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Protein

Palmitoyltransferase

Gene

Hip14

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
Name:Hip14Imported
Synonyms:3L1Imported, CG 6017Imported, dHIP14Imported, Dmel\CG6017Imported, hip14Imported, l(3)72AdImported
ORF Names:CG6017Imported, Dmel_CG6017Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0259824. Hip14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei294 – 314HelicalUniRule annotationAdd BLAST21
Transmembranei320 – 342HelicalUniRule annotationAdd BLAST23
Transmembranei349 – 369HelicalUniRule annotationAdd BLAST21
Transmembranei375 – 394HelicalUniRule annotationAdd BLAST20
Transmembranei474 – 491HelicalUniRule annotationAdd BLAST18
Transmembranei533 – 554HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiM9PFE4.
PRIDEiM9PFE4.

Expressioni

Gene expression databases

ExpressionAtlasiM9PFE4. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0303194.

Structurei

3D structure databases

ProteinModelPortaliM9PFE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 251ANK_REP_REGIONInterPro annotationAdd BLAST200
Repeati77 – 109ANKPROSITE-ProRule annotationAdd BLAST33
Repeati111 – 143ANKPROSITE-ProRule annotationAdd BLAST33
Repeati144 – 176ANKPROSITE-ProRule annotationAdd BLAST33
Repeati212 – 245ANKPROSITE-ProRule annotationAdd BLAST34

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotationSAAS annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
OMAiIMQLARI.
OrthoDBiEOG091G056H.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 5 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.

Sequencei

Sequence statusi: Complete.

M9PFE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQSACQAAT TGSCVPGTGQ QPDNERQSAL IAQQPPTAPV EPDYSGFDIV
60 70 80 90 100
KATQYGAIAR VRELVESGWD VNQPDSETVT LLHWAAINNR RDIIRYFLEK
110 120 130 140 150
GATVDAVGGE LNATPLHWAT RQGHLGAVVL LMAAGADPRI RDAEGCSCIH
160 170 180 190 200
IAAQFAHTAL VAYFIAKGVD PDLQDRGGMT ALMWAAWKVC ALDPVRLLLT
210 220 230 240 250
LGANPAMVDY THGNTALHWA ILARNATAIS TLVLKSKASL DVPNLRGETP
260 270 280 290 300
LSMLESQTGA IWIGAKVMDR VKEAALTSQQ RRSLLSKLRH DKRLRWWSMV
310 320 330 340 350
ACPFTAFYLA GIVFTVNTLY IIKFFLLGCL YSIFHTIGKA LFDEHLMALL
360 370 380 390 400
PLSVYLATKA WFYVTWLMYI DDAVSFTATV CFLISSLLLW VCFLKSWKGD
410 420 430 440 450
PGIIRPTREQ RFKTIIELSE RGGIGFEPAS FCSGCLVRRP IRSKHCSVCD
460 470 480 490 500
RCVARFDHHC PWVGNCIGLK NHSYFMGFLW MLLIMCAWML YGGSKYYVNQ
510 520 530 540 550
CNVRFDDFLG AMRAIGNCDA WVGWVMGNAL LHMSWVILLT ICQTYQVICL
560 570 580 590 600
GMTTNERMNR GRYRHFQAKG GHSPFTRGPI QNLVDFLECS CFGLVQPKRV
610 620 630 640 650
DWMNYYDYDA QTHQTIEKEP LLSVDCPDGM AGDHQYVXDK TYRDAKTLQM

PIAHV
Length:655
Mass (Da):73,379
Last modified:June 26, 2013 - v1
Checksum:i8D0386CA83C509E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AGB94603.1.
RefSeqiNP_001261910.1. NM_001274981.1.
UniGeneiDm.11460.

Genome annotation databases

EnsemblMetazoaiFBtr0330161; FBpp0303194; FBgn0259824.
GeneIDi39747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AGB94603.1.
RefSeqiNP_001261910.1. NM_001274981.1.
UniGeneiDm.11460.

3D structure databases

ProteinModelPortaliM9PFE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0303194.

Proteomic databases

PaxDbiM9PFE4.
PRIDEiM9PFE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0330161; FBpp0303194; FBgn0259824.
GeneIDi39747.

Organism-specific databases

CTDi39747.
FlyBaseiFBgn0259824. Hip14.

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
OMAiIMQLARI.
OrthoDBiEOG091G056H.

Miscellaneous databases

GenomeRNAii39747.

Gene expression databases

ExpressionAtlasiM9PFE4. differential.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 5 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiM9PFE4_DROME
AccessioniPrimary (citable) accession number: M9PFE4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: April 12, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.