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Protein
Submitted name:

MHC class I polypeptide-related sequence A

Gene

MICA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I polypeptide-related sequence AImported
Gene namesi
Name:MICAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei286 – 304HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliM1PPD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 272Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST90

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

M1PPD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PHSLRYNLTV LSWDGSVQSG FLAEVHLDGQ PFLRCDRQKC RAKPQGQWAE
60 70 80 90 100
DVLGNKTWDR ETRDLTGNGK DLRMTLAHIK DQKEGLHSLQ EIRVCEIHED
110 120 130 140 150
NSTRSSQHFY YDGELFLSQN LETEEWTMPQ SSRAQTLAMN VRNFLKEDAM
160 170 180 190 200
KTKTHYHAMH ADCLQELRRY LKSGVVLRRT VPPMVNVTRS EASEGNITVT
210 220 230 240 250
CRASGFYPWN ITLSWRQDGV SLSHDTQQWG DVLPDGNGTY QTWVATRICQ
260 270 280 290 300
GEEQRFTCYM EHSGNHSTHP VPSGKVLVLQ SHWQTFHVSA VAAAAIFVII
310
IFYVRCCKKK TSAAEGP
Length:317
Mass (Da):36,170
Last modified:May 1, 2013 - v1
Checksum:i49B8FE46B0220458
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei317Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC171730 Genomic DNA. Translation: AGF90791.1.
UniGeneiHs.130838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC171730 Genomic DNA. Translation: AGF90791.1.
UniGeneiHs.130838.

3D structure databases

ProteinModelPortaliM1PPD1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiMICA. human.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM1PPD1_HUMAN
AccessioniPrimary (citable) accession number: M1PPD1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: November 2, 2016
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.