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Protein

Pantothenate synthetase

Gene

panC

Organism
Leptospira interrogans serovar Grippotyphosa str. LT2186
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotationSAAS annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei61Beta-alanineUniRule annotation1
Binding sitei61PantoateUniRule annotation1
Binding sitei154PantoateUniRule annotation1
Binding sitei177ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi148 – 151ATPUniRule annotation4
Nucleotide bindingi185 – 188ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotationImported
ORF Names:LEP1GSC151_2834Imported
OrganismiLeptospira interrogans serovar Grippotyphosa str. LT2186Imported
Taxonomic identifieri1001599 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000011776 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiView protein in Pfam
PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

M3FRE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVCKTPEEV LDQVRLWKAQ GKRIGFVPTM GFLHEGHASL FEECISKADK
60 70 80 90 100
TVVSIFVNPA QFNDPEDYAK YPVNTEGDLK LCESKKVDLV FLPNKETIYP
110 120 130 140 150
DGIPDIVLKI PNLMKSLCAV SRPGHFEGVL LVISRLFHFV QPDFAFFGKK
160 170 180 190 200
DYQQYLLIRE FCNTLAFPIE VIGCETVRSS QGLALSSRNS RLSETEKEES
210 220 230 240 250
LLIYRSLKLG ENQIFSGIKN PLLVKEIMKD VLDSSSKIRL DYLEILNADT
260 270 280
LDPLEVLEGE ILLAIAAFIG PVRLIDNLTL SVPTS
Length:285
Mass (Da):32,011
Last modified:May 1, 2013 - v1
Checksum:i3FEE4B71B41856E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFME02000279 Genomic DNA. Translation: EMG10024.1.

Genome annotation databases

EnsemblBacteriaiEMG10024; EMG10024; LEP1GSC151_2834.

Similar proteinsi

Entry informationi

Entry nameiM3FRE8_LEPIR
AccessioniPrimary (citable) accession number: M3FRE8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: October 25, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported