##gff-version 3
O00142	UniProtKB	Transit peptide	1	33	.	.	.	Note=Mitochondrion;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9989599;Dbxref=PMID:9989599	
O00142	UniProtKB	Chain	34	265	.	.	.	ID=PRO_0000016842;Note=Thymidine kinase 2%2C mitochondrial	
O00142	UniProtKB	Region	20	47	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O00142	UniProtKB	Active site	133	133	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O57203	
O00142	UniProtKB	Binding site	57	65	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O57203	
O00142	UniProtKB	Alternative sequence	1	97	.	.	.	ID=VSP_054606;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O00142	UniProtKB	Alternative sequence	1	41	.	.	.	ID=VSP_003028;Note=In isoform 2. MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPP->MGAFCQRPSS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9079672;Dbxref=PMID:9079672	
O00142	UniProtKB	Alternative sequence	1	1	.	.	.	ID=VSP_058694;Note=In isoform 6. M->MRPGLFKGQAPGSRRRPTAGLAVVRADSHKKEPRASGSARPAM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:20843780;Dbxref=PMID:20843780	
O00142	UniProtKB	Alternative sequence	53	77	.	.	.	ID=VSP_043503;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O00142	UniProtKB	Alternative sequence	78	95	.	.	.	ID=VSP_044459;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O00142	UniProtKB	Natural variant	53	53	.	.	.	ID=VAR_019419;Note=In MTDPS2. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12391347;Dbxref=dbSNP:rs137854432,PMID:12391347	
O00142	UniProtKB	Natural variant	64	64	.	.	.	ID=VAR_023790;Note=In MTDPS2. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15907288;Dbxref=dbSNP:rs281865487,PMID:15907288	
O00142	UniProtKB	Natural variant	108	108	.	.	.	ID=VAR_019420;Note=In MTDPS2%3B reduction of activity. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12391347,ECO:0000269|PubMed:15639197;Dbxref=dbSNP:rs137854431,PMID:12391347,PMID:15639197	
O00142	UniProtKB	Natural variant	117	117	.	.	.	ID=VAR_072789;Note=In MTDPS2%3B severe form of combined brain and muscular atrophy%3B depletion of mtDNA in skeletal muscle%3B normal residual mtDNA in blood and fibroblasts. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25446393;Dbxref=PMID:25446393	
O00142	UniProtKB	Natural variant	121	121	.	.	.	ID=VAR_019421;Note=In MTDPS2%3B reduction of activity in muscles. H->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11687801,ECO:0000269|PubMed:12391347;Dbxref=dbSNP:rs137854429,PMID:11687801,PMID:12391347	
O00142	UniProtKB	Natural variant	139	139	.	.	.	ID=VAR_072790;Note=In MTDPS2%3B severe form of combined brain and muscular atrophy%3B depletion of mtDNA in skeletal muscle%3B normal residual mtDNA in blood and fibroblasts. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25446393;Dbxref=dbSNP:rs281865494,PMID:25446393	
O00142	UniProtKB	Natural variant	183	183	.	.	.	ID=VAR_023791;Note=In MTDPS2 and PEOB3%3B reduction of activity%3B reduced affinity for ATP. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15907288,ECO:0000269|PubMed:21937588;Dbxref=dbSNP:rs137886900,PMID:15907288,PMID:21937588	
O00142	UniProtKB	Natural variant	188	188	.	.	.	ID=VAR_076984;Note=In PEOB3%3B reduction of activity%3B reduced affinity for ATP. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21937588;Dbxref=dbSNP:rs281865495,PMID:21937588	
O00142	UniProtKB	Natural variant	192	192	.	.	.	ID=VAR_023792;Note=In MTDPS2%3B reduction of activity. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15639197;Dbxref=dbSNP:rs281865496,PMID:15639197	
O00142	UniProtKB	Natural variant	212	212	.	.	.	ID=VAR_019422;Note=In MTDPS2%3B reduction of activity in muscles. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11687801;Dbxref=dbSNP:rs137854430,PMID:11687801	
O00142	UniProtKB	Sequence conflict	37	37	.	.	.	Note=R->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00142	UniProtKB	Sequence conflict	49	49	.	.	.	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00142	UniProtKB	Sequence conflict	61	61	.	.	.	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00142	UniProtKB	Sequence conflict	206	206	.	.	.	Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00142	UniProtKB	Sequence conflict	238	238	.	.	.	Note=D->DH;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00142	UniProtKB	Sequence conflict	241	241	.	.	.	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00142	UniProtKB	Sequence conflict	251	251	.	.	.	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305