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Protein
Submitted name:

Thyrotropin releasing hormone degrading enzyme

Gene

TRHDE

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Protein family/group databases

MEROPSiM01.008.

Names & Taxonomyi

Protein namesi
Submitted name:
Thyrotropin releasing hormone degrading enzymeImported
Gene namesi
Name:TRHDEImported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 107HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000017372.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini393 – 635Peptidase_M1InterPro annotationAdd BLAST243
Domaini721 – 1043ERAP1_CInterPro annotationAdd BLAST323

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili7 – 37Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1046. Eukaryota.
COG0308. LUCA.
GeneTreeiENSGT00760000119082.
InParanoidiM3Z1B0.
OMAiKYNVFNE.
OrthoDBiEOG091G01GH.

Family and domain databases

CDDicd09601. M1_APN_2. 1 hit.
InterProiView protein in InterPro
IPR024571. ERAP1-like_C_dom.
IPR034016. M1_APN-typ.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
IPR015570. TRH-DE.
PANTHERiPTHR11533. PTHR11533. 1 hit.
PTHR11533:SF205. PTHR11533:SF205. 1 hit.
PfamiView protein in Pfam
PF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
PRINTSiPR00756. ALADIPTASE.

Sequencei

Sequence statusi: Complete.

M3Z1B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDGERGEQ EEEKKKKKKK KKRKKKKEEE EEGAEKSSSP FAASMGENDA
60 70 80 90 100
ALRAGGRGLS DPWTDSVGVR PRTTERHITV HKRLVLAFAV SIVALLAVTM
110 120 130 140 150
LAVLLSLRFD ECGASAAPGA DGGLAGFPAR GGNGSLPGSA RRNHQAGGDS
160 170 180 190 200
SQPEVGGEAT PGTPSAQPPS EEEREQWQPW TQLRLSGHLK PLHYNLMLTA
210 220 230 240 250
FMENFTFSGE VNVEISCRNA TRYVVLHASR VAVEKVQVAE DRVAGAVPVA
260 270 280 290 300
GFFLYPQTQV LVVVLNRTLD AQRNYNLKII YNALIENELL GFFRSSYVLH
310 320 330 340 350
GERRFLGVTQ FSPTHARKAF PCFDEPIYKA TFKISIKHQA TYLSLSNMPV
360 370 380 390 400
ETSVFEEDGW VTDHFSQTPL MSTYYLAWAI CNFTYRETTT KSGVAVRLYA
410 420 430 440 450
RPDAIRRGSG DYALHITKRL IEFYEDYFKV PYSLPKLDLL AVPKHPYAAM
460 470 480 490 500
ENWGLSIFVE QRILLDPSVS SISYLLDVTM VIVHEICHQW FGDLVTPVWW
510 520 530 540 550
EDVWLKEGFA HYFEFVGTDY LYPGWNMEKQ RFLTDVLHEV MLLDGLASSH
560 570 580 590 600
PVSQEVLRAT DIDRVFDWIA YKKGAALIRM LANFMGHSVF QRGLQDYLTI
610 620 630 640 650
HKYGNAARND LWNTLSEALK RNGKFVNIQE VMDQWTLQMG YPVITILGNS
660 670 680 690 700
TAENRIIITQ QHFIYDISAK TKALELQNNS YLWQIPLTIV VGNRSHVSSE
710 720 730 740 750
AIIWVSNKSE HHRITLDKGS WLLGNINQTG YFRVNYDLRN WRLLIDQLIR
760 770 780 790 800
NHEVLSVSNR AGLIDDAFSL ARAGYLPQHI PLEIIRYLSE EKDFLPWHAA
810 820 830 840 850
SRALYPLDKL LDRMEKYNVF NEYILKQVAT TYIKLGWPKN NFNGSLVQAS
860 870 880 890 900
YQHEELRREV IMLACSFGNK HCHQQASTLI SDWISSNRNR IPLNVRDIVY
910 920 930 940 950
CTGVSLLDED VWEFIWMKFH STTAVSEKKI LLEALTCSDD RNLLNRLLNL
960 970 980 990 1000
SLNSEVVLDQ DAIDVIIHVA RNPHGRDLAW KFFRDKWKIL NTRYGEALFM
1010 1020 1030 1040 1050
NSKLISGVTE FLNTEGELKE LKNFMKNYDG VAAASFLRAV ETVEANVRWK
1060
MLYQDELFQW LGKALRH
Length:1,067
Mass (Da):121,804
Last modified:May 1, 2013 - v1
Checksum:i4B58E44C9B311D86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01031413 Genomic DNA. No translation available.
AEYP01031414 Genomic DNA. No translation available.
AEYP01031415 Genomic DNA. No translation available.
AEYP01031416 Genomic DNA. No translation available.
AEYP01031417 Genomic DNA. No translation available.
AEYP01031418 Genomic DNA. No translation available.
AEYP01031419 Genomic DNA. No translation available.
AEYP01031420 Genomic DNA. No translation available.
AEYP01031421 Genomic DNA. No translation available.
AEYP01031422 Genomic DNA. No translation available.
RefSeqiXP_004752474.1. XM_004752417.2.

Genome annotation databases

EnsembliENSMPUT00000017628; ENSMPUP00000017372; ENSMPUG00000017482.
GeneIDi101678354.

Similar proteinsi

Entry informationi

Entry nameiM3Z1B0_MUSPF
AccessioniPrimary (citable) accession number: M3Z1B0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: August 30, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported