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Protein

Mitogen-activated protein kinase HOG1B

Gene

HOG1B

Organism
Wallemia ichthyophaga (strain EXF-994 / CBS 113033)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49ATPPROSITE-ProRule annotation1
Active sitei141Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1B (EC:2.7.11.24)
Short name:
MAP kinase HOG1B
Alternative name(s):
WiHog1B
Gene namesi
Name:HOG1B
ORF Names:J056_002786
OrganismiWallemia ichthyophaga (strain EXF-994 / CBS 113033)
Taxonomic identifieri1299270 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaWallemiomycetesWallemialesWallemiales incertae sedisWallemia
Proteomesi
  • UP000014064 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004291231 – 368Mitogen-activated protein kinase HOG1BAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphothreonineBy similarity1
Modified residuei173PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated. Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme (By similarity). Rapidly dephosphorylated upon either hypo- or hyperosmotic shock.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By hyperosmotic and hypo-osmotic stress.1 Publication

Structurei

3D structure databases

SMRiM1T7M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 299Protein kinasePROSITE-ProRule annotationAdd BLAST280

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi171 – 173TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Phylogenomic databases

KOiK04441

Family and domain databases

CDDicd07856 STKc_Sty1_Hog1, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008352 MAPK_p38-like
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01773 P38MAPKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

M1T7M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFVNASIF GTLFQITSRY VNLEPVGMGA FGLVCSAKDQ LTSSPVAIKK
60 70 80 90 100
IMKPFSTPVL SKRTYRELKL LKHIRHENII SLSDIFISPS EDIYFVTELL
110 120 130 140 150
GTDLHRLLTA RPLEKQFIQY FLYQILRGLK YVHSAGVVHR DLKPSNILVN
160 170 180 190 200
ENCDLKICDF GLARIQDPQM TGYVSTRYYR APEIMLTWQK YDVAVDIWST
210 220 230 240 250
GCIFAEMLEG KPLFPGKDHV NQFSIITELL GTPPDDVIQT ICSENTLRFV
260 270 280 290 300
QSLPKKPRIP FNEKFKTNDP LALDLVEKML SFDPRTRITA SQALAHPYLA
310 320 330 340 350
PYHDPNDEPV AAEQFDWSFN DADLPIDTWK VMMYSEILDF HHISQDGDQF
360
LNANGPGTEQ ASDSSFTV
Length:368
Mass (Da):41,837
Last modified:May 1, 2013 - v1
Checksum:i5CD34B27E78C63C9
GO

Sequence cautioni

The sequence EOQ98833 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX573533 Genomic DNA Translation: AGG39583.1
KE007249 Genomic DNA Translation: EOQ98833.1 Sequence problems.
RefSeqiXP_009270326.1, XM_009272051.1

Genome annotation databases

EnsemblFungiiEOQ98833; EOQ98833; J056_002786
GeneIDi20375738
KEGGiwic:J056_002786

Similar proteinsi

Entry informationi

Entry nameiHOG1B_WALI9
AccessioniPrimary (citable) accession number: M1T7M3
Secondary accession number(s): R9A9E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: May 1, 2013
Last modified: May 23, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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