ID   M3XLW7_MUSPF            Unreviewed;       209 AA.
AC   M3XLW7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=COP9 signalosome complex subunit 8 {ECO:0000256|ARBA:ARBA00014875};
GN   Name=COPS8 {ECO:0000313|RefSeq:XP_004743728.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000067.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000000067.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004743728.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004743728.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CSN8 family.
CC       {ECO:0000256|ARBA:ARBA00008252}.
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DR   EMBL; AEYP01014285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004743728.1; XM_004743671.3.
DR   STRING; 9669.ENSMPUP00000000067; -.
DR   Ensembl; ENSMPUT00000000068.1; ENSMPUP00000000067.1; ENSMPUG00000000068.1.
DR   GeneID; 101677249; -.
DR   KEGG; mpuf:101677249; -.
DR   CTD; 10920; -.
DR   eggNOG; KOG4414; Eukaryota.
DR   GeneTree; ENSGT00390000000977; -.
DR   HOGENOM; CLU_098091_1_1_1; -.
DR   OMA; NNAKFLW; -.
DR   OrthoDB; 3675131at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   Gene3D; 1.25.40.990; -; 1.
DR   InterPro; IPR033205; COP9_CSN8.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13339; COP9 SIGNALOSOME COMPLEX SUBUNIT 8; 1.
DR   PANTHER; PTHR13339:SF0; COP9 SIGNALOSOME COMPLEX SUBUNIT 8; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Signalosome {ECO:0000256|ARBA:ARBA00022790}.
FT   DOMAIN          8..186
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|PROSITE:PS50250"
SQ   SEQUENCE   209 AA;  23216 MW;  893663737011672E CRC64;
     MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI
     PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL
     VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVMPKKPVAG ALDASFNRFI
     PLSEPAPVPP IPNEQQLARL TDYVAFLEN
//