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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf1), Probable glucose-6-phosphate 1-dehydrogenase C794.01c (SPCC794.01c), Probable glucose-6-phosphate 1-dehydrogenase C7.13c (SPAC3C7.13c)
  2. Probable 6-phosphogluconolactonase (SPCC16C4.10)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SPBC660.16)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52NADPBy similarity1
Binding sitei155NADP; via carbonyl oxygenBy similarity1
Binding sitei155SubstrateBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei242SubstrateBy similarity1
Active sitei247Proton acceptorBy similarity1
Binding sitei341SubstrateBy similarity1
Binding sitei375SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25NADPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-SPO-5628897 TP53 Regulates Metabolic Genes
R-SPO-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf1
ORF Names:SPAC3A12.18, SPAC9.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3A12.18
PomBaseiSPAC3A12.18 zwf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681061 – 500Glucose-6-phosphate 1-dehydrogenaseAdd BLAST500

Proteomic databases

MaxQBiO00091
PaxDbiO00091
PRIDEiO00091

PTM databases

iPTMnetiO00091

Interactioni

Protein-protein interaction databases

BioGridi279629, 1 interactor
IntActiO00091, 1 interactor
MINTiO00091
STRINGi4896.SPAC3A12.18.1

Structurei

3D structure databases

ProteinModelPortaliO00091
SMRiO00091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 189Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000046192
InParanoidiO00091
KOiK00036
OMAiVEICVYE
OrthoDBiEOG092C2MOH
PhylomeDBiO00091

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

O00091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSANLSIKE NGAMVVFGAS GDLSKKKTFP ALFSLFSEGR LPKDIRIVGY
60 70 80 90 100
ARSKIEHEDF LDRITQNIKI DEEDSQAKEK LEEFKKRCSY YRGSYDKPED
110 120 130 140 150
FEGLNSHLCE REGDRSTHNR IFYLALPPDV FVSVATNLKK KCVPEKGIAR
160 170 180 190 200
LVIEKPFGVD LKSAQELQSQ LAPLFDEKEI YRIDHYLGKE MVQNLVHLRF
210 220 230 240 250
CNPVISHLWD KNSISSVQIT FKEPIGTEGR GGYFDSSTIV RDIVQNHLVQ
260 270 280 290 300
ILTLLTMETP TTFSADDLRD EKVKVLRRTR LGDLKDIVLG QYVKSKDGKK
310 320 330 340 350
PGYLDDETVP KGSRCPTYSA IPCFIDTERW RGVPFLLKAG KAMDIGKVEI
360 370 380 390 400
RVQFKAAANG LFKDAYHNEL VIRVQPDEAI YFKMNIKQPG LSEAPLLTDL
410 420 430 440 450
DLTYSRRFKN MKLHEAYEAL FLDAFAGDQS RFARIDELEC AWSLVDPLLK
460 470 480 490 500
YMEEEKPVPE PYEYGSDGPE CLYSFLKKFG YIYDSPDYYD YPVMSVPSDH
Length:500
Mass (Da):57,204
Last modified:January 11, 2001 - v2
Checksum:i6706DD0847762A22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB08746.1
PIRiT39186
RefSeqiNP_593344.2, NM_001018776.2

Genome annotation databases

EnsemblFungiiSPAC3A12.18.1; SPAC3A12.18.1:pep; SPAC3A12.18
GeneIDi2543200
KEGGispo:SPAC3A12.18

Similar proteinsi

Entry informationi

Entry nameiG6PD_SCHPO
AccessioniPrimary (citable) accession number: O00091
Secondary accession number(s): Q9UT26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: June 20, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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