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Protein

alpha-1,2-Mannosidase

Gene

Edem1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: FlyBase
  • endoplasmic reticulum unfolded protein response Source: FlyBase
  • N-glycan processing Source: GO_Central
  • ubiquitin-dependent ERAD pathway Source: FlyBase
  • ubiquitin-dependent glycoprotein ERAD pathway Source: FlyBase

Keywordsi

Molecular functionGlycosidaseUniRule annotationImported, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-901032 ER Quality Control Compartment (ERQC)

Names & Taxonomyi

Protein namesi
Recommended name:
alpha-1,2-MannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:Edem1Imported
Synonyms:DM-pIImported, Dmel\CG3810Imported, EDEM1Imported, edem1Imported, EG.86E4.2Imported, EG:86E4.2Imported
ORF Names:CG3810Imported, Dmel_CG3810Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023511 Edem1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500410186230 – 1004alpha-1,2-MannosidaseSequence analysisAdd BLAST975

Proteomic databases

PaxDbiM9PG98
PRIDEiM9PG98

Expressioni

Gene expression databases

BgeeiFBgn0023511
ExpressionAtlasiM9PG98 differential

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0304832

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2429 Eukaryota
ENOG410XS6F LUCA
OrthoDBiEOG091G04YS

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR001382 Glyco_hydro_47
IPR036026 Seven-hairpin_glycosidases
PfamiView protein in Pfam
PF01532 Glyco_hydro_47, 1 hit
PRINTSiPR00747 GLYHDRLASE47
SUPFAMiSSF48225 SSF48225, 1 hit

Sequencei

Sequence statusi: Complete.

M9PG98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQKPRNNGY PGTLICAVLL VLLSTGVSGQ KQYSKARKLE LREDVRRMFQ
60 70 80 90 100
HAYDGYLRHA SNYDELRPLT CDGHDTWGSY SLTLIDALDT LATMGNFTEF
110 120 130 140 150
RRAARLLEEK MDFDRDINVS VFETNIRIVG GLLSAHLLSK RAGVELEPGW
160 170 180 190 200
PCKGPLLRLA EDVARRLLPA FVTNTGMPYG TVNLRYGVPK GETSITCTAG
210 220 230 240 250
VGTFLIEFGT LSRLTGKTIY EDVAMKAVHA LWAYRSPIGL FGNHIDVQSG
260 270 280 290 300
RWTALDSGIG AGVDSLFEYL VKASVLLNRP ELLELFHEAR AAIDKYMRKE
310 320 330 340 350
DWYVWVGMNK GRVTLPVFQS LEAFWPGILS IIGDTEPALR TISRYIGVWK
360 370 380 390 400
KYGFLPEFYN IAAGEASPNR EVYPLRPELI ESAMYLYRAT GNEYLLEFGE
410 420 430 440 450
HMLETLEFSA KTKCGYATIR NVVTHEKENR MESFFLAETS KYLYLLFDEE
460 470 480 490 500
NFLHNDGSGG ELLSTEDDVC VVQAGAYIFN TEAHPMDMSA LHCCHAHNED
510 520 530 540 550
IYTSLDLQRF SPRAILERSK KRQVAVQEQW VPQCHPENNE FFNKEDESVQ
560 570 580 590 600
AQDSEKEQER EQSGTSTTMA VDIEVFDEFQ QPAGDLLVSN FEQIREEREL
610 620 630 640 650
NESLHRNVVA RNQLTVSDLD EFFAQRRESF ASASEALNYV KTFMGNYTMD
660 670 680 690 700
VAFIRGLQLY DTNMSSVLGT GAQKEYESRM RTLWQLYELQ QQYVANIRVI
710 720 730 740 750
QGLGLLTFPA DGDRIPSHLT EVLDSLDKSA HLEHMDLQDL ETRVSNTSSP
760 770 780 790 800
QLAHIREVIL KARNAYAIAM VNTSAMQEFA IRIYLSGTSE AGVRIHPLLE
810 820 830 840 850
DGELSEEARK RPLKLAEERA LFSYARRIVD FRKRMAETVD RLQTLMQDIP
860 870 880 890 900
PPKRKEATTD SQAADASTVY TQTKAQMAAP AQQPEPSQEE KQSTQIQKGK
910 920 930 940 950
LAENGSGLGE EESGCVWSQL VQTILRKTTV QRVKFDEAVL QENTRKALEK
960 970 980 990 1000
YARKELPHHL FACHRPEYIE GFAYRDFYPE ALKVRRRCAH DNERLNCRAK

RTER
Length:1,004
Mass (Da):114,263
Last modified:June 26, 2013 - v1
Checksum:i37332550FCA43DE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AGB94998.1
RefSeqiNP_001259152.1, NM_001272223.2
UniGeneiDm.11711

Genome annotation databases

EnsemblMetazoaiFBtr0332580; FBpp0304832; FBgn0023511
GeneIDi31154

Similar proteinsi

Entry informationi

Entry nameiM9PG98_DROME
AccessioniPrimary (citable) accession number: M9PG98
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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