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Protein

Tachykinin-like peptide

Gene
N/A
Organism
Theloderma kwangsiense (Kwangsi warty tree frog) (Theloderma leporosa kwangsiensis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. In vitro, induces contraction of guinea pig ileum smooth muscle in a dose-dependent manner.Curated1 Publication

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-like peptide1 Publication
Alternative name(s):
Tachykinin-Thel1 Publication
OrganismiTheloderma kwangsiense (Kwangsi warty tree frog) (Theloderma leporosa kwangsiensis)
Taxonomic identifieri1258720 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRhacophoridaeRhacophorinaeTheloderma

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000042446020 – 511 PublicationAdd BLAST32
PeptideiPRO_000042446152 – 62Tachykinin-like peptide1 PublicationAdd BLAST11
PropeptideiPRO_000042446266 – 911 PublicationAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62Methionine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Expressed by the skin glands.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
PANTHERiPTHR11250. PTHR11250. 1 hit.
PfamiView protein in Pfam
PF02202. Tachykinin. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
PROSITEiView protein in PROSITE
PS00267. TACHYKININ. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

M9P2C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVAFAVI MLVSAQVLAA EIGLNDEPEW YSDQIQEDLP VFENFLQRIA
60 70 80 90
RKPSPDRFYG LMGKRNNGFG QMSRKRSAER NTIHNYERRR K
Length:91
Mass (Da):10,658
Last modified:June 26, 2013 - v1
Checksum:i1BD5DAB2C18CA5A2
GO

Mass spectrometryi

Molecular mass is 1309.6 Da from positions 52 - 62. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ867270 mRNA. Translation: AFX61593.1.

Similar proteinsi

Entry informationi

Entry nameiTKN1_THEKW
AccessioniPrimary (citable) accession number: M9P2C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: June 26, 2013
Last modified: April 12, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families