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Protein

RNA polymerase II transcription factor B subunit 2

Gene

F775_17358

Organism
Aegilops tauschii (Tausch's goatgrass) (Aegilops squarrosa)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:F775_17358Imported
OrganismiAegilops tauschii (Tausch's goatgrass) (Aegilops squarrosa)Imported
Taxonomic identifieri37682 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeAegilops

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

OMAiYLEQYAH
OrthoDBiEOG09360AVD

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 3 hits
PfamiView protein in Pfam
PF03849 Tfb2, 2 hits

Sequencei

Sequence statusi: Complete.

M8C0S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQVMVVARN FMDMVAALPA AKLDMLYDSA FICEAVLRSF PPLAKKYVIQ
60 70 80 90 100
MLYVSAPMPA AAMQEWVLDE YASKHKVAID RLLQLRVFVE VRDRRKEVSY
110 120 130 140 150
KMNNKFQANM QKYLVSGGCL PREPLPFSVT GRLPTLVELE NYALDQWEER
160 170 180 190 200
GVDPTDLISF LLELSFHTQG ACLKEVKGLQ DYIYHVKLVL HIFLFRPCCS
210 220 230 240 250
AYSLSTLTEV QRVAIMDLME LGLVKLQQGI VVVETNFRLY AYSASKLHCE
260 270 280 290 300
ILRLFSRVEY QLPNLIVGAI TKESLYGAFD NGITAEQIIS FLQQNAHPRV
310 320 330 340 350
IDKIPIVPEN VTDQIRLWEN DRNRVEMVLS HVYEDFPSKD MFEQCCDHAR
360 370 380
DNGYLLWEDA KKMRLIVNAE FHQEMREFLR RQR
Length:383
Mass (Da):44,415
Last modified:May 29, 2013 - v1
Checksum:i152F37E703998085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KD504530 Genomic DNA Translation: EMT30865.1

Genome annotation databases

EnsemblPlantsiEMT30865; EMT30865; F775_17358
GrameneiEMT30865; EMT30865; F775_17358

Similar proteinsi

Entry informationi

Entry nameiM8C0S4_AEGTA
AccessioniPrimary (citable) accession number: M8C0S4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: May 29, 2013
Last modified: May 23, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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