG STKVFVKNPE SLFLLEEVRE RKFDGFARTI 700
    QKAWRRHVAV RKYEEMREEA SNILLNKKER RRNSINRNFV GDYLGLEERP 750
    ELRQFLGKRE RVDFADSVTK YDRRFKPIKR DLILTPKCVY VIGREKVKKG 800
    PEKGQVCEVL KKKVDIQALR GVSLSTRQDD FFILQEDAAD SFLESVFKTE 850
    FVSLLCKRFE EATRRPLPLT FSDTLQFRVK KEGWGGGGTR SVTFSRGFGD 900
    LAVLKVGGRT LTVSVGDGLP KSSKPTRKGM AKGKPRRSSQ APTRAAPAPP 950
    RGMDRNGVPP SARGGPLPLE IMSGGGTHRP PRGPPSTSLG ASRRPRARPP 1000
    SEHNTEFLNV PDQGMAGMQR KRSVGQRPVP GVGRPKPQPR THGPRCRALY 1050
    QYVGQDVDEL SFNVNEVIEI LMEDPSGWWK GRLHGQEGLF PGNYVEKI 1098
    Length:1,098
    Mass (Da):124,844
    Last modified:November 24, 2009 - v3
    Checksum:i75C2B1306F74C7C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti259 – 2591A → V in BAC03995. (PubMed:14702039)Curated
    Sequence conflicti534 – 5363TSE → SSD in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti592 – 5932RP → HA in CAC83948. (PubMed:11804589)Curated
    Sequence conflicti592 – 5932RP → HA in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti602 – 6021K → Q in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti759 – 7591R → K in CAC83948. (PubMed:11804589)Curated
    Sequence conflicti759 – 7591R → K in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti797 – 7971V → M in CAC83948. (PubMed:11804589)Curated
    Sequence conflicti797 – 7971V → M in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti805 – 8051Q → P in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti809 – 8091V → I in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti814 – 8141V → L in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti922 – 9221S → N in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti927 – 9271R → G in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti930 – 9301M → L in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti948 – 9514APPR → GAPQ in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti958 – 96710VPPSARGGPL → APLCPQGGAPC in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti971 – 99020IMSGG…STSLG → KFIWPRGHPQASPALRPHPW D in CAA67058. (PubMed:9119401)CuratedAdd
    BLAST
    Sequence conflicti1031 – 10311Missing in CAA67058. (PubMed:9119401)Curated
    Sequence conflicti1090 – 10989FPGNYVEKI → GSPSARSPA in BAC03995. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti960 – 9601P → L.
    Corresponds to variant rs2288411 [ dbSNP | Ensembl ].
    VAR_056179

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310570 mRNA. Translation: CAC83948.1.
    AK092877 mRNA. Translation: BAC03995.1.
    AC092298 Genomic DNA. No translation available.
    AC092316 Genomic DNA. No translation available.
    AC124902 Genomic DNA. No translation available.
    AC130469 Genomic DNA. No translation available.
    BC028071 mRNA. Translation: AAH28071.1.
    X98411 mRNA. Translation: CAA67058.1.
    CCDSiCCDS42494.1.
    RefSeqiNP_036467.2. NM_012335.3.
    UniGeneiHs.465818.

    Genome annotation databases

    EnsembliENST00000338257; ENSP00000344871; ENSG00000142347.
    GeneIDi4542.
    KEGGihsa:4542.
    UCSCiuc002mkg.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310570 mRNA. Translation: CAC83948.1 .
    AK092877 mRNA. Translation: BAC03995.1 .
    AC092298 Genomic DNA. No translation available.
    AC092316 Genomic DNA. No translation available.
    AC124902 Genomic DNA. No translation available.
    AC130469 Genomic DNA. No translation available.
    BC028071 mRNA. Translation: AAH28071.1 .
    X98411 mRNA. Translation: CAA67058.1 .
    CCDSi CCDS42494.1.
    RefSeqi NP_036467.2. NM_012335.3.
    UniGenei Hs.465818.

    3D structure databases

    ProteinModelPortali O00160.
    SMRi O00160. Positions 18-717, 1044-1098.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110638. 8 interactions.
    IntActi O00160. 2 interactions.
    STRINGi 9606.ENSP00000344871.

    PTM databases

    PhosphoSitei O00160.

    Proteomic databases

    MaxQBi O00160.
    PaxDbi O00160.
    PRIDEi O00160.

    Protocols and materials databases

    DNASUi 4542.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338257 ; ENSP00000344871 ; ENSG00000142347 .
    GeneIDi 4542.
    KEGGi hsa:4542.
    UCSCi uc002mkg.3. human.

    Organism-specific databases

    CTDi 4542.
    GeneCardsi GC19M008585.
    H-InvDB HIX0014717.
    HGNCi HGNC:7600. MYO1F.
    HPAi HPA055242.
    MIMi 601480. gene.
    neXtProti NX_O00160.
    PharmGKBi PA31402.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOVERGENi HBG100702.
    KOi K10356.
    OMAi RRQFAKF.
    PhylomeDBi O00160.
    TreeFami TF312960.

    Miscellaneous databases

    ChiTaRSi MYO1F. human.
    GeneWikii MYO1F.
    GenomeRNAii 4542.
    NextBioi 17517.
    PROi O00160.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O00160.
    Bgeei O00160.
    CleanExi HS_MYO1F.
    Genevestigatori O00160.

    Family and domain databases

    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    PR00452. SH3DOMAIN.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    5. "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
      Crozet F., El-Amraoui A., Blanchard S., Lenoir M., Ripoll C., Vago P., Hamel C., Fizames C., Levi-Acobas F., Depetris D., Mattei M.-G., Weil D., Pujol R., Petit C.
      Genomics 40:332-341(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-1098.
      Tissue: Retina.
    6. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1023, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.

    Entry informationi

    Entry nameiMYO1F_HUMAN
    AccessioniPrimary (citable) accession number: O00160
    Secondary accession number(s): Q8WWN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 143 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3