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O00155 (GPR25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 25
Gene names
Name:GPR25
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Probable G-protein coupled receptor 25
PRO_0000069544

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6021Helical; Name=1; Potential
Topological domain61 – 7515Cytoplasmic Potential
Transmembrane76 – 9621Helical; Name=2; Potential
Topological domain97 – 12630Extracellular Potential
Transmembrane127 – 14721Helical; Name=3; Potential
Topological domain148 – 1558Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 20024Extracellular Potential
Transmembrane201 – 22020Helical; Name=5; Potential
Topological domain221 – 24222Cytoplasmic Potential
Transmembrane243 – 26321Helical; Name=6; Potential
Topological domain264 – 28926Extracellular Potential
Transmembrane290 – 31021Helical; Name=7; Potential
Topological domain311 – 36151Cytoplasmic Potential
Compositional bias96 – 1005Poly-Ala
Compositional bias202 – 2098Poly-Leu

Sequences

Sequence LengthMass (Da)Tools
O00155 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: C9C155A415B1DE9F

FASTA36138,779
        10         20         30         40         50         60 
MAPTEPWSPS PGSAPWDYSG LDGLEELELC PAGDLPYGYV YIPALYLAAF AVGLLGNAFV 

        70         80         90        100        110        120 
VWLLAGRRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAAA LGGRWPFGDG LCKLSSFALA 

       130        140        150        160        170        180 
GTRCAGALLL AGMSVDRYLA VVKLLEARPL RTPRCALASC CGVWAVALLA GLPSLVYRGL 

       190        200        210        220        230        240 
QPLPGGQDSQ CGEEPSHAFQ GLSLLLLLLT FVLPLVVTLF CYCRISRRLR RPPHVGRARR 

       250        260        270        280        290        300 
NSLRIIFAIE STFVGSWLPF SALRAVFHLA RLGALPLPCP LLLALRWGLT IATCLAFVNS 

       310        320        330        340        350        360 
CANPLIYLLL DRSFRARALD GACGRTGRLA RRISSASSLS RDDSSVFRCR AQAANTASAS 


W 

« Hide

References

« Hide 'large scale' references
[1]"Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1."
Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q., George S.R., O'Dowd B.F.
Biochem. Biophys. Res. Commun. 230:69-72(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q., George S.R., O'Dowd B.F.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 101-104; 116; 124 AND 157.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U91939 Genomic DNA. Translation: AAB50155.2.
BC126386 mRNA. Translation: AAI26387.1.
BC126388 mRNA. Translation: AAI26389.1.
CCDSCCDS1405.1.
PIRJC5277.
RefSeqNP_005289.2. NM_005298.3.
UniGeneHs.534316.

3D structure databases

ProteinModelPortalO00155.
SMRO00155. Positions 39-315.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO00155.

Proteomic databases

PaxDbO00155.
PRIDEO00155.

Protocols and materials databases

DNASU2848.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304244; ENSP00000301917; ENSG00000170128.
GeneID2848.
KEGGhsa:2848.
UCSCuc001gvn.2. human.

Organism-specific databases

CTD2848.
GeneCardsGC01P200842.
HGNCHGNC:4480. GPR25.
MIM602174. gene.
neXtProtNX_O00155.
PharmGKBPA28868.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148034.
HOGENOMHOG000112789.
HOVERGENHBG051803.
InParanoidO00155.
KOK08405.
OMALELCPSW.
OrthoDBEOG7X3QRD.
PhylomeDBO00155.
TreeFamTF330024.

Gene expression databases

BgeeO00155.
CleanExHS_GPR25.
GenevestigatorO00155.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR25.
GenomeRNAi2848.
NextBio11235.
PROO00155.
SOURCESearch...

Entry information

Entry nameGPR25_HUMAN
AccessionPrimary (citable) accession number: O00155
Secondary accession number(s): A0AVJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries