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O00091

- G6PD_SCHPO

UniProt

O00091 - G6PD_SCHPO

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
zwf1, SPAC3A12.18, SPAC9.01
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521NADP By similarity
Binding sitei155 – 1551NADP; via carbonyl oxygen By similarity
Binding sitei155 – 1551Substrate By similarity
Binding sitei223 – 2231Substrate By similarity
Binding sitei242 – 2421Substrate By similarity
Active sitei247 – 2471Proton acceptor By similarity
Binding sitei341 – 3411Substrate By similarity
Binding sitei375 – 3751Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: PomBase
  2. NADP binding Source: InterPro

GO - Biological processi

  1. generation of precursor metabolites and energy Source: PomBase
  2. glucose 6-phosphate metabolic process Source: PomBase
  3. pentose-phosphate shunt, oxidative branch Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_212835. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf1
ORF Names:SPAC3A12.18, SPAC9.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC3A12.18.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068106Add
BLAST

Proteomic databases

MaxQBiO00091.
PaxDbiO00091.

Interactioni

Protein-protein interaction databases

BioGridi279629. 4 interactions.
IntActiO00091. 1 interaction.
MINTiMINT-4666413.
STRINGi4896.SPAC3A12.18-1.

Structurei

3D structure databases

ProteinModelPortaliO00091.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni185 – 1895Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
KOiK00036.
OMAiYEIQEAN.
OrthoDBiEOG7TXKRP.
PhylomeDBiO00091.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00091-1 [UniParc]FASTAAdd to Basket

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MSSANLSIKE NGAMVVFGAS GDLSKKKTFP ALFSLFSEGR LPKDIRIVGY    50
ARSKIEHEDF LDRITQNIKI DEEDSQAKEK LEEFKKRCSY YRGSYDKPED 100
FEGLNSHLCE REGDRSTHNR IFYLALPPDV FVSVATNLKK KCVPEKGIAR 150
LVIEKPFGVD LKSAQELQSQ LAPLFDEKEI YRIDHYLGKE MVQNLVHLRF 200
CNPVISHLWD KNSISSVQIT FKEPIGTEGR GGYFDSSTIV RDIVQNHLVQ 250
ILTLLTMETP TTFSADDLRD EKVKVLRRTR LGDLKDIVLG QYVKSKDGKK 300
PGYLDDETVP KGSRCPTYSA IPCFIDTERW RGVPFLLKAG KAMDIGKVEI 350
RVQFKAAANG LFKDAYHNEL VIRVQPDEAI YFKMNIKQPG LSEAPLLTDL 400
DLTYSRRFKN MKLHEAYEAL FLDAFAGDQS RFARIDELEC AWSLVDPLLK 450
YMEEEKPVPE PYEYGSDGPE CLYSFLKKFG YIYDSPDYYD YPVMSVPSDH 500
Length:500
Mass (Da):57,204
Last modified:January 11, 2001 - v2
Checksum:i6706DD0847762A22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB08746.1.
PIRiT39186.
RefSeqiNP_593344.2. NM_001018776.2.

Genome annotation databases

EnsemblFungiiSPAC3A12.18.1; SPAC3A12.18.1:pep; SPAC3A12.18.
GeneIDi2543200.
KEGGispo:SPAC3A12.18.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB08746.1 .
PIRi T39186.
RefSeqi NP_593344.2. NM_001018776.2.

3D structure databases

ProteinModelPortali O00091.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279629. 4 interactions.
IntActi O00091. 1 interaction.
MINTi MINT-4666413.
STRINGi 4896.SPAC3A12.18-1.

Proteomic databases

MaxQBi O00091.
PaxDbi O00091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC3A12.18.1 ; SPAC3A12.18.1:pep ; SPAC3A12.18 .
GeneIDi 2543200.
KEGGi spo:SPAC3A12.18.

Organism-specific databases

PomBasei SPAC3A12.18.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046192.
KOi K00036.
OMAi YEIQEAN.
OrthoDBi EOG7TXKRP.
PhylomeDBi O00091.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
Reactomei REACT_212835. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

NextBioi 20804223.
PROi O00091.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiG6PD_SCHPO
AccessioniPrimary (citable) accession number: O00091
Secondary accession number(s): Q9UT26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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