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Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces fulvissimus DSM 40593
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei208ATPUniRule annotation1
Active sitei210N6-AMP-lysine intermediateUniRule annotation1
Binding sitei215ATPUniRule annotation1
Binding sitei230ATPUniRule annotation1
Binding sitei259ATPUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei377ATPUniRule annotation1
Binding sitei383ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
ORF Names:SFUL_761Imported
OrganismiStreptomyces fulvissimus DSM 40593Imported
Taxonomic identifieri1303692 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000013304 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 417DNA_LIGASE_A3InterPro annotationAdd BLAST131

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OrthoDBiPOG091H0BGA.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

N0CJ65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAELAQVS LEVAATSARS KKVALLAALF RDAGPDDVPV VIPYLAGRLP
60 70 80 90 100
QGRIGVGWRS LGDPVEPASE PTLTVTGVDA ELTALAAVSG SGSQALRRER
110 120 130 140 150
LRALFAAATA DEQHFLRALL TGEVRQGALD AVAADALARA AEAPPADVRR
160 170 180 190 200
AVMLAGSLQE VARTLLAEGP GALAAFRLTV GRPVQPMLAH TAASVTEAVD
210 220 230 240 250
KLGPCAVEEK LDGIRVQVHR DGDRVRAFTR TLDDITDRLP ELVTAVAALE
260 270 280 290 300
TGRFILDGEV IALGDDGRPR PFQETAARVG SRRDVAAAAA GVPIVPVFFD
310 320 330 340 350
ALSADGEDLL DLPYTERHTA LARLVPEHLR VRRALVPEAG DADARRAAEA
360 370 380 390 400
FLAETLERGH EGVVVKDLAA AYSAGRRGAS WLKVKPVHTL DLVVLAAEWG
410 420 430 440 450
SGRRTGKLSN LHLGARRPDG TFAMLGKTFK GLTDALLEWQ TEKLRELATG
460 470 480 490 500
EDGHVVTVRP ELVVEIAYDG LQRSTRYPAG VTLRFARVLR YREDKTAQEA
510
DTVETVLSRQ R
Length:511
Mass (Da):54,632
Last modified:June 26, 2013 - v1
Checksum:i0F52184B683C4F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP005080 Genomic DNA. Translation: AGK75745.1.
RefSeqiWP_015607131.1. NC_021177.1.

Genome annotation databases

EnsemblBacteriaiAGK75745; AGK75745; SFUL_761.
KEGGisfi:SFUL_761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP005080 Genomic DNA. Translation: AGK75745.1.
RefSeqiWP_015607131.1. NC_021177.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAGK75745; AGK75745; SFUL_761.
KEGGisfi:SFUL_761.

Phylogenomic databases

KOiK10747.
OrthoDBiPOG091H0BGA.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiN0CJ65_9ACTN
AccessioniPrimary (citable) accession number: N0CJ65
Entry historyi
Integrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: October 5, 2016
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.