O00155 (GPR25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 25

Gene names

Name:

GPR25

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Probable G-protein coupled receptor 25		PRO_0000069544
Regions
	Topological domain	1 – 39	39	Extracellular Potential
	Transmembrane	40 – 60	21	Helical; Name=1; Potential
	Topological domain	61 – 75	15	Cytoplasmic Potential
	Transmembrane	76 – 96	21	Helical; Name=2; Potential
	Topological domain	97 – 126	30	Extracellular Potential
	Transmembrane	127 – 147	21	Helical; Name=3; Potential
	Topological domain	148 – 155	8	Cytoplasmic Potential
	Transmembrane	156 – 176	21	Helical; Name=4; Potential
	Topological domain	177 – 200	24	Extracellular Potential
	Transmembrane	201 – 220	20	Helical; Name=5; Potential
	Topological domain	221 – 242	22	Cytoplasmic Potential
	Transmembrane	243 – 263	21	Helical; Name=6; Potential
	Topological domain	264 – 289	26	Extracellular Potential
	Transmembrane	290 – 310	21	Helical; Name=7; Potential
	Topological domain	311 – 361	51	Cytoplasmic Potential
	Compositional bias	96 – 100	5	Poly-Ala
	Compositional bias	202 – 209	8	Poly-Leu

Sequences

	Sequence		Length	Mass (Da)
	O00155 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: C9C155A415B1DE9F	FASTA	361	38,779
	10 20 30 40 50 60 MAPTEPWSPS PGSAPWDYSG LDGLEELELC PAGDLPYGYV YIPALYLAAF AVGLLGNAFV 70 80 90 100 110 120 VWLLAGRRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAAA LGGRWPFGDG LCKLSSFALA 130 140 150 160 170 180 GTRCAGALLL AGMSVDRYLA VVKLLEARPL RTPRCALASC CGVWAVALLA GLPSLVYRGL 190 200 210 220 230 240 QPLPGGQDSQ CGEEPSHAFQ GLSLLLLLLT FVLPLVVTLF CYCRISRRLR RPPHVGRARR 250 260 270 280 290 300 NSLRIIFAIE STFVGSWLPF SALRAVFHLA RLGALPLPCP LLLALRWGLT IATCLAFVNS 310 320 330 340 350 360 CANPLIYLLL DRSFRARALD GACGRTGRLA RRISSASSLS RDDSSVFRCR AQAANTASAS W

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1." Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q., George S.R., O'Dowd B.F. Biochem. Biophys. Res. Commun. 230:69-72(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q., George S.R., O'Dowd B.F. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 101-104; 116; 124 AND 157.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U91939 Genomic DNA. Translation: AAB50155.2. BC126386 mRNA. Translation: AAI26387.1. BC126388 mRNA. Translation: AAI26389.1.
IPI	IPI00010416.
PIR	JC5277.
RefSeq	NP_005289.2. NM_005298.3.
UniGene	Hs.534316.
3D structure databases
ProteinModelPortal	O00155.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O00155.
Proteomic databases
PaxDb	O00155.
PRIDE	O00155.
Protocols and materials databases
DNASU	2848.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304244; ENSP00000301917; ENSG00000170128.
GeneID	2848.
KEGG	hsa:2848.
UCSC	uc001gvn.1. human.
Organism-specific databases
CTD	2848.
GeneCards	GC01P200842.
HGNC	HGNC:4480. GPR25.
MIM	602174. gene.
neXtProt	NX_O00155.
PharmGKB	PA28868.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148034.
HOGENOM	HOG000112789.
HOVERGEN	HBG051803.
InParanoid	O00155.
KO	K08405.
OMA	PGSAPWD.
OrthoDB	EOG4FJ898.
PhylomeDB	O00155.
Gene expression databases
Bgee	O00155.
CleanEx	HS_GPR25.
Genevestigator	O00155.
GermOnline	ENSG00000170128. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2848.
NextBio	11235.
SOURCE	Search...

Entry information

Entry name

GPR25_HUMAN

Accession

Primary (citable) accession number: O00155
Secondary accession number(s): A0AVJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.