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Protein

Histone-lysine N-methyltransferase SETD7

Gene

SETD7

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei245SubstrateUniRule annotation1
Binding sitei317SubstrateUniRule annotation1
Binding sitei335Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei356S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandS-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD7UniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
SET domain-containing protein 7UniRule annotation
Gene namesi
Name:SETD7Imported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome B1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSFCAG00000015075.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000013984.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 336SETInterPro annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni226 – 228S-adenosyl-L-methionine bindingUniRule annotation3
Regioni256 – 258Substrate bindingUniRule annotation3
Regioni266 – 268Substrate bindingUniRule annotation3
Regioni296 – 297S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1079. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00390000004827.
InParanoidiM3WLW3.
OMAiGSSVYHF.
OrthoDBiEOG091G08JN.

Family and domain databases

InterProiView protein in InterPro
IPR017155. Hist-Lys_N-MeTrfase_SET.
IPR003409. MORN.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF02493. MORN. 4 hits.
PF00856. SET. 1 hit.
PIRSFiPIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51577. SAM_MT43_SET7. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

M3WLW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK
60 70 80 90 100
FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT
110 120 130 140 150
DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD
160 170 180 190 200
ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGSSV YHFDKSTSSC
210 220 230 240 250
ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI
260 270 280 290 300
THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT
310 320 330 340 350
PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP
360
EWYQVELKAF QATQQK
Length:366
Mass (Da):40,694
Last modified:May 1, 2013 - v1
Checksum:i43BC28F6AB014C6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG02062847 Genomic DNA. No translation available.
AANG02062849 Genomic DNA. No translation available.
AANG02062850 Genomic DNA. No translation available.
AANG02062851 Genomic DNA. No translation available.
AANG02062852 Genomic DNA. No translation available.
AANG02062853 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSFCAT00000015080; ENSFCAP00000013984; ENSFCAG00000015075.

Similar proteinsi

Entry informationi

Entry nameiM3WLW3_FELCA
AccessioniPrimary (citable) accession number: M3WLW3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: September 27, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported