ID   M1PPD1_HUMAN            Unreviewed;       317 AA.
AC   M1PPD1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   03-MAY-2023, entry version 21.
DE   SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|EMBL:AGF90791.1};
DE   Flags: Fragment;
GN   Name=MICA {ECO:0000313|EMBL:AGF90791.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AGF90791.1};
RN   [1] {ECO:0000313|EMBL:AGF90791.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zollikofer C., Fuerst D., Milnikel I., Richter A.;
RT   "A new variant of MICA*007:01.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KC171730; AGF90791.1; -; Genomic_DNA.
DR   AlphaFoldDB; M1PPD1; -.
DR   ChiTaRS; MICA; human.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd21017; IgC1_MHC_Ia_MIC-A_MIC-B; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   PANTHER; PTHR16675:SF154; MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE A-RELATED; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        286..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          183..272
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGF90791.1"
FT   NON_TER         317
FT                   /evidence="ECO:0000313|EMBL:AGF90791.1"
SQ   SEQUENCE   317 AA;  36170 MW;  49B8FE46B0220458 CRC64;
     PHSLRYNLTV LSWDGSVQSG FLAEVHLDGQ PFLRCDRQKC RAKPQGQWAE DVLGNKTWDR
     ETRDLTGNGK DLRMTLAHIK DQKEGLHSLQ EIRVCEIHED NSTRSSQHFY YDGELFLSQN
     LETEEWTMPQ SSRAQTLAMN VRNFLKEDAM KTKTHYHAMH ADCLQELRRY LKSGVVLRRT
     VPPMVNVTRS EASEGNITVT CRASGFYPWN ITLSWRQDGV SLSHDTQQWG DVLPDGNGTY
     QTWVATRICQ GEEQRFTCYM EHSGNHSTHP VPSGKVLVLQ SHWQTFHVSA VAAAAIFVII
     IFYVRCCKKK TSAAEGP
//