Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O00091

- G6PD_SCHPO

UniProt

O00091 - G6PD_SCHPO

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521NADPBy similarity
    Binding sitei155 – 1551NADP; via carbonyl oxygenBy similarity
    Binding sitei155 – 1551SubstrateBy similarity
    Binding sitei223 – 2231SubstrateBy similarity
    Binding sitei242 – 2421SubstrateBy similarity
    Active sitei247 – 2471Proton acceptorBy similarity
    Binding sitei341 – 3411SubstrateBy similarity
    Binding sitei375 – 3751SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 258NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: PomBase
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. generation of precursor metabolites and energy Source: PomBase
    2. glucose 6-phosphate metabolic process Source: PomBase
    3. pentose-phosphate shunt, oxidative branch Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_212835. Pentose phosphate pathway (hexose monophosphate shunt).
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:zwf1
    ORF Names:SPAC3A12.18, SPAC9.01
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC3A12.18.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Glucose-6-phosphate 1-dehydrogenasePRO_0000068106Add
    BLAST

    Proteomic databases

    MaxQBiO00091.
    PaxDbiO00091.

    Interactioni

    Protein-protein interaction databases

    BioGridi279629. 4 interactions.
    IntActiO00091. 1 interaction.
    MINTiMINT-4666413.
    STRINGi4896.SPAC3A12.18-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO00091.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni185 – 1895Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046192.
    KOiK00036.
    OMAiYEIQEAN.
    OrthoDBiEOG7TXKRP.
    PhylomeDBiO00091.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O00091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSANLSIKE NGAMVVFGAS GDLSKKKTFP ALFSLFSEGR LPKDIRIVGY    50
    ARSKIEHEDF LDRITQNIKI DEEDSQAKEK LEEFKKRCSY YRGSYDKPED 100
    FEGLNSHLCE REGDRSTHNR IFYLALPPDV FVSVATNLKK KCVPEKGIAR 150
    LVIEKPFGVD LKSAQELQSQ LAPLFDEKEI YRIDHYLGKE MVQNLVHLRF 200
    CNPVISHLWD KNSISSVQIT FKEPIGTEGR GGYFDSSTIV RDIVQNHLVQ 250
    ILTLLTMETP TTFSADDLRD EKVKVLRRTR LGDLKDIVLG QYVKSKDGKK 300
    PGYLDDETVP KGSRCPTYSA IPCFIDTERW RGVPFLLKAG KAMDIGKVEI 350
    RVQFKAAANG LFKDAYHNEL VIRVQPDEAI YFKMNIKQPG LSEAPLLTDL 400
    DLTYSRRFKN MKLHEAYEAL FLDAFAGDQS RFARIDELEC AWSLVDPLLK 450
    YMEEEKPVPE PYEYGSDGPE CLYSFLKKFG YIYDSPDYYD YPVMSVPSDH 500
    Length:500
    Mass (Da):57,204
    Last modified:January 11, 2001 - v2
    Checksum:i6706DD0847762A22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB08746.1.
    PIRiT39186.
    RefSeqiNP_593344.2. NM_001018776.2.

    Genome annotation databases

    EnsemblFungiiSPAC3A12.18.1; SPAC3A12.18.1:pep; SPAC3A12.18.
    GeneIDi2543200.
    KEGGispo:SPAC3A12.18.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB08746.1 .
    PIRi T39186.
    RefSeqi NP_593344.2. NM_001018776.2.

    3D structure databases

    ProteinModelPortali O00091.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279629. 4 interactions.
    IntActi O00091. 1 interaction.
    MINTi MINT-4666413.
    STRINGi 4896.SPAC3A12.18-1.

    Proteomic databases

    MaxQBi O00091.
    PaxDbi O00091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC3A12.18.1 ; SPAC3A12.18.1:pep ; SPAC3A12.18 .
    GeneIDi 2543200.
    KEGGi spo:SPAC3A12.18.

    Organism-specific databases

    PomBasei SPAC3A12.18.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046192.
    KOi K00036.
    OMAi YEIQEAN.
    OrthoDBi EOG7TXKRP.
    PhylomeDBi O00091.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    Reactomei REACT_212835. Pentose phosphate pathway (hexose monophosphate shunt).

    Miscellaneous databases

    NextBioi 20804223.
    PROi O00091.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiG6PD_SCHPO
    AccessioniPrimary (citable) accession number: O00091
    Secondary accession number(s): Q9UT26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3