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M4MXZ9

- M4MXZ9_SINM2

UniProt

M4MXZ9 - M4MXZ9_SINM2

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Protein
Thymidine kinase
Gene
tdk, SM2011_c02736
Organism
Sinorhizobium meliloti (strain Sm2011 / Rm2011 / 2011)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptor By similarityUniRule annotation
Metal bindingi147 – 1471Zinc By similarityUniRule annotation
Metal bindingi149 – 1491Zinc By similarityUniRule annotation
Metal bindingi184 – 1841Zinc By similarityUniRule annotation
Metal bindingi187 – 1871Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi89 – 924ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SM2011_c02736Imported
OrganismiSinorhizobium meliloti (strain Sm2011 / Rm2011 / 2011)Imported
Taxonomic identifieri1286640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000011827: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliM4MXZ9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

M4MXZ9-1 [UniParc]FASTAAdd to Basket

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MSKLYFSYAT MNAGKSTLLL QAAYNYQERG MRVVMLIAAF DDRAGQGRIA    50
SRIGLESEAI PFRAEDDLHG LIERLNGDGS GEIACVFVDE AQFLGEDQVW 100
QLARVADRLG IPVMAYGLRT DFQGKLFPGS MALLAIADEL REVRTICHCG 150
RKATMVVRLD GRGKVMREGA QVDVGGNEKY VSYCRRHWDD RMREG 195
Length:195
Mass (Da):21,788
Last modified:May 29, 2013 - v1
Checksum:iA5E114054C11A2A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004140 Genomic DNA. Translation: AGG74990.1.
RefSeqiWP_010969910.1. NC_020528.1.
YP_007575675.1. NC_020528.1.

Genome annotation databases

EnsemblBacteriaiAGG74990; AGG74990; SM2011_c02736.
GeneIDi14807278.
KEGGismel:SM2011_c02736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004140 Genomic DNA. Translation: AGG74990.1 .
RefSeqi WP_010969910.1. NC_020528.1.
YP_007575675.1. NC_020528.1.

3D structure databases

ProteinModelPortali M4MXZ9.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AGG74990 ; AGG74990 ; SM2011_c02736 .
GeneIDi 14807278.
KEGGi smel:SM2011_c02736.

Phylogenomic databases

KOi K00857.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Next-generation annotation of prokaryotic genomes with EuGene-P: application to Sinorhizobium meliloti 2011."
    Sallet E., Roux B., Sauviac L., Jardinaud M.F., Carrere S., Faraut T., de Carvalho-Niebel F., Gouzy J., Gamas P., Capela D., Bruand C., Schiex T.
    DNA Res. 20:339-354(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sm2011 / Rm2011 / 2011.

Entry informationi

Entry nameiM4MXZ9_SINM2
AccessioniPrimary (citable) accession number: M4MXZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: May 29, 2013
Last modified: September 3, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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