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M3WLW3

- M3WLW3_FELCA

UniProt

M3WLW3 - M3WLW3_FELCA

Protein

Histone-lysine N-methyltransferase SETD7

Gene

SETD7

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (01 May 2013)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidyl-lysine dimethylation Source: Ensembl
    2. peptidyl-lysine monomethylation Source: Ensembl
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ActivatorUniRule annotation, Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SETD7UniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    SET domain-containing protein 7UniRule annotation
    Gene namesi
    Name:SETD7Imported
    OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome B1

    Subcellular locationi

    Nucleus UniRule annotation. Chromosome UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.UniRule annotation
    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000004827.
    KOiK11431.
    OMAiGSSVYHF.
    OrthoDBiEOG7M98G8.

    Family and domain databases

    InterProiIPR017155. Hist-Lys_N-MeTrfase_SET.
    IPR003409. MORN.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF02493. MORN. 4 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51577. SAM_MT43_SET7. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    M3WLW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK    50
    FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT 100
    DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD 150
    ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGSSV YHFDKSTSSC 200
    ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI 250
    THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT 300
    PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP 350
    EWYQVELKAF QATQQK 366
    Length:366
    Mass (Da):40,694
    Last modified:May 1, 2013 - v1
    Checksum:i43BC28F6AB014C6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AANG02062847 Genomic DNA. No translation available.
    AANG02062849 Genomic DNA. No translation available.
    AANG02062850 Genomic DNA. No translation available.
    AANG02062851 Genomic DNA. No translation available.
    AANG02062852 Genomic DNA. No translation available.
    AANG02062853 Genomic DNA. No translation available.
    RefSeqiXP_003985041.1. XM_003984992.2.

    Genome annotation databases

    EnsembliENSFCAT00000015080; ENSFCAP00000013984; ENSFCAG00000015075.
    GeneIDi101091191.
    KEGGifca:101091191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AANG02062847 Genomic DNA. No translation available.
    AANG02062849 Genomic DNA. No translation available.
    AANG02062850 Genomic DNA. No translation available.
    AANG02062851 Genomic DNA. No translation available.
    AANG02062852 Genomic DNA. No translation available.
    AANG02062853 Genomic DNA. No translation available.
    RefSeqi XP_003985041.1. XM_003984992.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000015080 ; ENSFCAP00000013984 ; ENSFCAG00000015075 .
    GeneIDi 101091191.
    KEGGi fca:101091191.

    Organism-specific databases

    CTDi 80854.

    Phylogenomic databases

    GeneTreei ENSGT00390000004827.
    KOi K11431.
    OMAi GSSVYHF.
    OrthoDBi EOG7M98G8.

    Family and domain databases

    InterProi IPR017155. Hist-Lys_N-MeTrfase_SET.
    IPR003409. MORN.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF02493. MORN. 4 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51577. SAM_MT43_SET7. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AbyssinianImported.
    2. "Sequence assembly of the Felis catus genome version 6.2."
      Hillier L.W., Warren W., Obrien S., Wilson R.K.
      Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AbyssinianImported.
    3. Ensembl
      Submitted (MAR-2013) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: breed AbyssinianImported.

    Entry informationi

    Entry nameiM3WLW3_FELCA
    AccessioniPrimary (citable) accession number: M3WLW3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2013
    Last sequence update: May 1, 2013
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3