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Protein

Annexin

Gene

ANXA1

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:ANXA1Imported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000008827.

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiM3YBX0.
OMAiGTRHKTL.
OrthoDBiEOG091G0H6H.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR037104. Annexin_sf.
IPR002388. ANX1.
PANTHERiPTHR10502:SF17. PTHR10502:SF17. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 3 hits.

Sequencei

Sequence statusi: Complete.

M3YBX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVSEFLKQ AWFIENEEQE YIKTVKGSKG GPGSAVSPYP SFNPSSDVAA
60 70 80 90 100
LHNAITVKGV DEATIIDILT KRNNAQRQQI KAAYLQEKGK PLDEALKKAL
110 120 130 140 150
SGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLDEI LASRTNKEIR
160 170 180 190 200
EINRVYREEL KRDLAKDITS DTSGDYRNAL LSLAKGDRSE DLGWNDDLAD
210 220 230 240 250
TDARALYEAG ERRKGTDVNV FVTILTTRAY PHLRQVFQKY RKYSKHDMNK
260 270 280 290 300
VLDLEMKGDI EKCLTAIVKC ATSKPMFFAE KLHQAMKGSG TRHKTLIRIM
310 320 330 340
VSRSEIDMND IKACYQKLYG ISLCQAILDE TKGDYEKILV ALCGD
Length:345
Mass (Da):38,691
Last modified:May 1, 2013 - v1
Checksum:i8BD1E481E09009A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01072394 Genomic DNA. No translation available.
RefSeqiXP_004769258.1. XM_004769201.2.

Genome annotation databases

EnsembliENSMPUT00000008971; ENSMPUP00000008827; ENSMPUG00000008897.
GeneIDi101679130.

Similar proteinsi

Entry informationi

Entry nameiM3YBX0_MUSPF
AccessioniPrimary (citable) accession number: M3YBX0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: October 25, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported