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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Treponema denticola ATCC 35404
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90SubstrateUniRule annotation1
Binding sitei122NAD or substrateUniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1
Binding sitei233SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 42NADUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
ORF Names:HMPREF9721_01766Imported
OrganismiTreponema denticola ATCC 35404Imported
Taxonomic identifieri999430 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000011703 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224PhosphotyrosineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 144Ldh_1_NInterPro annotationAdd BLAST138
Domaini147 – 312Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

M2CMR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKKRKVTV VGAGAVGSTF AYALAQSGYA DEIAITDMNK NFAEGQALDL
60 70 80 90 100
VQGLPFLPQV DIHAGDKTDY ADSDIVVVTA GAKQQSGETR IDLLKRNASI
110 120 130 140 150
ITGIAKDIAE SGCSGVMLIV SNPVDILTRA ALKASGWERG RVIGSGTVLD
160 170 180 190 200
TARFRYTLSK EYGVDARNIH GYILGEHGDS EFAAWSMTSV AGRRIDEYCS
210 220 230 240 250
GGVCSSGPHF DKAKILEEVR NSAYHIIDYK GSTYFAVGLA LTRIAGAILR
260 270 280 290 300
NEHSILSVSM TLDGEFGLKD VCLSVPCIVG RSGAERVIES DLPADEQAAL
310
EASAKRLKEA FTEMN
Length:315
Mass (Da):33,663
Last modified:May 1, 2013 - v1
Checksum:i8FBDF082FBC9B189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGDU01000022 Genomic DNA Translation: EMB35484.1
RefSeqiWP_002681333.1, NZ_CM001796.1

Genome annotation databases

EnsemblBacteriaiEMB35484; EMB35484; HMPREF9721_01766
PATRICifig|999430.5.peg.1843

Similar proteinsi

Entry informationi

Entry nameiM2CMR8_TREDN
AccessioniPrimary (citable) accession number: M2CMR8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: March 28, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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