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Protein

Unconventional myosin-If

Gene

MYO1F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1178ATPSequence Analysis

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. ATP binding Source: UniProtKB
  3. motor activity Source: InterPro

GO - Biological processi

  1. defense response to Gram-positive bacterium Source: Ensembl
  2. negative regulation of cell adhesion Source: Ensembl
  3. neutrophil degranulation Source: Ensembl
  4. positive regulation of cell migration Source: Ensembl
  5. regulation of actin cytoskeleton organization Source: Ensembl
  6. regulation of innate immune response Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-If
Alternative name(s):
Myosin-Ie
Gene namesi
Name:MYO1F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:7600. MYO1F.

Subcellular locationi

GO - Cellular componenti

  1. cortical actin cytoskeleton Source: Ensembl
  2. filamentous actin Source: Ensembl
  3. unconventional myosin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31402.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10981098Unconventional myosin-IfPRO_0000123452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1023 – 10231Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO00160.
PaxDbiO00160.
PRIDEiO00160.

PTM databases

PhosphoSiteiO00160.

Expressioni

Gene expression databases

BgeeiO00160.
CleanExiHS_MYO1F.
ExpressionAtlasiO00160. baseline and differential.
GenevestigatoriO00160.

Organism-specific databases

HPAiHPA055242.

Interactioni

Protein-protein interaction databases

BioGridi110638. 8 interactions.
IntActiO00160. 2 interactions.
STRINGi9606.ENSP00000344871.

Structurei

3D structure databases

ProteinModelPortaliO00160.
SMRiO00160. Positions 1044-1098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 690674Myosin motorAdd
BLAST
Domaini693 – 72230IQPROSITE-ProRule annotationAdd
BLAST
Domaini716 – 916201Myosin tailSequence AnalysisAdd
BLAST
Domaini1041 – 109858SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni579 – 58911Actin-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 myosin tail domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118956.
HOVERGENiHBG100702.
InParanoidiO00160.
KOiK10356.
OMAiRRQFAKF.
PhylomeDBiO00160.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
PR00452. SH3DOMAIN.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00160-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSKERFHWQ SHNVKQSGVD DMVLLPQITE DAIAANLRKR FMDDYIFTYI
60 70 80 90 100
GSVLISVNPF KQMPYFTDRE IDLYQGAAQY ENPPHIYALT DNMYRNMLID
110 120 130 140 150
CENQCVIISG ESGAGKTVAA KYIMGYISKV SGGGEKVQHV KDIILQSNPL
160 170 180 190 200
LEAFGNAKTV RNNNSSRFGK YFEIQFSRGG EPDGGKISNF LLEKSRVVMQ
210 220 230 240 250
NENERNFHIY YQLLEGASQE QRQNLGLMTP DYYYYLNQSD TYQVDGTDDR
260 270 280 290 300
SDFGETLSAM QVIGIPPSIQ QLVLQLVAGI LHLGNISFCE DGNYARVESV
310 320 330 340 350
DLLAFPAYLL GIDSGRLQEK LTSRKMDSRW GGRSESINVT LNVEQAAYTR
360 370 380 390 400
DALAKGLYAR LFDFLVEAIN RAMQKPQEEY SIGVLDIYGF EIFQKNGFEQ
410 420 430 440 450
FCINFVNEKL QQIFIELTLK AEQEEYVQEG IRWTPIQYFN NKVVCDLIEN
460 470 480 490 500
KLSPPGIMSV LDDVCATMHA TGGGADQTLL QKLQAAVGTH EHFNSWSAGF
510 520 530 540 550
VIHHYAGKVS YDVSGFCERN RDVLFSDLIE LMQTSEQAFL RMLFPEKLDG
560 570 580 590 600
DKKGRPSTAG SKIKKQANDL VATLMRCTPH YIRCIKPNET KRPRDWEENR
610 620 630 640 650
VKHQVEYLGL KENIRVRRAG FAYRRQFAKF LQRYAILTPE TWPRWRGDER
660 670 680 690 700
QGVQHLLRAV NMEPDQYQMG STKVFVKNPE SLFLLEEVRE RKFDGFARTI
710 720 730 740 750
QKAWRRHVAV RKYEEMREEA SNILLNKKER RRNSINRNFV GDYLGLEERP
760 770 780 790 800
ELRQFLGKRE RVDFADSVTK YDRRFKPIKR DLILTPKCVY VIGREKVKKG
810 820 830 840 850
PEKGQVCEVL KKKVDIQALR GVSLSTRQDD FFILQEDAAD SFLESVFKTE
860 870 880 890 900
FVSLLCKRFE EATRRPLPLT FSDTLQFRVK KEGWGGGGTR SVTFSRGFGD
910 920 930 940 950
LAVLKVGGRT LTVSVGDGLP KSSKPTRKGM AKGKPRRSSQ APTRAAPAPP
960 970 980 990 1000
RGMDRNGVPP SARGGPLPLE IMSGGGTHRP PRGPPSTSLG ASRRPRARPP
1010 1020 1030 1040 1050
SEHNTEFLNV PDQGMAGMQR KRSVGQRPVP GVGRPKPQPR THGPRCRALY
1060 1070 1080 1090
QYVGQDVDEL SFNVNEVIEI LMEDPSGWWK GRLHGQEGLF PGNYVEKI
Length:1,098
Mass (Da):124,844
Last modified:November 24, 2009 - v3
Checksum:i75C2B1306F74C7C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti259 – 2591A → V in BAC03995. (PubMed:14702039)Curated
Sequence conflicti534 – 5363TSE → SSD in CAA67058. (PubMed:9119401)Curated
Sequence conflicti592 – 5932RP → HA in CAC83948. (PubMed:11804589)Curated
Sequence conflicti592 – 5932RP → HA in CAA67058. (PubMed:9119401)Curated
Sequence conflicti602 – 6021K → Q in CAA67058. (PubMed:9119401)Curated
Sequence conflicti759 – 7591R → K in CAC83948. (PubMed:11804589)Curated
Sequence conflicti759 – 7591R → K in CAA67058. (PubMed:9119401)Curated
Sequence conflicti797 – 7971V → M in CAC83948. (PubMed:11804589)Curated
Sequence conflicti797 – 7971V → M in CAA67058. (PubMed:9119401)Curated
Sequence conflicti805 – 8051Q → P in CAA67058. (PubMed:9119401)Curated
Sequence conflicti809 – 8091V → I in CAA67058. (PubMed:9119401)Curated
Sequence conflicti814 – 8141V → L in CAA67058. (PubMed:9119401)Curated
Sequence conflicti922 – 9221S → N in CAA67058. (PubMed:9119401)Curated
Sequence conflicti927 – 9271R → G in CAA67058. (PubMed:9119401)Curated
Sequence conflicti930 – 9301M → L in CAA67058. (PubMed:9119401)Curated
Sequence conflicti948 – 9514APPR → GAPQ in CAA67058. (PubMed:9119401)Curated
Sequence conflicti958 – 96710VPPSARGGPL → APLCPQGGAPC in CAA67058. (PubMed:9119401)Curated
Sequence conflicti971 – 99020IMSGG…STSLG → KFIWPRGHPQASPALRPHPW D in CAA67058. (PubMed:9119401)CuratedAdd
BLAST
Sequence conflicti1031 – 10311Missing in CAA67058. (PubMed:9119401)Curated
Sequence conflicti1090 – 10989FPGNYVEKI → GSPSARSPA in BAC03995. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti960 – 9601P → L.
Corresponds to variant rs2288411 [ dbSNP | Ensembl ].
VAR_056179

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310570 mRNA. Translation: CAC83948.1.
AK092877 mRNA. Translation: BAC03995.1.
AC092298 Genomic DNA. No translation available.
AC092316 Genomic DNA. No translation available.
AC124902 Genomic DNA. No translation available.
AC130469 Genomic DNA. No translation available.
BC028071 mRNA. Translation: AAH28071.1.
X98411 mRNA. Translation: CAA67058.1.
CCDSiCCDS42494.1.
RefSeqiNP_036467.2. NM_012335.3.
UniGeneiHs.465818.

Genome annotation databases

EnsembliENST00000338257; ENSP00000344871; ENSG00000142347.
ENST00000613525; ENSP00000481682; ENSG00000142347.
GeneIDi4542.
KEGGihsa:4542.
UCSCiuc002mkg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310570 mRNA. Translation: CAC83948.1.
AK092877 mRNA. Translation: BAC03995.1.
AC092298 Genomic DNA. No translation available.
AC092316 Genomic DNA. No translation available.
AC124902 Genomic DNA. No translation available.
AC130469 Genomic DNA. No translation available.
BC028071 mRNA. Translation: AAH28071.1.
X98411 mRNA. Translation: CAA67058.1.
CCDSiCCDS42494.1.
RefSeqiNP_036467.2. NM_012335.3.
UniGeneiHs.465818.

3D structure databases

ProteinModelPortaliO00160.
SMRiO00160. Positions 1044-1098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110638. 8 interactions.
IntActiO00160. 2 interactions.
STRINGi9606.ENSP00000344871.

PTM databases

PhosphoSiteiO00160.

Proteomic databases

MaxQBiO00160.
PaxDbiO00160.
PRIDEiO00160.

Protocols and materials databases

DNASUi4542.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338257; ENSP00000344871; ENSG00000142347.
ENST00000613525; ENSP00000481682; ENSG00000142347.
GeneIDi4542.
KEGGihsa:4542.
UCSCiuc002mkg.3. human.

Organism-specific databases

CTDi4542.
GeneCardsiGC19M008585.
H-InvDBHIX0014717.
HGNCiHGNC:7600. MYO1F.
HPAiHPA055242.
MIMi601480. gene.
neXtProtiNX_O00160.
PharmGKBiPA31402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118956.
HOVERGENiHBG100702.
InParanoidiO00160.
KOiK10356.
OMAiRRQFAKF.
PhylomeDBiO00160.
TreeFamiTF312960.

Miscellaneous databases

ChiTaRSiMYO1F. human.
GeneWikiiMYO1F.
GenomeRNAii4542.
NextBioi17517.
PROiO00160.
SOURCEiSearch...

Gene expression databases

BgeeiO00160.
CleanExiHS_MYO1F.
ExpressionAtlasiO00160. baseline and differential.
GenevestigatoriO00160.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
PR00452. SH3DOMAIN.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
    Crozet F., El-Amraoui A., Blanchard S., Lenoir M., Ripoll C., Vago P., Hamel C., Fizames C., Levi-Acobas F., Depetris D., Mattei M.-G., Weil D., Pujol R., Petit C.
    Genomics 40:332-341(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-1098.
    Tissue: Retina.
  6. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1023, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.

Entry informationi

Entry nameiMYO1F_HUMAN
AccessioniPrimary (citable) accession number: O00160
Secondary accession number(s): Q8WWN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 24, 2009
Last modified: January 7, 2015
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.