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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mannheimia haemolytica USDA-ARS-USMARC-185
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei545 – 5451UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
ORF Names:D648_15910Imported
OrganismiMannheimia haemolytica USDA-ARS-USMARC-185Imported
Taxonomic identifieri1249526 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeMannheimia
ProteomesiUP000012075: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliM4XSU3.
SMRiM4XSU3. Positions 4-879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

M4XSU3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQQYSTIQH NIHMLGEFLG ETIRDAQGNY ILELIESIRV LSRNSRAGDE
60 70 80 90 100
NAREQLLDKL ANISNDDVLP VARAFSHFLN LTNIAEQHQT VSRHHIDESL
110 120 130 140 150
GSRSLDSLFL RLKSQNIPVE KVIKTVESLM IDLVLTAHPT EVTRRSLGHK
160 170 180 190 200
HVEINKCLNL LEHDDLTEAE SYKIKRRLMQ LIALAWHTNE IRTQRPTPVD
210 220 230 240 250
EAKGGMAVIE NSLWKAVPEF CRQLNFYLEK HFGVQYPVNL APVRFSSWMG
260 270 280 290 300
GDRDGNPFVT AETTRRVLRM NRWKATELFL QDIKNLAEEL SITQCTPAFR
310 320 330 340 350
AKYGNHLEPY RVLLKVLRQK LINTEIYYAE LLEGKISTID ESDILTSDQQ
360 370 380 390 400
LWEPLFDCYE SLQACGMRII ANGALLDCLR RINCFGLGLS RLDIRQESTR
410 420 430 440 450
HEMAIAEITR YIGLGDYAHW TEDDKQAFLV RELSSRRPLI PTNWTPSPET
460 470 480 490 500
KEVLDTCKIV AEQPEGVISA YVISMAREAS DVLSVHLLLK EAGCKFTIPV
510 520 530 540 550
APLFETLGDL DHSEKVMTDL FNIGWYRGVI NNYQMIMIGY SDSAKDAGML
560 570 580 590 600
AAGWAQYRAQ EALVNLCEKY NIELTLFHGR GGTIGRGGAP AHAALLSQPP
610 620 630 640 650
RSLKNGLRVT EQGEMIRFKL GLPAVAVESL ELYASAILEA NIFPPPEPKQ
660 670 680 690 700
QWRDVLAKAS DISCQIYRDM VRGELDFVPY FRSATPEQEL SRLPLGSRPA
710 720 730 740 750
KRNPKGGVES LRAIPWIFAW MQNRLMLPAW LGAGQALQQL IDEGNETLLK
760 770 780 790 800
EMCNEWPFFS TRIGMLEMVF SKADIWLAEY YDQRLVEPKL HRLGNMLRTQ
810 820 830 840 850
LQADLKTVLA LAHDGQLMAD LPWIAESIAL RNIYTDPLNL LQVELLDRIR
860 870
KQGENADPVL EQALMITITG IAAGMRNTG
Length:879
Mass (Da):99,667
Last modified:May 29, 2013 - v1
Checksum:i737E97E1E8F7D732
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP004753 Genomic DNA. Translation: AGI35595.1.
RefSeqiYP_007669103.1. NC_020834.1.

Genome annotation databases

EnsemblBacteriaiAGI35595; AGI35595; D648_15910.
GeneIDi15008138.
KEGGimht:D648_15910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP004753 Genomic DNA. Translation: AGI35595.1.
RefSeqiYP_007669103.1. NC_020834.1.

3D structure databases

ProteinModelPortaliM4XSU3.
SMRiM4XSU3. Positions 4-879.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAGI35595; AGI35595; D648_15910.
GeneIDi15008138.
KEGGimht:D648_15910.

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete Closed Genome Sequences of Mannheimia haemolytica Serotypes A1 and A6, Isolated from Cattle."
    Harhay G.P., Koren S., Phillippy A.M., McVey D.S., Kuszak J., Clawson M.L., Harhay D.M., Heaton M.P., Chitko-McKown C.G., Smith T.P.
    Genome Announc. 1:E00188-13(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDA-ARS-USMARC-185Imported.

Entry informationi

Entry nameiM4XSU3_PASHA
AccessioniPrimary (citable) accession number: M4XSU3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: May 29, 2013
Last modified: February 4, 2015
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.