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Protein
Submitted name:

Calcium sensing receptor

Gene

CASR

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium sensing receptorImported
Gene namesi
Name:CASRImported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei612 – 637HelicalSequence analysisAdd BLAST26
Transmembranei649 – 670HelicalSequence analysisAdd BLAST22
Transmembranei682 – 704HelicalSequence analysisAdd BLAST23
Transmembranei725 – 744HelicalSequence analysisAdd BLAST20
Transmembranei770 – 792HelicalSequence analysisAdd BLAST23
Transmembranei804 – 826HelicalSequence analysisAdd BLAST23
Transmembranei832 – 854HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500404414820 – 1082Sequence analysisAdd BLAST1063

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000004759.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini612 – 876G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST265

Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
InParanoidiM3Y0A8.
OMAiGYTCLLA.
OrthoDBiEOG091G01NA.

Family and domain databases

Gene3Di2.10.50.30. 1 hit.
InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR038550. GPCR_3_9-Cys_sf.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.

Sequencei

Sequence statusi: Complete.

M3Y0A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFYSCCFIL LASTWCTSAY GPDQRAQKKG DIILGGLFPI HFGVAAKDQD
60 70 80 90 100
LKSRPESVEC IRYNFRGFRW LQAMIFAIEE INSSPALLPN MTLGYRIFDT
110 120 130 140 150
CNTVSKALEA TLSFVAQNKI DSLNLDEFCN CSEHIPSTIA VVGATGSGIS
160 170 180 190 200
TAVANLLGLF YIPQVSYASS SRLLSNKNQF KSFLRTIPND EHQATAMADI
210 220 230 240 250
IEYFRWNWVG TIAADDDYGR PGIEKFREEA EERDICIDFS ELISQYSDEE
260 270 280 290 300
EIQQVVEVIQ NSTAKVIVVF SSGPDLEPLI KEIVRRNITG RIWLASEAWA
310 320 330 340 350
SSSLIAMPEY FHVVGGTIGF ALKAGKIPGF REFLQKVHPR KSVHNGFAKE
360 370 380 390 400
FWEETFNCHL QEGAKGALSM DTFMRGHEEG GGRISNSSTA FRPLCTGDEN
410 420 430 440 450
ISSVETPYMD YTHLRISYNV YLAVYSIAHA LQDIYTCLPG RGLFTNGSCA
460 470 480 490 500
DIKKVEAWQV LKHLRHLNFT NNMGEQVTFD ECGDLMGNYS IINWHLSPED
510 520 530 540 550
GSIVFKEVGY YNVYAKKGER LFINEEKILW SGFSREVPFS NCSRDCLAGT
560 570 580 590 600
RKGIIEGEPT CCFECVECPD GEYSDETDAS ACDKCPDDFW SNENHTSCIA
610 620 630 640 650
KEIEFLSWTE PFGIALTLFA VLGIFLTAFV LGVFIKFRNT PIVKATNREL
660 670 680 690 700
SYLLLFSLLC CFSSSLFFIG EPQDWTCRLR QPAFGISFVL CISCILVKTN
710 720 730 740 750
RVLLVFEAKI PTSFHRKWWG LNLQFLLVFL CTFMQIVICV IWLYTAPPSS
760 770 780 790 800
YRNHELEDEI IFITCHEGSL MALGFLIGYT CLLAAICFFF AFKSRKLPEN
810 820 830 840 850
FNEAKFITFS MLIFFIVWIS FIPAYASTYG KFVSAVEVIA ILAASFGLLA
860 870 880 890 900
CIFFNKVYII LFKPSRNTIE EVRCSTAAHA FKVAARATLR RSNVSRKRSS
910 920 930 940 950
SLGGSTGSTP SSSISSKSNS EDPFPQPERQ KQQQQPLALT QQEQQPQQPL
960 970 980 990 1000
TLQQQPQPQP QPQPRCKQKV IFGSGTVTFS LSFDEPQKSA MAHRNSTHQN
1010 1020 1030 1040 1050
SLEAQRSNET LSRHQALLPL QCGETDSELT VQETGLQGPV GGDHRPETED
1060 1070 1080
PEEMSPALVV SSSQSFVISS GGSTVTENIL HS
Length:1,082
Mass (Da):121,080
Last modified:May 1, 2013 - v1
Checksum:i8A1FD6E9630C7899
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01017712 Genomic DNA. No translation available.
AEYP01017713 Genomic DNA. No translation available.
RefSeqiXP_004745527.1. XM_004745470.2.
XP_012908139.1. XM_013052685.1.
XP_012908140.1. XM_013052686.1.
XP_012908141.1. XM_013052687.1.
XP_012908142.1. XM_013052688.1.

Genome annotation databases

EnsembliENSMPUT00000004842; ENSMPUP00000004759; ENSMPUG00000004798.
GeneIDi101686145.

Similar proteinsi

Entry informationi

Entry nameiM3Y0A8_MUSPF
AccessioniPrimary (citable) accession number: M3Y0A8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported