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Protein

Disintegrin DS-AN

Gene
N/A
Organism
Atheris nitschei (Great lakes bush viper)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits ADP-induced platelet aggregation in human platelet-rich plasma (IC50 is 8 µM).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin DS-AN
OrganismiAtheris nitschei (Great lakes bush viper)
Taxonomic identifieri110224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeAtheris

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_500112450821 – 47Add BLAST27
ChainiPRO_500112450748 – 111Disintegrin DS-ANAdd BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 76PROSITE-ProRule annotation
Disulfide bondi54InterchainPROSITE-ProRule annotation
Disulfide bondi59InterchainPROSITE-ProRule annotation
Disulfide bondi67 ↔ 73PROSITE-ProRule annotation
Disulfide bondi72 ↔ 97PROSITE-ProRule annotation
Disulfide bondi85 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer; disulfide-linked.By similarity

Structurei

3D structure databases

SMRiM5BHN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 111DisintegrinPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi89 – 91Cell attachment site3

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
PfamiView protein in Pfam
PF00200. Disintegrin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

M5BHN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQVLLVIIC LAVFPYQGSC IILESGNVND YEIVYPKKLI VLPTGAMNSP
60 70 80 90 100
HPCCDPVTCK PKKGEHCISG PCCRNCKFMN SGTICKRARG DDMNDYCTGI
110
TPDCPRNPYK D
Length:111
Mass (Da):12,246
Last modified:May 29, 2013 - v1
Checksum:i3620EE979468553A
GO

Mass spectrometryi

Molecular mass is 7071 Da from positions 48 - 111. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HF543863 mRNA. Translation: CCN27115.1.

Similar proteinsi

Entry informationi

Entry nameiDID_ATHNI
AccessioniPrimary (citable) accession number: M5BHN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: May 29, 2013
Last modified: November 22, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families