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N0CJ65

- N0CJ65_9ACTO

UniProt

N0CJ65 - N0CJ65_9ACTO

Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces fulvissimus DSM 40593
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei208 – 2081ATPUniRule annotation
    Active sitei210 – 2101N6-AMP-lysine intermediateUniRule annotation
    Binding sitei215 – 2151ATPUniRule annotation
    Binding sitei230 – 2301ATPUniRule annotation
    Binding sitei259 – 2591ATPUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei377 – 3771ATPUniRule annotation
    Binding sitei383 – 3831ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    ORF Names:SFUL_761Imported
    OrganismiStreptomyces fulvissimus DSM 40593Imported
    Taxonomic identifieri1303692 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000013304: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK01971.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    N0CJ65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLAELAQVS LEVAATSARS KKVALLAALF RDAGPDDVPV VIPYLAGRLP    50
    QGRIGVGWRS LGDPVEPASE PTLTVTGVDA ELTALAAVSG SGSQALRRER 100
    LRALFAAATA DEQHFLRALL TGEVRQGALD AVAADALARA AEAPPADVRR 150
    AVMLAGSLQE VARTLLAEGP GALAAFRLTV GRPVQPMLAH TAASVTEAVD 200
    KLGPCAVEEK LDGIRVQVHR DGDRVRAFTR TLDDITDRLP ELVTAVAALE 250
    TGRFILDGEV IALGDDGRPR PFQETAARVG SRRDVAAAAA GVPIVPVFFD 300
    ALSADGEDLL DLPYTERHTA LARLVPEHLR VRRALVPEAG DADARRAAEA 350
    FLAETLERGH EGVVVKDLAA AYSAGRRGAS WLKVKPVHTL DLVVLAAEWG 400
    SGRRTGKLSN LHLGARRPDG TFAMLGKTFK GLTDALLEWQ TEKLRELATG 450
    EDGHVVTVRP ELVVEIAYDG LQRSTRYPAG VTLRFARVLR YREDKTAQEA 500
    DTVETVLSRQ R 511
    Length:511
    Mass (Da):54,632
    Last modified:June 26, 2013 - v1
    Checksum:i0F52184B683C4F4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP005080 Genomic DNA. Translation: AGK75745.1.
    RefSeqiWP_015607131.1. NC_021177.1.
    YP_007929630.1. NC_021177.1.

    Genome annotation databases

    EnsemblBacteriaiAGK75745; AGK75745; SFUL_761.
    GeneIDi15400544.
    KEGGisfi:SFUL_761.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP005080 Genomic DNA. Translation: AGK75745.1 .
    RefSeqi WP_015607131.1. NC_021177.1.
    YP_007929630.1. NC_021177.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AGK75745 ; AGK75745 ; SFUL_761 .
    GeneIDi 15400544.
    KEGGi sfi:SFUL_761.

    Phylogenomic databases

    KOi K01971.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptomyces fulvissimus."
      Myronovskyi M., Tokovenko B., Manderscheid N., Petzke L., Luzhetskyy A.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 40593Imported.

    Entry informationi

    Entry nameiN0CJ65_9ACTO
    AccessioniPrimary (citable) accession number: N0CJ65
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 26, 2013
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3