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M4MXZ9

- M4MXZ9_SINM2

UniProt

M4MXZ9 - M4MXZ9_SINM2

Protein

Thymidine kinase

Gene

tdk

Organism
Sinorhizobium meliloti (strain Sm2011 / Rm2011 / 2011)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (29 May 2013)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei90 – 901Proton acceptorUniRule annotation
    Metal bindingi147 – 1471ZincUniRule annotation
    Metal bindingi149 – 1491ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation
    Metal bindingi187 – 1871ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi89 – 924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:SM2011_c02736Imported
    OrganismiSinorhizobium meliloti (strain Sm2011 / Rm2011 / 2011)Imported
    Taxonomic identifieri1286640 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000011827: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliM4MXZ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    M4MXZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKLYFSYAT MNAGKSTLLL QAAYNYQERG MRVVMLIAAF DDRAGQGRIA    50
    SRIGLESEAI PFRAEDDLHG LIERLNGDGS GEIACVFVDE AQFLGEDQVW 100
    QLARVADRLG IPVMAYGLRT DFQGKLFPGS MALLAIADEL REVRTICHCG 150
    RKATMVVRLD GRGKVMREGA QVDVGGNEKY VSYCRRHWDD RMREG 195
    Length:195
    Mass (Da):21,788
    Last modified:May 29, 2013 - v1
    Checksum:iA5E114054C11A2A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP004140 Genomic DNA. Translation: AGG74990.1.
    RefSeqiWP_010969910.1. NC_020528.1.
    YP_007575675.1. NC_020528.1.

    Genome annotation databases

    EnsemblBacteriaiAGG74990; AGG74990; SM2011_c02736.
    GeneIDi14807278.
    KEGGismel:SM2011_c02736.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP004140 Genomic DNA. Translation: AGG74990.1 .
    RefSeqi WP_010969910.1. NC_020528.1.
    YP_007575675.1. NC_020528.1.

    3D structure databases

    ProteinModelPortali M4MXZ9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AGG74990 ; AGG74990 ; SM2011_c02736 .
    GeneIDi 14807278.
    KEGGi smel:SM2011_c02736.

    Phylogenomic databases

    KOi K00857.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Next-generation annotation of prokaryotic genomes with EuGene-P: application to Sinorhizobium meliloti 2011."
      Sallet E., Roux B., Sauviac L., Jardinaud M.F., Carrere S., Faraut T., de Carvalho-Niebel F., Gouzy J., Gamas P., Capela D., Bruand C., Schiex T.
      DNA Res. 20:339-354(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sm2011 / Rm2011 / 2011Imported.

    Entry informationi

    Entry nameiM4MXZ9_SINM2
    AccessioniPrimary (citable) accession number: M4MXZ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 29, 2013
    Last sequence update: May 29, 2013
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3