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M4MXZ9

- M4MXZ9_SINM2

UniProt

M4MXZ9 - M4MXZ9_SINM2

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Protein

Thymidine kinase

Gene

tdk

Organism
Sinorhizobium meliloti (strain Sm2011 / Rm2011 / 2011)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptorUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Metal bindingi149 – 1491ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation
Metal bindingi187 – 1871ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi89 – 924ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SM2011_c02736Imported
OrganismiSinorhizobium meliloti (strain Sm2011 / Rm2011 / 2011)Imported
Taxonomic identifieri1286640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000011827: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliM4MXZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

M4MXZ9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLYFSYAT MNAGKSTLLL QAAYNYQERG MRVVMLIAAF DDRAGQGRIA
60 70 80 90 100
SRIGLESEAI PFRAEDDLHG LIERLNGDGS GEIACVFVDE AQFLGEDQVW
110 120 130 140 150
QLARVADRLG IPVMAYGLRT DFQGKLFPGS MALLAIADEL REVRTICHCG
160 170 180 190
RKATMVVRLD GRGKVMREGA QVDVGGNEKY VSYCRRHWDD RMREG
Length:195
Mass (Da):21,788
Last modified:May 29, 2013 - v1
Checksum:iA5E114054C11A2A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004140 Genomic DNA. Translation: AGG74990.1.
RefSeqiWP_010969910.1. NC_020528.1.
YP_007575675.1. NC_020528.1.

Genome annotation databases

EnsemblBacteriaiAGG74990; AGG74990; SM2011_c02736.
GeneIDi14807278.
KEGGismel:SM2011_c02736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004140 Genomic DNA. Translation: AGG74990.1 .
RefSeqi WP_010969910.1. NC_020528.1.
YP_007575675.1. NC_020528.1.

3D structure databases

ProteinModelPortali M4MXZ9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AGG74990 ; AGG74990 ; SM2011_c02736 .
GeneIDi 14807278.
KEGGi smel:SM2011_c02736.

Phylogenomic databases

KOi K00857.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Next-generation annotation of prokaryotic genomes with EuGene-P: application to Sinorhizobium meliloti 2011."
    Sallet E., Roux B., Sauviac L., Jardinaud M.F., Carrere S., Faraut T., de Carvalho-Niebel F., Gouzy J., Gamas P., Capela D., Bruand C., Schiex T.
    DNA Res. 20:339-354(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sm2011 / Rm2011 / 2011Imported.

Entry informationi

Entry nameiM4MXZ9_SINM2
AccessioniPrimary (citable) accession number: M4MXZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: May 29, 2013
Last modified: October 29, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3