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M3WLW3 (M3WLW3_FELCA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SETD7 PIRNR PIRNR037249

EC=2.1.1.43 PIRNR PIRNR037249
Alternative name(s):
SET domain-containing protein 7 PIRNR PIRNR037249
Gene names
Name:SETD7 Ensembl ENSFCAP00000013984
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome] Ensembl ENSFCAP00000013984
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes By similarity. PIRNR PIRNR037249

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR037249

Subcellular location

Nucleus. Chromosome By similarity PIRNR PIRNR037249.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily. PIRNR PIRNR037249

Contains 1 SET domain. RuleBase RU004538

Contains SET domain. SAAS SAAS001214

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSFCAP00000013984

Sequences

Sequence LengthMass (Da)Tools
M3WLW3 [UniParc].

Last modified May 1, 2013. Version 1.
Checksum: 43BC28F6AB014C6A

FASTA36640,694
        10         20         30         40         50         60 
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE 

        70         80         90        100        110        120 
GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW 

       130        140        150        160        170        180 
IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP 

       190        200        210        220        230        240 
HFELMPGSSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT 

       250        260        270        280        290        300 
VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT 

       310        320        330        340        350        360 
PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF 


QATQQK 

« Hide

References

« Hide 'large scale' references
[1]"Initial sequence and comparative analysis of the cat genome."
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A., Menotti-Raymond M. expand/collapse author list , Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.
Genome Res. 17:1675-1689(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Abyssinian Ensembl ENSFCAP00000013984.
[2]"Sequence assembly of the Felis catus genome version 6.2."
Hillier L.W., Warren W., Obrien S., Wilson R.K.
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Abyssinian Ensembl ENSFCAP00000013984.
[3]Ensembl
Submitted (MAR-2013) to UniProtKB
Cited for: IDENTIFICATION.
Strain: breed Abyssinian Ensembl ENSFCAP00000013984.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AANG02062847 Genomic DNA. No translation available.
AANG02062849 Genomic DNA. No translation available.
AANG02062850 Genomic DNA. No translation available.
AANG02062851 Genomic DNA. No translation available.
AANG02062852 Genomic DNA. No translation available.
AANG02062853 Genomic DNA. No translation available.
RefSeqXP_003985041.1. XM_003984992.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSFCAT00000015080; ENSFCAP00000013984; ENSFCAG00000015075.
GeneID101091191.
KEGGfca:101091191.

Organism-specific databases

CTD80854.

Phylogenomic databases

GeneTreeENSGT00390000004827.
KOK11431.
OMAGSSVYHF.
OrthoDBEOG7M98G8.

Family and domain databases

InterProIPR017155. Hist-Lys_N-MeTrfase_SET.
IPR003409. MORN.
IPR001214. SET_dom.
[Graphical view]
PfamPF02493. MORN. 4 hits.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFPIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
SMARTSM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51577. SAM_MT43_SET7. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameM3WLW3_FELCA
AccessionPrimary (citable) accession number: M3WLW3
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: July 9, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)