##gff-version 3
O00115	UniProtKB	Signal peptide	1	18	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
O00115	UniProtKB	Chain	19	360	.	.	.	ID=PRO_0000007291;Note=Deoxyribonuclease-2-alpha	
O00115	UniProtKB	Active site	295	295	.	.	.	Ontology_term=ECO:0000305;evidence=ECO:0000305	
O00115	UniProtKB	Glycosylation	86	86	.	.	.	Note=N-linked (GlcNAc...) asparagine	
O00115	UniProtKB	Glycosylation	212	212	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12754519,ECO:0000269|PubMed:19159218;Dbxref=PMID:12754519,PMID:19159218	
O00115	UniProtKB	Glycosylation	266	266	.	.	.	Note=N-linked (GlcNAc...) asparagine	
O00115	UniProtKB	Glycosylation	290	290	.	.	.	Note=N-linked (GlcNAc...) asparagine	
O00115	UniProtKB	Disulfide bond	19	159	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
O00115	UniProtKB	Disulfide bond	267	347	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
O00115	UniProtKB	Disulfide bond	308	327	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
O00115	UniProtKB	Alternative sequence	116	170	.	.	.	ID=VSP_056921;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O00115	UniProtKB	Natural variant	39	39	.	.	.	ID=VAR_048870;Note=R->I;Dbxref=dbSNP:rs36075196	
O00115	UniProtKB	Natural variant	95	95	.	.	.	ID=VAR_087103;Note=In AIPCS%3B complete loss of DNase activity in a single radial enzyme diffusion assay%2C confirmed by deficiency in DNA degradation in the granulocytes of a homozygous patient%3B no effect on expression level. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31775019;Dbxref=dbSNP:rs201030953,PMID:31775019	
O00115	UniProtKB	Natural variant	116	116	.	.	.	ID=VAR_087104;Note=In AIPCS%3B the genetic variation producing this missense variant predominantly affects splicing and the protein resulting from this aberrant splicing may be unstable%3B reduced DNase activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29259162;Dbxref=PMID:29259162	
O00115	UniProtKB	Natural variant	121	121	.	.	.	ID=VAR_087105;Note=In AIPCS%3B reduced DNase activity. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29259162;Dbxref=PMID:29259162	
O00115	UniProtKB	Natural variant	204	204	.	.	.	ID=VAR_048871;Note=H->R;Dbxref=dbSNP:rs16978744	
O00115	UniProtKB	Natural variant	314	314	.	.	.	ID=VAR_012044;Note=R->L;Dbxref=dbSNP:rs1061192	
O00115	UniProtKB	Mutagenesis	19	19	.	.	.	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	86	86	.	.	.	Note=Reduced N-glycosylation%2C complete loss of N-glycosylation%3B when associated with Q-212%3B Q-266 and Q-290. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	151	151	.	.	.	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	159	159	.	.	.	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	212	212	.	.	.	Note=Reduced N-glycosylation%2C complete loss of N-glycosylation%3B when associated with Q-86%3B Q-266 and Q-290. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	266	266	.	.	.	Note=Reduced N-glycosylation%2C complete loss of N-glycosylation%3B when associated with Q-86%3B Q-212 and Q-290. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	267	267	.	.	.	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	290	290	.	.	.	Note=Reduced N-glycosylation%2C complete loss of N-glycosylation%3B when associated with Q-86%3B Q-212 and Q-266. N->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	295	295	.	.	.	Note=Loss of activity%2C but not of DNA-binding. H->A%2CK%2CN%2CR%2CS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12594037;Dbxref=PMID:12594037	
O00115	UniProtKB	Mutagenesis	299	299	.	.	.	Note=No effect. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	308	308	.	.	.	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	327	327	.	.	.	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Mutagenesis	347	347	.	.	.	Note=Loss of activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12558498;Dbxref=PMID:12558498	
O00115	UniProtKB	Sequence conflict	160	171	.	.	.	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305