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Protein

Probable G-protein coupled receptor 25

Gene

GPR25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 25
Gene namesi
Name:GPR25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4480. GPR25.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 75CytoplasmicSequence analysisAdd BLAST15
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 126ExtracellularSequence analysisAdd BLAST30
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 155CytoplasmicSequence analysis8
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 200ExtracellularSequence analysisAdd BLAST24
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 242CytoplasmicSequence analysisAdd BLAST22
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 289ExtracellularSequence analysisAdd BLAST26
Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini311 – 361CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170128.
PharmGKBiPA28868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695441 – 361Probable G-protein coupled receptor 25Add BLAST361

Proteomic databases

PaxDbiO00155.
PeptideAtlasiO00155.
PRIDEiO00155.

PTM databases

iPTMnetiO00155.
PhosphoSitePlusiO00155.

Expressioni

Gene expression databases

BgeeiENSG00000170128.
CleanExiHS_GPR25.
GenevisibleiO00155. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109107. 7 interactors.
IntActiO00155. 13 interactors.
STRINGi9606.ENSP00000301917.

Structurei

3D structure databases

ProteinModelPortaliO00155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 100Poly-Ala5
Compositional biasi202 – 209Poly-Leu8

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJV0. Eukaryota.
ENOG4111HMZ. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000112789.
HOVERGENiHBG051803.
InParanoidiO00155.
KOiK08405.
OMAiVNRFSNI.
OrthoDBiEOG091G0MQK.
PhylomeDBiO00155.
TreeFamiTF330024.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O00155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTEPWSPS PGSAPWDYSG LDGLEELELC PAGDLPYGYV YIPALYLAAF
60 70 80 90 100
AVGLLGNAFV VWLLAGRRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAAA
110 120 130 140 150
LGGRWPFGDG LCKLSSFALA GTRCAGALLL AGMSVDRYLA VVKLLEARPL
160 170 180 190 200
RTPRCALASC CGVWAVALLA GLPSLVYRGL QPLPGGQDSQ CGEEPSHAFQ
210 220 230 240 250
GLSLLLLLLT FVLPLVVTLF CYCRISRRLR RPPHVGRARR NSLRIIFAIE
260 270 280 290 300
STFVGSWLPF SALRAVFHLA RLGALPLPCP LLLALRWGLT IATCLAFVNS
310 320 330 340 350
CANPLIYLLL DRSFRARALD GACGRTGRLA RRISSASSLS RDDSSVFRCR
360
AQAANTASAS W
Length:361
Mass (Da):38,779
Last modified:May 10, 2004 - v2
Checksum:iC9C155A415B1DE9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91939 Genomic DNA. Translation: AAB50155.2.
BC126386 mRNA. Translation: AAI26387.1.
BC126388 mRNA. Translation: AAI26389.1.
CCDSiCCDS1405.1.
PIRiJC5277.
RefSeqiNP_005289.2. NM_005298.3.
UniGeneiHs.534316.

Genome annotation databases

EnsembliENST00000304244; ENSP00000301917; ENSG00000170128.
GeneIDi2848.
KEGGihsa:2848.
UCSCiuc001gvn.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGPR25_HUMAN
AccessioniPrimary (citable) accession number: O00155
Secondary accession number(s): A0AVJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: July 5, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families