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Protein
Submitted name:

PDGF-and VEGF-receptor related, isoform M

Gene

Pvr

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein tyrosine kinase activity Source: FlyBase
  • transmembrane receptor protein tyrosine kinase activity Source: FlyBase
  • vascular endothelial growth factor-activated receptor activity Source: FlyBase

GO - Biological processi

  • actin cytoskeleton organization Source: FlyBase
  • anterior Malpighian tubule development Source: FlyBase
  • antimicrobial humoral response Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell projection assembly Source: FlyBase
  • cellular response to insulin stimulus Source: FlyBase
  • hemocyte development Source: FlyBase
  • hemocyte migration Source: FlyBase
  • hemocyte proliferation Source: FlyBase
  • hemopoiesis Source: FlyBase
  • imaginal disc-derived male genitalia morphogenesis Source: FlyBase
  • innate immune response Source: FlyBase
  • intestinal stem cell homeostasis Source: FlyBase
  • larval lymph gland hemopoiesis Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • negative regulation of apoptotic process Source: FlyBase
  • positive regulation of MAPK cascade Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of hemocyte differentiation Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • TORC1 signaling Source: FlyBase
  • vascular endothelial growth factor receptor signaling pathway Source: FlyBase
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1433557 Signaling by SCF-KIT
R-DME-1433559 Regulation of KIT signaling
R-DME-216083 Integrin cell surface interactions
R-DME-3928662 EPHB-mediated forward signaling
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Submitted name:
PDGF-and VEGF-receptor related, isoform MImported (EC:2.7.10.-Imported, EC:2.7.10.1Imported)
Gene namesi
Name:PvrImported
Synonyms:8222Imported, CT24332Imported, Dmel\CG8222Imported, DmVEGFRImported, PVRImported, pvrImported, staiImported, VegfImported, VEGFRImported, VegfrImported, VEGFR-AImported, Vegfr-bImported, Vegfr-cImported, VGR1Imported, Vgr1Imported, vgr1Imported
ORF Names:CG8222Imported, Dmel_CG8222Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032006 Pvr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei851 – 872HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500410181724 – 1568Sequence analysisAdd BLAST1545

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiFBgn0032006
ExpressionAtlasiM9PCX2 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 424Ig-likeInterPro annotationAdd BLAST96
Domaini537 – 635Ig-likeInterPro annotationAdd BLAST99
Domaini646 – 742Ig-likeInterPro annotationAdd BLAST97
Domaini748 – 841Ig-likeInterPro annotationAdd BLAST94
Domaini926 – 1340Protein kinaseInterPro annotationAdd BLAST415

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
OrthoDBiEOG091G01TL

Family and domain databases

Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

M9PCX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMLPRLILL PLLLILRISW SDAVPLQQFS PDPDDSIENC GGENGAPLMT
60 70 80 90 100
PCKSAIILDA QTSTTLKCED DEPMSWWTSQ SQYVHVKSFD NTEDPARPFG
110 120 130 140 150
TSLHLIEVTA DYVAAYYCVK TSKFSQIAKE EQSDEAMIEL VNQGYASSIY
160 170 180 190 200
VYVNDPDTKL VDSHNVVTAR QYTDVVIPCK PAMPDTEVLL ETSNGEMHSS
210 220 230 240 250
KSVGRYDPQR GFTIEIRSIV DGGDYYCRPN PPFPHNEEEM TSIEVRFIAT
260 270 280 290 300
GLDIPRTQTT NMVYTYAPGV TDGDDEVLTV TNQSTGNLAL IRGGDGTLSR
310 320 330 340 350
ERARRSPARL APMNASPSPR PGQDGKPLPK PVIRSSVEHH VFTDTNFTLD
360 370 380 390 400
CEQSAYVESV YGMEWFTPSR DENRIFASQS RTDPKTRNST HQTGRSTLTV
410 420 430 440 450
LNAQPSDTGL YKCVTTDNSN QNVQRATYRI KVLKQNESYL NVGEPSGHYN
460 470 480 490 500
VQEYANRTIQ MTANFEGFPT PSFSWFKPDG TEVRQSENNF KILSTELSTM
510 520 530 540 550
LQVLNAQLQD SGTYVLRGSN SFGVVQREYN VSVMDAPALK MSDAYVQVGS
560 570 580 590 600
VARLECTVRS YPPAIVTFFF RPCSLEPQWP TCSVLNQNFS FQTRPRPGKL
610 620 630 640 650
SVERIYEVSF LPTEPGILTC IAQNIIDGKE RRTLTKAHVL LGNISENMTI
660 670 680 690 700
YGFDKDHKIA KEDNVNFTCE ALAYHFDGNL KWFINGEDLK ESDSVHIETS
710 720 730 740 750
HTKYSYKSTV HITTISDRDR GTYECRAYHN DKDAVYSSRE IDLYVHDPSA
760 770 780 790 800
PQWTNGGQEG HSKIKRKLSQ TLELECASTA VPVAIVRWFK DDKEVTESKL
810 820 830 840 850
RHIIEKESKL LITHLYPGDE GVYKCVVENR LDRIERSFTV VISDLPGISM
860 870 880 890 900
AWVWFGVILF LILIGLCVFL AVRYQKEHKR HLALKAAGLA NFEEGAVGHI
910 920 930 940 950
NPDLTLDEQA ELLPYNREFE FPRENLKLGK QLGAGAFGVV LKGEAKGIRR
960 970 980 990 1000
EEPTTTVAVK MVKATADNEV VRALVSELKI MVHLGQHLNV VNLLGAVTKN
1010 1020 1030 1040 1050
IAKRELMVIV EYCRFGNIQN FLLRNRKCFI NQINPDTDHI DPSIMTQRMS
1060 1070 1080 1090 1100
DNYELHRDTN GGGLKYANVG FPIHSYINEP HNNNTQPPTH RRNSDNDPRS
1110 1120 1130 1140 1150
GTRAGRTGSG TATYSYDRQM DTCATVMTTV PEDDQIMSNN SVQPAWRSNY
1160 1170 1180 1190 1200
KTDSTEAMTV TTVDLISWAF QVARGMDYLS SKKVLHGDLA ARNILLCEDN
1210 1220 1230 1240 1250
VVKICDFGLA RSMYRGDNYK KSENGKLPIK WLALESLSDH VFSTYSDVWS
1260 1270 1280 1290 1300
YGIVLWEMFS LAKVPYPGID PNQELFNKLN DGYRMEKPKF ANQELYEIML
1310 1320 1330 1340 1350
ECWRKNPESR PLFAELEKRF ANMLGEDVAS HYLDLNNPYM QSNIEYMKKQ
1360 1370 1380 1390 1400
STDYLALMGS PDELAPAAPR YVNGHIVPDI RIEELPDDYM EMSRDSDPDA
1410 1420 1430 1440 1450
CTAIFSPTRL EGESSDFPDF SSETTFNFPG ARQSPTLSNN LNSGSSKPLR
1460 1470 1480 1490 1500
KKNGMPTVDV ADQAPEEIPM LHRSSTGSDG SPEQGRRFNQ ALKQQYVTPT
1510 1520 1530 1540 1550
PSPRHHVETK LNGEPSENYV NMKPPRKNIP GKTTTGGGGA AAGASTEAFS
1560
NPSYQPLSTV NEKEQRRY
Length:1,568
Mass (Da):176,174
Last modified:June 26, 2013 - v1
Checksum:i5548DB9A6BE4161C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AGB92770.1
RefSeqiNP_001260234.1, NM_001273305.1
UniGeneiDm.4698

Genome annotation databases

EnsemblMetazoaiFBtr0332416; FBpp0304689; FBgn0032006
GeneIDi34127

Similar proteinsi

Entry informationi

Entry nameiM9PCX2_DROME
AccessioniPrimary (citable) accession number: M9PCX2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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