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Protein

Probable NADP-dependent mannitol dehydrogenase

Gene

PIG8

Organism
Uromyces fabae (Rust fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in hexitol or pentitol metabolism.

Catalytic activityi

D-mannitol + NADP+ = D-fructose + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei148SubstrateBy similarity1
Active sitei163Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 42NADPBy similarityAdd BLAST26
Nucleotide bindingi149 – 168NADPBy similarityAdd BLAST20

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADP-dependent mannitol dehydrogenase (EC:1.1.1.138)
Short name:
MtDH
Alternative name(s):
Mannitol 2-dehydrogenase [NADP(+)]
Planta-induced rust protein 8
Gene namesi
Name:PIG8
OrganismiUromyces fabae (Rust fungus)
Taxonomic identifieri55588 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaPucciniomycotinaPucciniomycetesPuccinialesPucciniaceaeUromyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547291 – 256Probable NADP-dependent mannitol dehydrogenaseAdd BLAST256

Expressioni

Developmental stagei

Haustoria and rust-infected leaves.

Structurei

3D structure databases

ProteinModelPortaliO00058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O00058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFTIDLKDQ CIIVTGGNRG IGLAMSQACA DAGAAVGIIY NSAKDAEDRA
60 70 80 90 100
SEISKKYGVK CKAYQCDVGQ QHKVKEVFKK INEELGPVTG LIANAGVSVV
110 120 130 140 150
KEALQYNKDD FNKIFDVNVF GVFNCAQAMA QIWTDTGFQR GSVVIISSMS
160 170 180 190 200
SQICNRPLTQ CFYNSSKAAV SNLGKCLAAE WAEKSIRVNM LSPGYVKTDQ
210 220 230 240 250
TSHMDQKLRD FQADGVPLKR FAEPEEMAGQ AILLLSPKAS YMTGGEYFVD

GGNLVW
Length:256
Mass (Da):27,842
Last modified:July 1, 1997 - v1
Checksum:i218677F0010364D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81790 mRNA. Translation: AAB39878.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81790 mRNA. Translation: AAB39878.1.

3D structure databases

ProteinModelPortaliO00058.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTDH_UROFA
AccessioniPrimary (citable) accession number: O00058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.