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O00103

- UBC11_SCHPO

UniProt

O00103 - UBC11_SCHPO

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Protein

Ubiquitin-conjugating enzyme E2-20 kDa

Gene

ubc11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. ubiquitin protein ligase activity Source: PomBase

GO - Biological processi

  1. cyclin catabolic process Source: PomBase
  2. mitotic sister chromatid segregation Source: PomBase
  3. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: PomBase
  4. regulation of mitotic metaphase/anaphase transition Source: PomBase
  5. regulation of spindle checkpoint Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2-20 kDa (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Name:ubc11
Synonyms:ubcp4
ORF Names:SPCC1259.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC1259.15c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Ubiquitin-conjugating enzyme E2-20 kDaPRO_0000082566Add
BLAST

Proteomic databases

MaxQBiO00103.

Interactioni

Protein-protein interaction databases

BioGridi275761. 7 interactions.
MINTiMINT-4666438.
STRINGi4896.SPCC1259.15c-1.

Structurei

3D structure databases

ProteinModelPortaliO00103.
SMRiO00103. Positions 27-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000233454.
InParanoidiO00103.
KOiK06688.
OMAiSHKITIM.
OrthoDBiEOG7SBP18.
PhylomeDBiO00103.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00103 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSDMQNQNP HTNSKNSSSA GMAVDGHSVT KRLRSELMSL MMSNTPGISA
60 70 80 90 100
FPDSDSNLLH WAGTITGPSD TYYEGLKFKI SMSFPANYPY SPPTIIFTSP
110 120 130 140 150
MWHPNVDMSG NICLDILKDK WSAVYNVQTI LLSLQSLLGE PNNASPLNAQ
160 170
AAELWSKDPI EYKRLLMQRY KEIDEI
Length:176
Mass (Da):19,664
Last modified:July 1, 1997 - v1
Checksum:i6C80769C37AD4950
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85545 Genomic DNA. Translation: BAA20375.1.
CU329672 Genomic DNA. Translation: CAB38416.1.
PIRiT40902.
RefSeqiNP_588069.1. NM_001023061.2.

Genome annotation databases

EnsemblFungiiSPCC1259.15c.1; SPCC1259.15c.1:pep; SPCC1259.15c.
GeneIDi2539190.
KEGGispo:SPCC1259.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85545 Genomic DNA. Translation: BAA20375.1 .
CU329672 Genomic DNA. Translation: CAB38416.1 .
PIRi T40902.
RefSeqi NP_588069.1. NM_001023061.2.

3D structure databases

ProteinModelPortali O00103.
SMRi O00103. Positions 27-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275761. 7 interactions.
MINTi MINT-4666438.
STRINGi 4896.SPCC1259.15c-1.

Proteomic databases

MaxQBi O00103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC1259.15c.1 ; SPCC1259.15c.1:pep ; SPCC1259.15c .
GeneIDi 2539190.
KEGGi spo:SPCC1259.15c.

Organism-specific databases

PomBasei SPCC1259.15c.

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000233454.
InParanoidi O00103.
KOi K06688.
OMAi SHKITIM.
OrthoDBi EOG7SBP18.
PhylomeDBi O00103.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 20800361.
PROi O00103.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A ubiquitin-conjugating enzyme in fission yeast that is essential for the onset of anaphase in mitosis."
    Osaka F., Seino H., Seno T., Yamao F.
    Mol. Cell. Biol. 17:3388-3397(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiUBC11_SCHPO
AccessioniPrimary (citable) accession number: O00103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3