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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptococcus dysgalactiae subsp. equisimilis RE378
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei267ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotationImported
ORF Names:GGS_1791Imported
OrganismiStreptococcus dysgalactiae subsp. equisimilis RE378Imported
Taxonomic identifieri617121 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000011831 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 335tRNA-synt_1cInterPro annotationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 30"HIGH" regionUniRule annotationAdd BLAST11
Motifi264 – 268"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK09698.

Family and domain databases

CDDicd00808. GluRS_core. 1 hit.
Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022. Glu_tRNA_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR033910. GluRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

M4YYR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLQETHMS TKPIRVRYAP SPTGLLHIGN ARTALFNYLY ARHHGGTFII
60 70 80 90 100
RIEDTDRKRH VEDGERSQLE NLKWLGMDWD ESPETHEQYR QSERLDLYQK
110 120 130 140 150
YIDQLLAEGK AYKSYVTEDE LAAERERQEA AGETPRYINE FLGMTEEQKA
160 170 180 190 200
AYIAEREAAG IVPTVRLAVN EAGIYKWTDM VKGDIEFEGG NIGGDWVIQK
210 220 230 240 250
KDGYPTYNFA VVVDDHDMQI SHVIRGDDHI ANTPKQLMVY EALGWEAPAF
260 270 280 290 300
GHMTLIINSE TGKKLSKRDT NTLQFIEDYR KKGYMPEAVF NFIALLGWNP
310 320 330 340 350
GGEEEIFSRE QLIDLFDENR LSKSPAAFDQ KKMDWMSNEY LKNADFETVY
360 370 380 390 400
ALCKPFLEEA GRLTEKAEKL VELYKPQLKS ADEIIPLTDL FFSDFPELTE
410 420 430 440 450
AEKEVMAGET VPTVLQAFKE KLEAMSDEDF KPENIFPQIK AVQKETGIKG
460 470 480 490
KNLFMPIRIA VSGEMHGPEL PNTIYLLGRD KSIEHINKML
Length:490
Mass (Da):56,262
Last modified:May 29, 2013 - v1
Checksum:i8D337B0DE5764EEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011114 Genomic DNA. Translation: BAM61909.1.

Genome annotation databases

EnsemblBacteriaiBAM61909; BAM61909; GGS_1791.
KEGGisda:GGS_1791.
PATRICifig|617121.3.peg.1937.

Similar proteinsi

Entry informationi

Entry nameiM4YYR3_STREQ
AccessioniPrimary (citable) accession number: M4YYR3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: May 29, 2013
Last modified: January 31, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported