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M4MQW4

- M4MQW4_SINM2

UniProt

M4MQW4 - M4MQW4_SINM2

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Protein

Alanine racemase

Gene

alr

Organism
Sinorhizobium meliloti (strain Sm2011 / Rm2011 / 2011)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Active sitei260 – 2601Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SM2011_c00557Imported
OrganismiSinorhizobium meliloti (strain Sm2011 / Rm2011 / 2011)Imported
Taxonomic identifieri1286640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000011827: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliM4MQW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

M4MQW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSPEFLSAS SRLTVDLTAL ADNWRAMNER SGKARAAAVL KADAYGLGVV
60 70 80 90 100
HAAPALYAAG ARDFFVASVE EGADLRPLVP DGRIYILAGM WPGNEELFFE
110 120 130 140 150
NDLVPIINSE EQLAVFMAAL SERGDHPCVL HVDTGMNRLG LSPEEALALA
160 170 180 190 200
HDPARPASFS PVLVMSHLAC ADDPGHPMNR YQLQRFREVT AAFEGVPASL
210 220 230 240 250
ANSGGVFLGA DYHFDLTRPG IAVYGGEAVN GAVNPMKAVV TAEARIVQVR
260 270 280 290 300
TVPSGGTASY GASVRFGRDS RIATVAIGYA DGYHRSVSGG GVTLRQAMPS
310 320 330 340 350
GAFGFLHGMK VPHVGRVTMD LSLFDVTDLP EAAVRAGDYI EVFGRNVVID
360 370
DVARAGGTIG YELLTSLGRR YHRTYVGGA
Length:379
Mass (Da):40,234
Last modified:May 29, 2013 - v1
Checksum:iDD8229ACDD963649
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004140 Genomic DNA. Translation: AGG73706.1.
RefSeqiWP_010969059.1. NC_020528.1.
YP_007574391.1. NC_020528.1.

Genome annotation databases

EnsemblBacteriaiAGG73706; AGG73706; SM2011_c00557.
GeneIDi14805571.
KEGGismel:SM2011_c00557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004140 Genomic DNA. Translation: AGG73706.1 .
RefSeqi WP_010969059.1. NC_020528.1.
YP_007574391.1. NC_020528.1.

3D structure databases

ProteinModelPortali M4MQW4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AGG73706 ; AGG73706 ; SM2011_c00557 .
GeneIDi 14805571.
KEGGi smel:SM2011_c00557.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Next-generation annotation of prokaryotic genomes with EuGene-P: application to Sinorhizobium meliloti 2011."
    Sallet E., Roux B., Sauviac L., Jardinaud M.F., Carrere S., Faraut T., de Carvalho-Niebel F., Gouzy J., Gamas P., Capela D., Bruand C., Schiex T.
    DNA Res. 20:339-354(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sm2011 / Rm2011 / 2011Imported.

Entry informationi

Entry nameiM4MQW4_SINM2
AccessioniPrimary (citable) accession number: M4MQW4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: May 29, 2013
Last modified: October 29, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3