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Protein
Submitted name:

Pol protein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Pol proteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 145Peptidase A2InterPro annotationAdd BLAST70
Domaini199 – 389Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482. HIV_retropepsin_like. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiView protein in InterPro
IPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom_sf.
IPR034170. Retropepsin-like_cat_dom.
IPR018061. Retropepsins.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
PfamiView protein in Pfam
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.

Sequencei

Sequence statusi: Fragment.

M1IKT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FFRENLAFPQ GKAREFSSEQ ARADSPTSRD GWDGGRXNLL PEAGAEGQGA
60 70 80 90 100
ASSLSFPQIT LWQRPLVTVK IGGQLKEALL DTGADDTVFE NIDLQGRWKP
110 120 130 140 150
KMIGGIGGFI KVRQYDQILI EICGKRAIGT VLVGPTPVNI IGRNMLTQIG
160 170 180 190 200
CTLNFPISPI ETVPVALKPG MDGPKVKQWP LTEEKIKALT EICSEMEKEG
210 220 230 240 250
KISKIGPENP YNTPVFAIKK KDSTKWRKLV DFRELNKRTQ DFWEVQLGIP
260 270 280 290 300
HPAGLKKKKS VTXLDVGDAY FSVPLDESFR KYTAFTIPST NNEKPGVRYQ
310 320 330 340 350
YNVLPQGWKG SPAIFQSSMT KILDPFRAKN PEIIICQYVD DLYVGSDLEI
360 370 380 390 400
EQHRKKIEQL RAHLLSWGFY TPDKKHQKEP PFLWMGYELH PDKWTVQPIM
410 420 430 440 450
LPDKDSWTVN DIQKLVGKLN WASQIYAGIK VKQLCKLLRG AKALTDVVPL
460 470 480 490 500
TEEAELELAE NREILKEPVH GVYYDPTKDL IAELQKQGQG QWTYQIYQEP
510 520 530 540 550
GKNLKTGKYA RSKSAHTNDV KQLTEAVQKV ATESIVIWGK TPKFRLPIQK
560 570 580
ETWDTWWMEY WQATWIPEWE FVNTPPLVKL WYQL
Length:584
Mass (Da):66,592
Last modified:May 1, 2013 - v1
Checksum:iA9256D7111DD1D6A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Sequence uncertaintyi19E or QImported1
Non-terminal residuei584Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX983029 Genomic DNA. Translation: AGE82045.1.

Similar proteinsi

Entry informationi

Entry nameiM1IKT3_9HIV1
AccessioniPrimary (citable) accession number: M1IKT3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: November 22, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation