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Protein

Probable G-protein coupled receptor 25

Gene

GPR25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 25
Gene namesi
Name:GPR25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4480. GPR25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 7515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 12630ExtracellularSequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini148 – 1558CytoplasmicSequence Analysis
Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 20024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 24222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini264 – 28926ExtracellularSequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini311 – 36151CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Probable G-protein coupled receptor 25PRO_0000069544Add
BLAST

Proteomic databases

PaxDbiO00155.
PRIDEiO00155.

PTM databases

PhosphoSiteiO00155.

Expressioni

Gene expression databases

BgeeiO00155.
CleanExiHS_GPR25.
GenevestigatoriO00155.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-10178951,EBI-749265
CREB3L1Q96BA83EBI-10178951,EBI-6942903
GGT7Q9UJ143EBI-10178951,EBI-1058791
NAALADL2Q58DX53EBI-10178951,EBI-10178964
PNMA1Q8ND903EBI-10178951,EBI-302345
VAPBQ53XM73EBI-10178951,EBI-10178947

Protein-protein interaction databases

BioGridi109107. 7 interactions.
IntActiO00155. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliO00155.
SMRiO00155. Positions 39-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 1005Poly-Ala
Compositional biasi202 – 2098Poly-Leu

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148034.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000112789.
HOVERGENiHBG051803.
InParanoidiO00155.
KOiK08405.
OMAiDDSSVFW.
OrthoDBiEOG7X3QRD.
PhylomeDBiO00155.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTEPWSPS PGSAPWDYSG LDGLEELELC PAGDLPYGYV YIPALYLAAF
60 70 80 90 100
AVGLLGNAFV VWLLAGRRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAAA
110 120 130 140 150
LGGRWPFGDG LCKLSSFALA GTRCAGALLL AGMSVDRYLA VVKLLEARPL
160 170 180 190 200
RTPRCALASC CGVWAVALLA GLPSLVYRGL QPLPGGQDSQ CGEEPSHAFQ
210 220 230 240 250
GLSLLLLLLT FVLPLVVTLF CYCRISRRLR RPPHVGRARR NSLRIIFAIE
260 270 280 290 300
STFVGSWLPF SALRAVFHLA RLGALPLPCP LLLALRWGLT IATCLAFVNS
310 320 330 340 350
CANPLIYLLL DRSFRARALD GACGRTGRLA RRISSASSLS RDDSSVFRCR
360
AQAANTASAS W
Length:361
Mass (Da):38,779
Last modified:May 10, 2004 - v2
Checksum:iC9C155A415B1DE9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91939 Genomic DNA. Translation: AAB50155.2.
BC126386 mRNA. Translation: AAI26387.1.
BC126388 mRNA. Translation: AAI26389.1.
CCDSiCCDS1405.1.
PIRiJC5277.
RefSeqiNP_005289.2. NM_005298.3.
UniGeneiHs.534316.

Genome annotation databases

EnsembliENST00000304244; ENSP00000301917; ENSG00000170128.
GeneIDi2848.
KEGGihsa:2848.
UCSCiuc001gvn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91939 Genomic DNA. Translation: AAB50155.2.
BC126386 mRNA. Translation: AAI26387.1.
BC126388 mRNA. Translation: AAI26389.1.
CCDSiCCDS1405.1.
PIRiJC5277.
RefSeqiNP_005289.2. NM_005298.3.
UniGeneiHs.534316.

3D structure databases

ProteinModelPortaliO00155.
SMRiO00155. Positions 39-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109107. 7 interactions.
IntActiO00155. 7 interactions.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO00155.

Proteomic databases

PaxDbiO00155.
PRIDEiO00155.

Protocols and materials databases

DNASUi2848.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304244; ENSP00000301917; ENSG00000170128.
GeneIDi2848.
KEGGihsa:2848.
UCSCiuc001gvn.2. human.

Organism-specific databases

CTDi2848.
GeneCardsiGC01P200842.
HGNCiHGNC:4480. GPR25.
MIMi602174. gene.
neXtProtiNX_O00155.
PharmGKBiPA28868.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148034.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000112789.
HOVERGENiHBG051803.
InParanoidiO00155.
KOiK08405.
OMAiDDSSVFW.
OrthoDBiEOG7X3QRD.
PhylomeDBiO00155.
TreeFamiTF330024.

Miscellaneous databases

GeneWikiiGPR25.
GenomeRNAii2848.
NextBioi11235.
PROiO00155.
SOURCEiSearch...

Gene expression databases

BgeeiO00155.
CleanExiHS_GPR25.
GenevestigatoriO00155.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1."
    Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q., George S.R., O'Dowd B.F.
    Biochem. Biophys. Res. Commun. 230:69-72(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q., George S.R., O'Dowd B.F.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 101-104; 116; 124 AND 157.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGPR25_HUMAN
AccessioniPrimary (citable) accession number: O00155
Secondary accession number(s): A0AVJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: April 29, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.