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N0CJ65

- N0CJ65_9ACTO

UniProt

N0CJ65 - N0CJ65_9ACTO

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Protein

Probable DNA ligase

Gene
lig, SFUL_761
Organism
Streptomyces fulvissimus DSM 40593
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATP By similarityUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei215 – 2151ATP By similarityUniRule annotation
Binding sitei230 – 2301ATP By similarityUniRule annotation
Binding sitei259 – 2591ATP By similarityUniRule annotation
Binding sitei299 – 2991ATP By similarityUniRule annotation
Binding sitei377 – 3771ATP By similarityUniRule annotation
Binding sitei383 – 3831ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
ORF Names:SFUL_761Imported
OrganismiStreptomyces fulvissimus DSM 40593Imported
Taxonomic identifieri1303692 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000013304: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

N0CJ65-1 [UniParc]FASTAAdd to Basket

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MLLAELAQVS LEVAATSARS KKVALLAALF RDAGPDDVPV VIPYLAGRLP    50
QGRIGVGWRS LGDPVEPASE PTLTVTGVDA ELTALAAVSG SGSQALRRER 100
LRALFAAATA DEQHFLRALL TGEVRQGALD AVAADALARA AEAPPADVRR 150
AVMLAGSLQE VARTLLAEGP GALAAFRLTV GRPVQPMLAH TAASVTEAVD 200
KLGPCAVEEK LDGIRVQVHR DGDRVRAFTR TLDDITDRLP ELVTAVAALE 250
TGRFILDGEV IALGDDGRPR PFQETAARVG SRRDVAAAAA GVPIVPVFFD 300
ALSADGEDLL DLPYTERHTA LARLVPEHLR VRRALVPEAG DADARRAAEA 350
FLAETLERGH EGVVVKDLAA AYSAGRRGAS WLKVKPVHTL DLVVLAAEWG 400
SGRRTGKLSN LHLGARRPDG TFAMLGKTFK GLTDALLEWQ TEKLRELATG 450
EDGHVVTVRP ELVVEIAYDG LQRSTRYPAG VTLRFARVLR YREDKTAQEA 500
DTVETVLSRQ R 511
Length:511
Mass (Da):54,632
Last modified:June 26, 2013 - v1
Checksum:i0F52184B683C4F4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP005080 Genomic DNA. Translation: AGK75745.1.
RefSeqiWP_015607131.1. NC_021177.1.
YP_007929630.1. NC_021177.1.

Genome annotation databases

EnsemblBacteriaiAGK75745; AGK75745; SFUL_761.
GeneIDi15400544.
KEGGisfi:SFUL_761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP005080 Genomic DNA. Translation: AGK75745.1 .
RefSeqi WP_015607131.1. NC_021177.1.
YP_007929630.1. NC_021177.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AGK75745 ; AGK75745 ; SFUL_761 .
GeneIDi 15400544.
KEGGi sfi:SFUL_761.

Phylogenomic databases

KOi K01971.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Streptomyces fulvissimus."
    Myronovskyi M., Tokovenko B., Manderscheid N., Petzke L., Luzhetskyy A.
    Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 40593Imported.

Entry informationi

Entry nameiN0CJ65_9ACTO
AccessioniPrimary (citable) accession number: N0CJ65
Entry historyi
Integrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: September 3, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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