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Protein

Neuropilin

Gene

NRP1

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi196CalciumUniRule annotation1
Metal bindingi210CalciumUniRule annotation1
Metal bindingi251CalciumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, ReceptorUniRule annotation
Biological processDifferentiationUniRule annotation, NeurogenesisUniRule annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NeuropilinUniRule annotation
Gene namesi
Name:NRP1Imported
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)Imported
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
Proteomesi
  • UP000008672 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei862 – 887HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500404386121 – 928NeuropilinSequence analysisAdd BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55UniRule annotation
Disulfide bondi83 ↔ 105UniRule annotation
Disulfide bondi148 ↔ 174UniRule annotation
Disulfide bondi207 ↔ 229UniRule annotation
Disulfide bondi276 ↔ 425UniRule annotation
Disulfide bondi432 ↔ 583UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7897.ENSLACP00000023533.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 142CUBInterPro annotationAdd BLAST115
Domaini148 – 266CUBInterPro annotationAdd BLAST119
Domaini276 – 425F5/8 type CInterPro annotationAdd BLAST150
Domaini432 – 583F5/8 type CInterPro annotationAdd BLAST152
Domaini648 – 817MAMInterPro annotationAdd BLAST170

Sequence similaritiesi

Belongs to the neuropilin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IE8T. Eukaryota.
ENOG410YRBE. LUCA.
GeneTreeiENSGT00760000119073.
InParanoidiM3XLC7.
OMAiLYCACWH.
OrthoDBiEOG091G017M.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like_sf.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin_C.
IPR027146. NRP1.
IPR035914. Sperma_CUB_dom_sf.
PANTHERiPTHR44185. PTHR44185. 1 hit.
PTHR44185:SF1. PTHR44185:SF1. 1 hit.
PfamiView protein in Pfam
PF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiView protein in SMART
SM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS01180. CUB. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

M3XLC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRMYFGFLL HCLCMTIITA KTIKNDKCGD NIRITAPGYL TSPGYPHTYQ
60 70 80 90 100
QYQECIWVIH ATENNQRIMI NFNPHFDLED RDCKYDYVEV RDGGDEHAHL
110 120 130 140 150
LGKFCGKIAP SVVLSTGPQM FIKFVSDYET HGAGFSIRYE VFKTGPECSR
160 170 180 190 200
NFTTSSGVIK SPGFPEKYTN NLECTYIIFA PKMAEIIVEF ESFELEPDTT
210 220 230 240 250
SPGGMFCRYD RLEIWDGLPG IGPHIGRYCG QSTPGRIQSF TGILSMTLHT
260 270 280 290 300
DSAIAKEGFS ANFTTIQRII PEDFECLEPL GMESGEIHPD RIIPSSQYNF
310 320 330 340 350
NWSAEKARLN FPENAWTPST DSSKEWIQVD LGFLRYLSAI GTQGAISKET
360 370 380 390 400
KKVYFVTKYK VDVSTNGEDW VTLKEASKQI EFQGNTSPTE TALSKLPKPT
410 420 430 440 450
LTRFVRIRPI SWDGGIALRF ELYGCKITDY PCSGMLGMIS GLIADSQITV
460 470 480 490 500
STPDRNWIPE NARLVNSRSV WSLPPSSHPY RNEWLQIDLG EEKLVSGFIV
510 520 530 540 550
QGGKHRDKKV FMRKFKIGYS NNGSDWKMIK SANGNRIKSF EGNTNYDTPE
560 570 580 590 600
RRTFEPILSR FFRIYPERGV PSGLGLRLEL LGCEIEAPTS TPTSSEASLT
610 620 630 640 650
DECDDDQANC HSGTGDDTEM TDGIVLTTEE PTVMQVTEQP EDATVPGFNC
660 670 680 690 700
DFGWTIIQTI CSWQHDIYAD FKWSVQARTT PTSNTGPIRD RTGKGNYIYT
710 720 730 740 750
EAGGKQKGEV ARLVSPMILP RSSKQCMTFM YHMSGSHTGT LRVILKETRS
760 770 780 790 800
DTAKDHILWT RSGHQGNHWR EGRVVLPQLP DIYQVIIEGK VGKENLEGIA
810 820 830 840 850
VDDVQIADSV PLDDCYDPDE HHQQKPDTTD KTTISNNDPI DDASIGSHAE
860 870 880 890 900
SPGSVLKTLD PILITIIAMS ALGVLLGAIC GVVLYCACWH NGMAERNLSA
910 920
LENYNFELVD GVKLKKEKLN SQNSYSEA
Length:928
Mass (Da):103,911
Last modified:May 1, 2013 - v1
Checksum:iED1A3CC0B102FA16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01217321 Genomic DNA. No translation available.
AFYH01217322 Genomic DNA. No translation available.
AFYH01217323 Genomic DNA. No translation available.
AFYH01217324 Genomic DNA. No translation available.
AFYH01217325 Genomic DNA. No translation available.
AFYH01217326 Genomic DNA. No translation available.
AFYH01217327 Genomic DNA. No translation available.
AFYH01217328 Genomic DNA. No translation available.
AFYH01217329 Genomic DNA. No translation available.
RefSeqiXP_014352765.1. XM_014497279.1.

Genome annotation databases

EnsembliENSLACT00000026028; ENSLACP00000023533; ENSLACG00000002208.
GeneIDi102358374.

Similar proteinsi

Entry informationi

Entry nameiM3XLC7_LATCH
AccessioniPrimary (citable) accession number: M3XLC7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: December 20, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported