Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropilin

Gene

NRP1

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi196CalciumUniRule annotation1
Metal bindingi210CalciumUniRule annotation1
Metal bindingi251CalciumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, ReceptorUniRule annotation
Biological processDifferentiationUniRule annotation, NeurogenesisUniRule annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NeuropilinUniRule annotation
Gene namesi
Name:NRP1Imported
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)Imported
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
Proteomesi
  • UP000008672 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei862 – 887HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500404386121 – 928NeuropilinSequence analysisAdd BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55UniRule annotation
Disulfide bondi83 ↔ 105UniRule annotation
Disulfide bondi148 ↔ 174UniRule annotation
Disulfide bondi207 ↔ 229UniRule annotation
Disulfide bondi276 ↔ 425UniRule annotation
Disulfide bondi432 ↔ 583UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7897.ENSLACP00000023533

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 142CUBInterPro annotationAdd BLAST115
Domaini148 – 266CUBInterPro annotationAdd BLAST119
Domaini276 – 425F5/8 type CInterPro annotationAdd BLAST150
Domaini432 – 583F5/8 type CInterPro annotationAdd BLAST152
Domaini648 – 817MAMInterPro annotationAdd BLAST170

Sequence similaritiesi

Belongs to the neuropilin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IE8T Eukaryota
ENOG410YRBE LUCA
GeneTreeiENSGT00910000143988
InParanoidiM3XLC7
OMAiLYCACWH
OrthoDBiEOG091G017M

Family and domain databases

CDDicd00041 CUB, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR44185 PTHR44185, 1 hit
PTHR44185:SF1 PTHR44185:SF1, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
PRINTSiPR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit

Sequencei

Sequence statusi: Complete.

M3XLC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRMYFGFLL HCLCMTIITA KTIKNDKCGD NIRITAPGYL TSPGYPHTYQ
60 70 80 90 100
QYQECIWVIH ATENNQRIMI NFNPHFDLED RDCKYDYVEV RDGGDEHAHL
110 120 130 140 150
LGKFCGKIAP SVVLSTGPQM FIKFVSDYET HGAGFSIRYE VFKTGPECSR
160 170 180 190 200
NFTTSSGVIK SPGFPEKYTN NLECTYIIFA PKMAEIIVEF ESFELEPDTT
210 220 230 240 250
SPGGMFCRYD RLEIWDGLPG IGPHIGRYCG QSTPGRIQSF TGILSMTLHT
260 270 280 290 300
DSAIAKEGFS ANFTTIQRII PEDFECLEPL GMESGEIHPD RIIPSSQYNF
310 320 330 340 350
NWSAEKARLN FPENAWTPST DSSKEWIQVD LGFLRYLSAI GTQGAISKET
360 370 380 390 400
KKVYFVTKYK VDVSTNGEDW VTLKEASKQI EFQGNTSPTE TALSKLPKPT
410 420 430 440 450
LTRFVRIRPI SWDGGIALRF ELYGCKITDY PCSGMLGMIS GLIADSQITV
460 470 480 490 500
STPDRNWIPE NARLVNSRSV WSLPPSSHPY RNEWLQIDLG EEKLVSGFIV
510 520 530 540 550
QGGKHRDKKV FMRKFKIGYS NNGSDWKMIK SANGNRIKSF EGNTNYDTPE
560 570 580 590 600
RRTFEPILSR FFRIYPERGV PSGLGLRLEL LGCEIEAPTS TPTSSEASLT
610 620 630 640 650
DECDDDQANC HSGTGDDTEM TDGIVLTTEE PTVMQVTEQP EDATVPGFNC
660 670 680 690 700
DFGWTIIQTI CSWQHDIYAD FKWSVQARTT PTSNTGPIRD RTGKGNYIYT
710 720 730 740 750
EAGGKQKGEV ARLVSPMILP RSSKQCMTFM YHMSGSHTGT LRVILKETRS
760 770 780 790 800
DTAKDHILWT RSGHQGNHWR EGRVVLPQLP DIYQVIIEGK VGKENLEGIA
810 820 830 840 850
VDDVQIADSV PLDDCYDPDE HHQQKPDTTD KTTISNNDPI DDASIGSHAE
860 870 880 890 900
SPGSVLKTLD PILITIIAMS ALGVLLGAIC GVVLYCACWH NGMAERNLSA
910 920
LENYNFELVD GVKLKKEKLN SQNSYSEA
Length:928
Mass (Da):103,911
Last modified:May 1, 2013 - v1
Checksum:iED1A3CC0B102FA16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01217321 Genomic DNA No translation available.
AFYH01217322 Genomic DNA No translation available.
AFYH01217323 Genomic DNA No translation available.
AFYH01217324 Genomic DNA No translation available.
AFYH01217325 Genomic DNA No translation available.
AFYH01217326 Genomic DNA No translation available.
AFYH01217327 Genomic DNA No translation available.
AFYH01217328 Genomic DNA No translation available.
AFYH01217329 Genomic DNA No translation available.
RefSeqiXP_014352765.1, XM_014497279.1

Genome annotation databases

EnsembliENSLACT00000026028; ENSLACP00000023533; ENSLACG00000002208
GeneIDi102358374

Similar proteinsi

Entry informationi

Entry nameiM3XLC7_LATCH
AccessioniPrimary (citable) accession number: M3XLC7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health