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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 1

Gene

PCSK1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS08.072

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 1Imported
Gene namesi
Name:PCSK1Imported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome A1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSFCAG00000006327

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000005882

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini460 – 597P/Homo BInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00750000117358
InParanoidiM3W5Q0
KOiK01359
OMAiFEPRALK
OrthoDBiEOG091G05HI

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022005 Proho_convert
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF12177 Proho_convert, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

M3W5Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRAWTLQC TAFALFCAWY ALNSVKAKRQ FVNEWAAEIP GGPEAASAIA
60 70 80 90 100
EELGYDLLGQ IGSLENHYLF KHKNHPRRSR RSAFHITKRL SDDDRVIWAE
110 120 130 140 150
QQYEKERSKR SVLRDSALNL FNDPMWNQQW YLQDTRMTAS LPKLDLHVIP
160 170 180 190 200
VWQKGITGKG VVITVLDDGL EWNHTDIYAN YDPEASYDFN DNDHDPFPRY
210 220 230 240 250
DPTNENKHGT RCAGEIAMQA NNHKCGVGVA YNSKVGGIRM LDGIVTDAIE
260 270 280 290 300
ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEF GVKQGRQGKG
310 320 330 340 350
SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST
360 370 380 390 400
LATSYSSGDY TDQRITSADL HNDCTETHTG TSASAPLAAG IFALALEANP
410 420 430 440 450
NLTWRDMQHL VVWTSEYDPL ANNPGWKKNG AGLMVNSRFG FGLLNAKALV
460 470 480 490 500
DLADPRTWTS VPEKKECVVK DNEFEPRALK GNGEVIIEIP TRACEEQENA
510 520 530 540 550
IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TSTVLLAERE RDTSPNGFKN
560 570 580 590 600
WDFMSVHTWG ENPIGTWTLR ITDMSGRMQN EGRIVNWKLI FHGTSSQPEH
610 620 630 640 650
MKQPRVYTSY NTVQNDRRGV EKMVDLGEEQ PTQENPKKNP LMSKSPSGDS
660 670 680 690 700
TGDRRNELAE AAPSEAMLRL LQSAFNKNSP PKQSPKKPPS AKLNIPYETF
710 720 730 740 750
YEALEKLNKP SQLKESEDSL YNDYVDVFYN TKPYKHRDDR LLQALVDILR

EEN
Length:753
Mass (Da):84,460
Last modified:May 1, 2013 - v1
Checksum:i7D53EF813AB1BF56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG03324823 Genomic DNA No translation available.
AANG03324824 Genomic DNA No translation available.
RefSeqiXP_003981208.1, XM_003981159.4

Genome annotation databases

EnsembliENSFCAT00000006332; ENSFCAP00000005882; ENSFCAG00000006327
GeneIDi101082627
KEGGifca:101082627

Similar proteinsi

Entry informationi

Entry nameiM3W5Q0_FELCA
AccessioniPrimary (citable) accession number: M3W5Q0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health