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O00155

- GPR25_HUMAN

UniProt

O00155 - GPR25_HUMAN

Protein

Probable G-protein coupled receptor 25

Gene

GPR25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 25
    Gene namesi
    Name:GPR25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4480. GPR25.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28868.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Probable G-protein coupled receptor 25PRO_0000069544Add
    BLAST

    Proteomic databases

    PaxDbiO00155.
    PRIDEiO00155.

    PTM databases

    PhosphoSiteiO00155.

    Expressioni

    Gene expression databases

    BgeeiO00155.
    CleanExiHS_GPR25.
    GenevestigatoriO00155.

    Structurei

    3D structure databases

    ProteinModelPortaliO00155.
    SMRiO00155. Positions 39-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 12630ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 1558CytoplasmicSequence Analysis
    Topological domaini177 – 20024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 28926ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini311 – 36151CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi96 – 1005Poly-Ala
    Compositional biasi202 – 2098Poly-Leu

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148034.
    HOGENOMiHOG000112789.
    HOVERGENiHBG051803.
    InParanoidiO00155.
    KOiK08405.
    OMAiLELCPSW.
    OrthoDBiEOG7X3QRD.
    PhylomeDBiO00155.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00155-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPTEPWSPS PGSAPWDYSG LDGLEELELC PAGDLPYGYV YIPALYLAAF    50
    AVGLLGNAFV VWLLAGRRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAAA 100
    LGGRWPFGDG LCKLSSFALA GTRCAGALLL AGMSVDRYLA VVKLLEARPL 150
    RTPRCALASC CGVWAVALLA GLPSLVYRGL QPLPGGQDSQ CGEEPSHAFQ 200
    GLSLLLLLLT FVLPLVVTLF CYCRISRRLR RPPHVGRARR NSLRIIFAIE 250
    STFVGSWLPF SALRAVFHLA RLGALPLPCP LLLALRWGLT IATCLAFVNS 300
    CANPLIYLLL DRSFRARALD GACGRTGRLA RRISSASSLS RDDSSVFRCR 350
    AQAANTASAS W 361
    Length:361
    Mass (Da):38,779
    Last modified:May 10, 2004 - v2
    Checksum:iC9C155A415B1DE9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91939 Genomic DNA. Translation: AAB50155.2.
    BC126386 mRNA. Translation: AAI26387.1.
    BC126388 mRNA. Translation: AAI26389.1.
    CCDSiCCDS1405.1.
    PIRiJC5277.
    RefSeqiNP_005289.2. NM_005298.3.
    UniGeneiHs.534316.

    Genome annotation databases

    EnsembliENST00000304244; ENSP00000301917; ENSG00000170128.
    GeneIDi2848.
    KEGGihsa:2848.
    UCSCiuc001gvn.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91939 Genomic DNA. Translation: AAB50155.2 .
    BC126386 mRNA. Translation: AAI26387.1 .
    BC126388 mRNA. Translation: AAI26389.1 .
    CCDSi CCDS1405.1.
    PIRi JC5277.
    RefSeqi NP_005289.2. NM_005298.3.
    UniGenei Hs.534316.

    3D structure databases

    ProteinModelPortali O00155.
    SMRi O00155. Positions 39-315.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O00155.

    Proteomic databases

    PaxDbi O00155.
    PRIDEi O00155.

    Protocols and materials databases

    DNASUi 2848.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304244 ; ENSP00000301917 ; ENSG00000170128 .
    GeneIDi 2848.
    KEGGi hsa:2848.
    UCSCi uc001gvn.2. human.

    Organism-specific databases

    CTDi 2848.
    GeneCardsi GC01P200842.
    HGNCi HGNC:4480. GPR25.
    MIMi 602174. gene.
    neXtProti NX_O00155.
    PharmGKBi PA28868.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148034.
    HOGENOMi HOG000112789.
    HOVERGENi HBG051803.
    InParanoidi O00155.
    KOi K08405.
    OMAi LELCPSW.
    OrthoDBi EOG7X3QRD.
    PhylomeDBi O00155.
    TreeFami TF330024.

    Miscellaneous databases

    GeneWikii GPR25.
    GenomeRNAii 2848.
    NextBioi 11235.
    PROi O00155.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00155.
    CleanExi HS_GPR25.
    Genevestigatori O00155.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1."
      Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q., George S.R., O'Dowd B.F.
      Biochem. Biophys. Res. Commun. 230:69-72(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q., George S.R., O'Dowd B.F.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 101-104; 116; 124 AND 157.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGPR25_HUMAN
    AccessioniPrimary (citable) accession number: O00155
    Secondary accession number(s): A0AVJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3