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M3WLW3

- M3WLW3_FELCA

UniProt

M3WLW3 - M3WLW3_FELCA

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Protein
Histone-lysine N-methyltransferase SETD7
Gene
SETD7
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. peptidyl-lysine dimethylation Source: Ensembl
  2. peptidyl-lysine monomethylation Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation, Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD7UniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
SET domain-containing protein 7
Gene namesi
Name:SETD7Imported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome B1

Subcellular locationi

Nucleus. Chromosome By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00390000004827.
KOiK11431.
OMAiGSSVYHF.
OrthoDBiEOG7M98G8.

Family and domain databases

InterProiIPR017155. Hist-Lys_N-MeTrfase_SET.
IPR003409. MORN.
IPR001214. SET_dom.
[Graphical view]
PfamiPF02493. MORN. 4 hits.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51577. SAM_MT43_SET7. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

M3WLW3-1 [UniParc]FASTAAdd to Basket

« Hide

MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK    50
FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT 100
DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD 150
ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGSSV YHFDKSTSSC 200
ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI 250
THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT 300
PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP 350
EWYQVELKAF QATQQK 366
Length:366
Mass (Da):40,694
Last modified:May 1, 2013 - v1
Checksum:i43BC28F6AB014C6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AANG02062847 Genomic DNA. No translation available.
AANG02062849 Genomic DNA. No translation available.
AANG02062850 Genomic DNA. No translation available.
AANG02062851 Genomic DNA. No translation available.
AANG02062852 Genomic DNA. No translation available.
AANG02062853 Genomic DNA. No translation available.
RefSeqiXP_003985041.1. XM_003984992.2.

Genome annotation databases

EnsembliENSFCAT00000015080; ENSFCAP00000013984; ENSFCAG00000015075.
GeneIDi101091191.
KEGGifca:101091191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AANG02062847 Genomic DNA. No translation available.
AANG02062849 Genomic DNA. No translation available.
AANG02062850 Genomic DNA. No translation available.
AANG02062851 Genomic DNA. No translation available.
AANG02062852 Genomic DNA. No translation available.
AANG02062853 Genomic DNA. No translation available.
RefSeqi XP_003985041.1. XM_003984992.2.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000015080 ; ENSFCAP00000013984 ; ENSFCAG00000015075 .
GeneIDi 101091191.
KEGGi fca:101091191.

Organism-specific databases

CTDi 80854.

Phylogenomic databases

GeneTreei ENSGT00390000004827.
KOi K11431.
OMAi GSSVYHF.
OrthoDBi EOG7M98G8.

Family and domain databases

InterProi IPR017155. Hist-Lys_N-MeTrfase_SET.
IPR003409. MORN.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF02493. MORN. 4 hits.
PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51577. SAM_MT43_SET7. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AbyssinianImported.
  2. "Sequence assembly of the Felis catus genome version 6.2."
    Hillier L.W., Warren W., Obrien S., Wilson R.K.
    Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AbyssinianImported.
  3. Ensembl
    Submitted (MAR-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: breed AbyssinianImported.

Entry informationi

Entry nameiM3WLW3_FELCA
AccessioniPrimary (citable) accession number: M3WLW3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: July 9, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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