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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

Ca-alpha1D

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Ca-alpha1DImported
ORF Names:CG4894Imported, Dmel_CG4894Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001991. Ca-alpha1D.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14219HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18322HelicalSequence analysisAdd
BLAST
Transmembranei195 – 21420HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27723HelicalSequence analysisAdd
BLAST
Transmembranei329 – 35022HelicalSequence analysisAdd
BLAST
Transmembranei362 – 38423HelicalSequence analysisAdd
BLAST
Transmembranei493 – 51119HelicalSequence analysisAdd
BLAST
Transmembranei523 – 54119HelicalSequence analysisAdd
BLAST
Transmembranei616 – 63621HelicalSequence analysisAdd
BLAST
Transmembranei694 – 72229HelicalSequence analysisAdd
BLAST
Transmembranei853 – 87018HelicalSequence analysisAdd
BLAST
Transmembranei890 – 91021HelicalSequence analysisAdd
BLAST
Transmembranei968 – 99730HelicalSequence analysisAdd
BLAST
Transmembranei1097 – 112024HelicalSequence analysisAdd
BLAST
Transmembranei1204 – 122219HelicalSequence analysisAdd
BLAST
Transmembranei1319 – 133719HelicalSequence analysisAdd
BLAST
Transmembranei1409 – 143325HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiM9PFZ4.

Expressioni

Gene expression databases

ExpressionAtlasiM9PFZ4. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0089047.

Structurei

3D structure databases

ProteinModelPortaliM9PFZ4.
SMRiM9PFZ4. Positions 399-427, 1517-1595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1568 – 160235Ca_chan_IQInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
OrthoDBiEOG091G0TKO.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

M9PFZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFERGASGE GGFSPNGNGG PGSGDVSRTA RYDSGEGDLG GGNNIMGIDS
60 70 80 90 100
MGIANIPETM NGTTIGPSGA GGQKGGAAAG AAGQKRQQRR GKPQPDRPQR
110 120 130 140 150
ALFCLSVKNP LRALCIRIVE WKPFEFLILL TIFANCIALA VYTPYPGSDS
160 170 180 190 200
NVTNQTLEKV EYVFLVIFTA ECVMKILAYG FVLHNGAYLR NGWNLLDFTI
210 220 230 240 250
VVIGAISTAL SQLMKDAFDV KALRAFRVLR PLRLVSGVPS LQVVLNSILK
260 270 280 290 300
AMVPLFHIAL LVLFVIIIYA IIGLELFSGK LHKACRDEIT GEYEENIRPC
310 320 330 340 350
GVGYQCPPGY KCYGGWDGPN DGITNFDNFG LAMLTVFQCV TLEGWTDVLY
360 370 380 390 400
SIQDAMGSDW QWMYFISMVI LGAFFVMNLI LGVLSGEFSK ERNKAKNRGD
410 420 430 440 450
FQKLREKQQI EEDLRGYLDW ITQAEDIEPD AVGGLISDGK GKQPNEMDST
460 470 480 490 500
ENLGEEMPEV QMTESRWRKM KKDFDRVNRR MRRACRKAVK SQAFYWLIIV
510 520 530 540 550
LVFLNTGVLA TEHYGQLDWL DNFQEYTNVF FIGLFTCEML LKMYSLGFQG
560 570 580 590 600
YFVSLFNRFD CFVVIGSITE TLLTNTGMMP PLGVSVLRCV RLLRVFKVTK
610 620 630 640 650
YWRSLSNLVA SLLNSIQSIA SLLLLLFLFI VIFALLGMQV FGGKFNFDGK
660 670 680 690 700
EEKYRMNFDC FWQALLTVFQ IMTGEDWNAV MYVGINAYGG VSSYGALACI
710 720 730 740 750
YFIILFICGN YILLNVFLAI AVDNLADADS LSEVEKEEEP HDESAQKKSH
760 770 780 790 800
SPTPTIDGMD DHLSIDIDME QQELDDEDKM DHETLSDEEV REMCEEEEEV
810 820 830 840 850
DEEGMITARP RRMSEVNTAT KILPIPPGTS FFLFSQTNRF RVFCHWLCNH
860 870 880 890 900
SNFGNIILCC IMFSSAMLAA ENPLRANDDL NKVLNKFDYF FTAVFTIELI
910 920 930 940 950
LKLISYGFVL HDGAFCRSAF NLLDLLVVCV SLISLVSSSN AISVVKILRV
960 970 980 990 1000
LRVLRPLRAI NRAKGLKHVV QCVIVAVKTI GNIVLVTCLL QFMFAVIGVQ
1010 1020 1030 1040 1050
LFKGKFFKCT DGSKMTQDEC YGTYLVYDDG DVHKPRLRER EWSNNRFHFD
1060 1070 1080 1090 1100
DVAKGMLTLF TVSTFEGWPG LLYVSIDSNK ENGGPIHNFR PIVAAYYIIY
1110 1120 1130 1140 1150
IIIIAFFMVN IFVGFVIVTF QNEGEQEYKN CDLDKNQRNC IEFALKAKPV
1160 1170 1180 1190 1200
RRYIPKHGIQ YKVWWFVTSS SFEYTIFILI MINTVTLAMK FYNQPLWYTE
1210 1220 1230 1240 1250
LLDALNMIFT AVFALEFVFK LAAFRFKNYF GDAWNVFDFI IVLGSFIDIV
1260 1270 1280 1290 1300
YSEIKSKDTS QIAECDIVEG CKSTKKSAGS NLISINFFRL FRVMRLVKLL
1310 1320 1330 1340 1350
SKGEGIRTLL WTFIKSFQAL PYVALLIVLL FFIYAVVGMQ VFGKIALDGG
1360 1370 1380 1390 1400
NAITANNNFQ TFQQAVLVLF RSATGEAWQE IMMSCSAQPD VKCDMNSDTP
1410 1420 1430 1440 1450
GEPCGSSIAY PYFISFYVLC SFLIINLFVA VIMDNFDYLT RDWSILGPHH
1460 1470 1480 1490 1500
LDEFIRLWSE YDPDAKGRIK HLDVVTLLRK ISPPLGFGKL CPHRMACKRL
1510 1520 1530 1540 1550
VSMNMPLNSD GTVLFNATLF AVVRTSLSIK TDGNIDDANS ELRATIKQIW
1560 1570 1580 1590 1600
KRTNPKLLDQ VVPPPGNDDE VTVGKFYATY LIQDYFRRFK KRKEQEGKEG
1610 1620 1630 1640 1650
HPDSNTVTLQ AGLRTLHEVS PALKRAISGN LDELDQEPEP MHRRHHTLFG
1660 1670 1680 1690 1700
SVWSSIRRHG NGTFRRSAKA TASQSNGALA IGGSASAALG VGGSSLVLGS
1710 1720 1730 1740 1750
SDPAGGDYLY DTLNRSVADG VNNITRNIMQ ARLAAAGKLQ DELQGAGSGG
1760 1770 1780 1790
ELRTFGESIS MRPLAKNGGG AATVAGTLPP EANAINYDIS DSSLKTTEC
Length:1,799
Mass (Da):201,306
Last modified:June 26, 2013 - v1
Checksum:i04AAF90A4106A6AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AGB93017.1.
RefSeqiNP_001260482.1. NM_001273553.1.
UniGeneiDm.4099.

Genome annotation databases

EnsemblMetazoaiFBtr0332022; FBpp0304338; FBgn0001991.
GeneIDi34950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AGB93017.1.
RefSeqiNP_001260482.1. NM_001273553.1.
UniGeneiDm.4099.

3D structure databases

ProteinModelPortaliM9PFZ4.
SMRiM9PFZ4. Positions 399-427, 1517-1595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0089047.

Proteomic databases

PaxDbiM9PFZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0332022; FBpp0304338; FBgn0001991.
GeneIDi34950.

Organism-specific databases

CTDi34950.
FlyBaseiFBgn0001991. Ca-alpha1D.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
OrthoDBiEOG091G0TKO.

Miscellaneous databases

ChiTaRSiCa-alpha1D. fly.
GenomeRNAii34950.

Gene expression databases

ExpressionAtlasiM9PFZ4. differential.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM9PFZ4_DROME
AccessioniPrimary (citable) accession number: M9PFZ4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: September 7, 2016
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.