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Protein

Putative transcription factor ovo-like protein 3

Gene

OVOL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May act as a transcription regulator.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri94 – 11623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri122 – 14423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor ovo-like protein 3
Gene namesi
Name:OVOL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14186. OVOL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Putative transcription factor ovo-like protein 3PRO_0000320622Add
BLAST

Proteomic databases

PRIDEiO00110.

PTM databases

iPTMnetiO00110.

Expressioni

Gene expression databases

ExpressionAtlasiO00110. baseline and differential.
GenevisibleiO00110. HS.

Structurei

3D structure databases

ProteinModelPortaliO00110.
SMRiO00110. Positions 96-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri94 – 11623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri122 – 14423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00740000115492.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiO00110.
OMAiDAYIPDC.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027755. TF_Ovo-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF220. PTHR10032:SF220. 1 hit.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRAFLVRSR RPQPPNWGHL PDQLRGDAYI PGGPLTVPGG KGQERRSVTI
60 70 80 90 100
WLFSSDCSSL GGPPAQQSSS VRDPWTAQPT QGNLTSAPRG PGTLGCPLCP
110 120 130 140 150
KAFPLQRMLT RHLKCHSPVR RHLCRCCGKG FHDAFDLKRH MRTHTGIRPF
160 170 180 190 200
RCSACGKAFT QRCSLEAHLA KVHGQPASYA YRERREKLHV CEDCGFTSSR
210
PDTYAQHRAL HRAA
Length:214
Mass (Da):23,826
Last modified:January 25, 2012 - v3
Checksum:iA23D553861191AF4
GO

Sequence cautioni

The sequence AAB51180.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001527 Genomic DNA. Translation: AAB51180.1. Sequence problems.
UniGeneiHs.143920.

Genome annotation databases

EnsembliENST00000585332; ENSP00000465620; ENSG00000105261.
UCSCiuc031rkj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001527 Genomic DNA. Translation: AAB51180.1. Sequence problems.
UniGeneiHs.143920.

3D structure databases

ProteinModelPortaliO00110.
SMRiO00110. Positions 96-213.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO00110.

Proteomic databases

PRIDEiO00110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585332; ENSP00000465620; ENSG00000105261.
UCSCiuc031rkj.2. human.

Organism-specific databases

GeneCardsiOVOL3.
HGNCiHGNC:14186. OVOL3.
MIMi616442. gene.
neXtProtiNX_O00110.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00740000115492.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiO00110.
OMAiDAYIPDC.

Miscellaneous databases

PROiO00110.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiO00110. baseline and differential.
GenevisibleiO00110. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027755. TF_Ovo-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF220. PTHR10032:SF220. 1 hit.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOVOL3_HUMAN
AccessioniPrimary (citable) accession number: O00110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 25, 2012
Last modified: June 8, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.