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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDHA

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:SDHAImported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000010251

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 344FAD_binding_2InterPro annotationAdd BLAST343
Domaini399 – 551Succ_DH_flav_CInterPro annotationAdd BLAST153

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
GeneTreeiENSGT00910000144277
InParanoidiM3YFZ4
OMAiGDSPWEH
OrthoDBiEOG091G041Z

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit

Sequencei

Sequence statusi: Complete.

M3YFZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDNWRWHF YDTVKGSDWL GDQDAIHYMT EQAPASVVEL ENYGMPFSRT
60 70 80 90 100
EDGRIYQRAF GGQSLKFGKG GQAHRCCCVA DRTGHSLLHT LYGRSLRYDT
110 120 130 140 150
SYFVEYFALD LLMENGECRG VIALCIEDGS IHRIRAKNTV VATGGYGRTY
160 170 180 190 200
FSCTSAHTST GDGTAMVTRA GLPCQDLEFV QFHPTGIYGA GCLITEGCRG
210 220 230 240 250
EGGILINSQG ERFMERYAPV AKDLASRDVV SRSMTLEIRE GRGCGPEKDH
260 270 280 290 300
VYLQLHHLPP EQLAIRLPGI SETAMIFAGV DVTKEPIPVL PTVHYNMGGI
310 320 330 340 350
PTNYKGQVLR HVNGQDQIVP GLYACGEAAC ASVHGANRLG ANSLLDLVVF
360 370 380 390 400
GRACALSIAE SCRPGDKVPP IKPNAGEESV MNLDKLRFAD GSIRTSELRL
410 420 430 440 450
SMQKSMQNHA AVFRVGSVLQ EGCEKVSQLY GDLNHLKTFD RGMVWNTDLV
460 470 480 490 500
ETLELQNLML CALQTIYGAE ARKESRGAHA REDYKERIDE YDYSKPIQGQ
510 520 530 540 550
QKKPFEAHWR KHTLSYVDVK TGKVSLEYRP VIDRTLNEAD CATVPPAIRS

Y
Length:551
Mass (Da):61,166
Last modified:May 1, 2013 - v1
Checksum:iE687D36144F589D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01069907 Genomic DNA No translation available.
AEYP01069908 Genomic DNA No translation available.
RefSeqiXP_004768496.2, XM_004768439.2

Genome annotation databases

EnsembliENSMPUT00000010414; ENSMPUP00000010251; ENSMPUG00000010324
GeneIDi101678731

Similar proteinsi

Entry informationi

Entry nameiM3YFZ4_MUSPF
AccessioniPrimary (citable) accession number: M3YFZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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