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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts ethanol to acetaldehyde and plays a major role in xylose fermentation.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1
Binding sitei202NADBy similarity1
Binding sitei207NADBy similarity1
Binding sitei341NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 184NADBy similarity7
Nucleotide bindingi269 – 271NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
ADH 2
Alcohol dehydrogenase I
Gene namesi
Name:ADH1
Synonyms:ADH2
ORF Names:PICST_68558
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
Proteomesi
  • UP000002258 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607271 – 348Alcohol dehydrogenase 1Add BLAST348

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi322104.XP_001382922.1.

Structurei

3D structure databases

ProteinModelPortaliO00097.
SMRiO00097.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0023. Eukaryota.
COG1064. LUCA.
InParanoidiO00097.
KOiK13953.
OMAiEYKQIPV.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

O00097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPTTQKAV VFESNGGPLL YKDIPVPTPK PNEILINVKY SGVCHTDLHA
60 70 80 90 100
WKGDWPLDTK LPLVGGHEGA GVVVGIGSNV TGWELGDYAG IKWLNGSCLN
110 120 130 140 150
CEFCQHSDEP NCAKADLSGY THDGSFQQYA TADAVQAARL PKGTDLAQAA
160 170 180 190 200
PILCAGITVY KALKTAQIQP GNWVCISGAG GGLGSLAIQY AKAMGFRVIA
210 220 230 240 250
IDGGEEKGEF VKSLGAEAYV DFTVSKDIVK DIQTATDGGP HAAINVSVSE
260 270 280 290 300
KAIAQSCQYV RSTGTVVLVG LPAGAKVVAP VFDAVVKSIS IRGSYVGNRA
310 320 330 340
DSAEAIDFFT RGLIKCPIKV VGLSELPKVY ELMEAGKVIG RYVVDTSK
Length:348
Mass (Da):36,520
Last modified:July 1, 1997 - v1
Checksum:i49C06B545D5350F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008245 Genomic DNA. Translation: AAC49991.1.
Y13397 Genomic DNA. Translation: CAA73827.1.
CP000496 Genomic DNA. Translation: ABN64893.1.
RefSeqiXP_001382922.1. XM_001382885.1.

Genome annotation databases

EnsemblFungiiABN64893; ABN64893; PICST_68558.
GeneIDi4836752.
KEGGipic:PICST_68558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008245 Genomic DNA. Translation: AAC49991.1.
Y13397 Genomic DNA. Translation: CAA73827.1.
CP000496 Genomic DNA. Translation: ABN64893.1.
RefSeqiXP_001382922.1. XM_001382885.1.

3D structure databases

ProteinModelPortaliO00097.
SMRiO00097.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322104.XP_001382922.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiABN64893; ABN64893; PICST_68558.
GeneIDi4836752.
KEGGipic:PICST_68558.

Phylogenomic databases

eggNOGiKOG0023. Eukaryota.
COG1064. LUCA.
InParanoidiO00097.
KOiK13953.
OMAiEYKQIPV.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_PICST
AccessioniPrimary (citable) accession number: O00097
Secondary accession number(s): A3LNN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: March 15, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.