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Protein

Erythropoietin receptor

Gene

EPOR

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for erythropoietin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119Required for ligand bindingUniRule annotation1
Sitei429Required for STAT5/PTPN11/SOCS3 bindingUniRule annotation1
Sitei459Required for STAT1/STAT3 activationUniRule annotation1
Sitei488Required for CrkL bindingUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin receptorUniRule annotation
Short name:
EPO-RUniRule annotation
Gene namesi
Name:EPORImported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei254 – 275HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500404427426 – 511Erythropoietin receptorSequence analysisAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 64UniRule annotation
Disulfide bondi93 ↔ 109UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Subunit structurei

Forms homodimers on EPO stimulation.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei371Interaction with APS and STAT5, and activationUniRule annotation1
Sitei457Interaction with PTPN6UniRule annotation1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000005395

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 250Fibronectin type-IIIInterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFGH Eukaryota
ENOG4111PGS LUCA
GeneTreeiENSGT00890000139540
InParanoidiM3Y244
OMAiVGSEHAQ
OrthoDBiEOG091G0AK8

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR009167 Erythropoietin_rcpt
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
PANTHERiPTHR23037:SF28 PTHR23037:SF28, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PIRSFiPIRSF001959 EPO_receptor, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit

Sequencei

Sequence statusi: Complete.

M3Y244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHFRAHLWP GVCSLCLLLA GAAWASPPKS LDPKFESKAA AALLAAREPE
60 70 80 90 100
ELLCFTERLE DLVCFWEEAP SAGVGPNNYS FFYQLEGEPW KPCSLHQAPT
110 120 130 140 150
AHGAVRFWCS LPTADTSSFV PLELRVTAVS SGAPRYRRII HINEVVLLDP
160 170 180 190 200
PTGLLARRAD EGGHVVLRWL PPPGAPVASL IRYEVNISSG NIAAGAQKVE
210 220 230 240 250
ILDGRTECLL SNLRGRTRYT FMVRARMAEP SFGGFWSAWS EPASLLTVSD
260 270 280 290 300
LDPLILTLSL ILVLILLLLA VLALLSHRRA LKQKIWPGIP SPESEFEGLF
310 320 330 340 350
TTHKGNFQLW LYQNEGCLWW SPCTPFAEDP PAPLEVLSER CWGATQAVEP
360 370 380 390 400
GTEDEGPLLE PVGSEHTQDT YLVLDKWLLP RNPPTEDLPR PDGGLDMVAM
410 420 430 440 450
DKGSEASSYS SALSLKPGPE GALGTSFEYT ILDPSSQLLR PRALPPELPP
460 470 480 490 500
TPPHIKYLYL MVSDSGISTD YSSGGSQGAQ GDSSNGPFSN PYENSLSPAL
510
EPSPPSYVAC S
Length:511
Mass (Da):55,650
Last modified:May 1, 2013 - v1
Checksum:i83B60622212B0CF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01024474 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMPUT00000005484; ENSMPUP00000005395; ENSMPUG00000005434

Similar proteinsi

Entry informationi

Entry nameiM3Y244_MUSPF
AccessioniPrimary (citable) accession number: M3Y244
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: March 28, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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