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Protein

Dehydrogenase RED3

Gene

RED3

Organism
Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) (Southern corn leaf blight fungus) (Bipolaris maydis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Dehydrogenase; part of the Tox1B locus, one of the 2 loci that mediate the biosynthesis of T-toxin, a family of linear polyketides 37 to 45 carbons in length, of which the major component is 41 carbons, and which leads to high virulence to maize (PubMed:8953776, PubMed:20192833). One of the PKSs (PKS1 or PKS2) could synthesize a precursor, used subsequently by the other PKS as starter unit, to add additional carbons (PubMed:16529376). Variability in the length of the final carbon backbone C35-47 could be achieved by varying the number of condensation cycles, or use of different starter or extender units or might be due to decarboxylation of the penultimate product, catalyzed by DEC1 (PubMed:12236595). Additional proteins are required for the biosynthesis of T-toxin, including oxidoreductases RED1, RED2, RED3, LAM1 and OXI1, as well as esterase TOX9 (PubMed:20192833).4 Publications

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Pathwayi: Mycotoxin biosynthesis

This protein is involved in Mycotoxin biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Mycotoxin biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase RED31 Publication (EC:1.1.1.1PROSITE-ProRule annotation)
Alternative name(s):
T-toxin biosynthesis protein RED3Curated
Gene namesi
Name:RED31 Publication
ORF Names:COCC4DRAFT_155403
OrganismiCochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) (Southern corn leaf blight fungus) (Bipolaris maydis)
Taxonomic identifieri665024 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeBipolaris
Proteomesi
  • UP000012338 Componenti: Unassembled WGS sequence

Pathology & Biotechi

Disruption phenotypei

Significantly reduces the production of T-toxin and decreases the virulence to maize (PubMed:20192833).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004376441 – 196Dehydrogenase RED3Add BLAST196

Structurei

3D structure databases

ProteinModelPortaliN4WW42.
SMRiN4WW42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG092C3QFN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

N4WW42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLVKGNCGC YWGIKGHWSR NCSPVCEIAN KNYYSRRGIA PRRTFWSVSN
60 70 80 90 100
KSLVHLDANS LMIDYENVFY YTTDITSNKA IIESSERIRQ DHGNPSVLIN
110 120 130 140 150
NAGVANGKTI LEESEDERRR VFNVDILAHF SLVREFLPDM IKHNHGHIVT
160 170 180 190
VASTASFLAR PQLVSYSCCK TALIAFHEGL SQELRMRHNA RKVRTT
Length:196
Mass (Da):22,273
Last modified:June 26, 2013 - v1
Checksum:iC6480DE6FF2297A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525909 Genomic DNA. Translation: ACP34153.1.
KB733525 Genomic DNA. Translation: ENH98580.1.
RefSeqiXP_014072490.1. XM_014217015.1.

Genome annotation databases

EnsemblFungiiENH98580; ENH98580; COCC4DRAFT_155403.
GeneIDi25839374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525909 Genomic DNA. Translation: ACP34153.1.
KB733525 Genomic DNA. Translation: ENH98580.1.
RefSeqiXP_014072490.1. XM_014217015.1.

3D structure databases

ProteinModelPortaliN4WW42.
SMRiN4WW42.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiENH98580; ENH98580; COCC4DRAFT_155403.
GeneIDi25839374.

Phylogenomic databases

OrthoDBiEOG092C3QFN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRED3_COCH4
AccessioniPrimary (citable) accession number: N4WW42
Secondary accession number(s): C3JXE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: June 26, 2013
Last modified: March 15, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.