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O00144

- FZD9_HUMAN

UniProt

O00144 - FZD9_HUMAN

Protein

Frizzled-9

Gene

FZD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. protein heterodimerization activity Source: BHF-UCL
    4. protein homodimerization activity Source: BHF-UCL
    5. Wnt-activated receptor activity Source: RefGenome
    6. Wnt-protein binding Source: UniProtKB

    GO - Biological processi

    1. B cell differentiation Source: RefGenome
    2. brain development Source: RefGenome
    3. canonical Wnt signaling pathway Source: RefGenome
    4. gonad development Source: RefGenome
    5. learning or memory Source: Ensembl
    6. nervous system development Source: ProtInc
    7. neuroblast proliferation Source: RefGenome
    8. vasculature development Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
    SignaLinkiO00144.

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-9
    Short name:
    Fz-9
    Short name:
    hFz9
    Alternative name(s):
    FzE6
    CD_antigen: CD349
    Gene namesi
    Name:FZD9
    Synonyms:FZD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4047. FZD9.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. cytoplasm Source: BHF-UCL
    3. filopodium membrane Source: RefGenome
    4. integral component of membrane Source: ProtInc
    5. perinuclear region of cytoplasm Source: RefGenome
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28464.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 591569Frizzled-9PRO_0000013003Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi39 ↔ 100PROSITE-ProRule annotation
    Disulfide bondi47 ↔ 93PROSITE-ProRule annotation
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi84 ↔ 122PROSITE-ProRule annotation
    Disulfide bondi111 ↔ 152PROSITE-ProRule annotation
    Disulfide bondi115 ↔ 139PROSITE-ProRule annotation
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO00144.
    PRIDEiO00144.

    PTM databases

    PhosphoSiteiO00144.

    Expressioni

    Tissue specificityi

    Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.

    Gene expression databases

    BgeeiO00144.
    CleanExiHS_FZD3.
    HS_FZD9.
    GenevestigatoriO00144.

    Interactioni

    Protein-protein interaction databases

    BioGridi113922. 1 interaction.
    MINTiMINT-1477946.
    STRINGi9606.ENSP00000345785.

    Structurei

    3D structure databases

    ProteinModelPortaliO00144.
    SMRiO00144. Positions 39-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 229207ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 26616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini288 – 31528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini337 – 35519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini377 – 40024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini422 – 44726CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini469 – 50840ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini530 – 59162CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei230 – 25021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei448 – 46821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei509 – 52921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 155122FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi532 – 5376Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    HOGENOMiHOG000233236.
    HOVERGENiHBG006977.
    InParanoidiO00144.
    KOiK02842.
    OMAiNALCMEA.
    OrthoDBiEOG7M3J01.
    PhylomeDBiO00144.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O00144-1 [UniParc]FASTAAdd to Basket

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    MAVAPLRGAL LLWQLLAAGG AALEIGRFDP ERGRGAAPCQ AVEIPMCRGI    50
    GYNLTRMPNL LGHTSQGEAA AELAEFAPLV QYGCHSHLRF FLCSLYAPMC 100
    TDQVSTPIPA CRPMCEQARL RCAPIMEQFN FGWPDSLDCA RLPTRNDPHA 150
    LCMEAPENAT AGPAEPHKGL GMLPVAPRPA RPPGDLGPGA GGSGTCENPE 200
    KFQYVEKSRS CAPRCGPGVE VFWSRRDKDF ALVWMAVWSA LCFFSTAFTV 250
    LTFLLEPHRF QYPERPIIFL SMCYNVYSLA FLIRAVAGAQ SVACDQEAGA 300
    LYVIQEGLEN TGCTLVFLLL YYFGMASSLW WVVLTLTWFL AAGKKWGHEA 350
    IEAHGSYFHM AAWGLPALKT IVILTLRKVA GDELTGLCYV ASTDAAALTG 400
    FVLVPLSGYL VLGSSFLLTG FVALFHIRKI MKTGGTNTEK LEKLMVKIGV 450
    FSILYTVPAT CVIVCYVYER LNMDFWRLRA TEQPCAAAAG PGGRRDCSLP 500
    GGSVPTVAVF MLKIFMSLVV GITSGVWVWS SKTFQTWQSL CYRKIAAGRA 550
    RAKACRAPGS YGRGTHCHYK APTVVLHMTK TDPSLENPTH L 591
    Length:591
    Mass (Da):64,466
    Last modified:July 1, 1997 - v1
    Checksum:i0D3784A78DF0B2E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82169 mRNA. Translation: AAC51174.1.
    AC005049 Genomic DNA. Translation: AAQ93359.1.
    CCDSiCCDS5548.1.
    RefSeqiNP_003499.1. NM_003508.2.
    UniGeneiHs.647029.

    Genome annotation databases

    EnsembliENST00000344575; ENSP00000345785; ENSG00000188763.
    GeneIDi8326.
    KEGGihsa:8326.
    UCSCiuc003tyb.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82169 mRNA. Translation: AAC51174.1 .
    AC005049 Genomic DNA. Translation: AAQ93359.1 .
    CCDSi CCDS5548.1.
    RefSeqi NP_003499.1. NM_003508.2.
    UniGenei Hs.647029.

    3D structure databases

    ProteinModelPortali O00144.
    SMRi O00144. Positions 39-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113922. 1 interaction.
    MINTi MINT-1477946.
    STRINGi 9606.ENSP00000345785.

    Protein family/group databases

    MEROPSi I93.001.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei O00144.

    Proteomic databases

    PaxDbi O00144.
    PRIDEi O00144.

    Protocols and materials databases

    DNASUi 8326.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344575 ; ENSP00000345785 ; ENSG00000188763 .
    GeneIDi 8326.
    KEGGi hsa:8326.
    UCSCi uc003tyb.3. human.

    Organism-specific databases

    CTDi 8326.
    GeneCardsi GC07P072848.
    HGNCi HGNC:4047. FZD9.
    MIMi 601766. gene.
    neXtProti NX_O00144.
    PharmGKBi PA28464.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257258.
    HOGENOMi HOG000233236.
    HOVERGENi HBG006977.
    InParanoidi O00144.
    KOi K02842.
    OMAi NALCMEA.
    OrthoDBi EOG7M3J01.
    PhylomeDBi O00144.
    TreeFami TF317907.

    Enzyme and pathway databases

    Reactomei REACT_18372. Class B/2 (Secretin family receptors).
    SignaLinki O00144.

    Miscellaneous databases

    GeneWikii FZD9.
    GenomeRNAii 8326.
    NextBioi 31179.
    PROi O00144.
    SOURCEi Search...

    Gene expression databases

    Bgeei O00144.
    CleanExi HS_FZD3.
    HS_FZD9.
    Genevestigatori O00144.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23."
      Wang Y.-K., Samos H.C., Peoples R., Perez-Jurado L.A., Nusse R., Francke U.
      Hum. Mol. Genet. 6:465-472(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
      Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
      Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 269-329.
      Tissue: Esophageal carcinoma.

    Entry informationi

    Entry nameiFZD9_HUMAN
    AccessioniPrimary (citable) accession number: O00144
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Has been first described as FZD3 in literature.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3