ID M1E1E4_9HIV1 Unreviewed; 59 AA. AC M1E1E4; DT 03-APR-2013, integrated into UniProtKB/TrEMBL. DT 03-APR-2013, sequence version 1. DT 27-MAR-2024, entry version 53. DE SubName: Full=Envelope glycoprotein {ECO:0000313|PDB:2LP7}; OS Human immunodeficiency virus 1. OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|PDB:2LP7}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0007829|PDB:2LP7, ECO:0007829|PDB:2M7W} RP STRUCTURE BY NMR. RX PubMed=24474763; DOI=10.1073/pnas.1309842111; RA Reardon P.N., Sage H., Dennison S.M., Martin J.W., Donald B.R., Alam S.M., RA Haynes B.F., Spicer L.D.; RT "Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 RT envelope membrane proximal region trimer."; RL Proc. Natl. Acad. Sci. U.S.A. 111:1391-1396(2014). RN [2] {ECO:0007829|PDB:5I08} RP STRUCTURE BY ELECTRON MICROSCOPY (4.04 ANGSTROMS) OF 15-28. RX PubMed=26935699; DOI=10.1038/nature17200; RA Kirchdoerfer R.N., Cottrell C.A., Wang N., Pallesen J., Yassine H.M., RA Turner H.L., Corbett K.S., Graham B.S., McLellan J.S., Ward A.B.; RT "Pre-fusion structure of a human coronavirus spike protein."; RL Nature 531:118-121(2016). RN [3] {ECO:0007829|PDB:5KWW} RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 1-28. RX PubMed=28761099; DOI=10.1038/s41467-017-00170-x; RA Roymans D., Alnajjar S.S., Battles M.B., Sitthicharoenchai P., RA Furmanova-Hollenstein P., Rigaux P., Berg J.V.D., Kwanten L., RA Ginderen M.V., Verheyen N., Vranckx L., Jaensch S., Arnoult E., RA Voorzaat R., Gallup J.M., Larios-Mora A., Crabbe M., Huntjens D., RA Raboisson P., Langedijk J.P., Ackermann M.R., McLellan J.S., Vendeville S., RA Koul A.; RT "Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor."; RL Nat. Commun. 8:167-167(2017). RN [4] {ECO:0007829|PDB:5U68} RP X-RAY CRYSTALLOGRAPHY (3.08 ANGSTROMS) OF 1-28. RX PubMed=28134915; DOI=10.1038/nmicrobiol.2016.272; RA Wen X., Mousa J.J., Bates J.T., Lamb R.A., Crowe J.E., Jardetzky T.S.; RT "Structural basis for antibody cross-neutralization of respiratory RT syncytial virus and human metapneumovirus."; RL Nat. Microbiol. 2:16272-16272(2017). RN [5] {ECO:0007829|PDB:6A0Z} RP X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) OF 1-28. RX PubMed=29925655; DOI=10.1128/JVI.00547-18; RA Lin Q., Li T., Chen Y., Lau S.Y., Wei M., Zhang Y., Zhang Z., Yao Q., RA Li J., Li Z., Wang D., Zheng Q., Yu H., Gu Y., Zhang J., Chen H., Li S., RA Xia N.; RT "Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 RT Influenza Virus. ."; RL J. Virol. 92:e00547-e00518(2018). RN [6] {ECO:0007829|PDB:6OUS} RP X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 1-28. RX PubMed=31515478; DOI=10.1038/s41467-019-12137-1; RA Tang A., Chen Z., Cox K.S., Su H.P., Callahan C., Fridman A., Zhang L., RA Patel S.B., Cejas P.J., Swoyer R., Touch S., Citron M.P., Govindarajan D., RA Luo B., Eddins M., Reid J.C., Soisson S.M., Galli J., Wang D., Wen Z., RA Heidecker G.J., Casimiro D.R., DiStefano D.J., Vora K.A.; RT "A potent broadly neutralizing human RSV antibody targets conserved site IV RT of the fusion glycoprotein."; RL Nat. Commun. 10:4153-4153(2019). RN [7] {ECO:0007829|PDB:6CXC} RP STRUCTURE BY ELECTRON MICROSCOPY (3.90 ANGSTROMS) OF 1-30. RX PubMed=30730999; DOI=10.1371/journal.pone.0210749; RA Xie Q., Wang Z., Ni F., Chen X., Ma J., Patel N., Lu H., Liu Y., Tian J.H., RA Flyer D., Massare M.J., Ellingsworth L., Glenn G., Smith G., Wang Q.; RT "Structure basis of neutralization by a novel site II/IV antibody against RT respiratory syncytial virus fusion protein."; RL PLoS ONE 14:e0210749-e0210749(2019). RN [8] {ECO:0007829|PDB:6DC3, ECO:0007829|PDB:6DC5} RP X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) OF 1-28. RX PubMed=31306469; DOI=10.1371/journal.ppat.1007944; RA Jones H.G., Battles M.B., Lin C.C., Bianchi S., Corti D., McLellan J.S.; RT "Alternative conformations of a major antigenic site on RSV F."; RL PLoS Pathog. 15:e1007944-e1007944(2019). RN [9] {ECO:0007829|PDB:6VKC, ECO:0007829|PDB:6VKD} RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1-28. RX PubMed=32407115; DOI=10.1021/acs.jmedchem.0c00226; RA Vendeville S., Tahri A., Hu L., Demin S., Cooymans L., Vos A., Kwanten L., RA Van den Berg J., Battles M.B., McLellan J.S., Koul A., Raboisson P., RA Roymans D., Jonckers T.H.M.; RT "Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2- RT yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2- RT one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of RT Respiratory Syncytial Virus."; RL J. Med. Chem. 63:8046-8058(2020). RN [10] {ECO:0007829|PDB:6W16} RP X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 1-28. RX PubMed=33035266; DOI=10.1371/journal.ppat.1008942; RA Huang J., Diaz D., Mousa J.J.; RT "Antibody recognition of the Pneumovirus fusion protein trimer interface."; RL PLoS Pathog. 16:e1008942-e1008942(2020). RN [11] {ECO:0007829|PDB:7AD1} RP STRUCTURE BY ELECTRON MICROSCOPY (2.92 ANGSTROMS) OF 1-28. RX PubMed=33431842; DOI=10.1038/s41467-020-20321-x; RA Juraszek J., Rutten L., Blokland S., Bouchier P., Voorzaat R., Ritschel T., RA Bakkers M.J.G., Renault L.L.R., Langedijk J.P.M.; RT "Stabilizing the closed SARS-CoV-2 spike trimer."; RL Nat. Commun. 12:244-244(2021). RN [12] {ECO:0007829|PDB:7FJN} RP STRUCTURE BY ELECTRON MICROSCOPY (3.25 ANGSTROMS) OF 1-28. RX PubMed=35291264; DOI=10.1016/j.isci.2022.104043; RA Liang Q., Wang Y., Zhang S., Sun J., Sun W., Li J., Liu Y., Li M., RA Cheng L., Jiang Y., Wang R., Zhang R., Yang Z., Ren Y., Chen P., Gao P., RA Yan H., Zhang Z., Zhang Q., Shi X., Wang J., Liu W., Wang X., Ying B., RA Zhao J., Qi H., Zhang L.; RT "RBD trimer mRNA vaccine elicits broad and protective immune responses RT against SARS-CoV-2 variants."; RL IScience 25:104043-104043(2022). RN [13] {ECO:0007829|PDB:7QTI} RP STRUCTURE BY ELECTRON MICROSCOPY (3.04 ANGSTROMS) OF 1-30. RX PubMed=35879526; DOI=10.1038/s41564-022-01198-6; RA Fenwick C., Turelli P., Ni D., Perez L., Lau K., Herate C., Marlin R., RA Lana E., Pellaton C., Raclot C., Esteves-Leuenberger L., Campos J., RA Farina A., Fiscalini F., Dereuddre-Bosquet N., Relouzat F., Abdelnabi R., RA Foo C.S., Neyts J., Leyssen P., Levy Y., Pojer F., Stahlberg H., RA LeGrand R., Trono D., Pantaleo G.; RT "Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron RT variants and confers full protection in monkeys."; RL Nat. Microbiol. 7:1376-1389(2022). RN [14] {ECO:0007829|PDB:8HFX} RP STRUCTURE BY ELECTRON MICROSCOPY (2.98 ANGSTROMS) OF 1-29. RX PubMed=37676003; DOI=10.1128/jvi.00505-23; RA Han P., Meng Y., Zhang D., Xu Z., Li Z., Pan X., Zhao Z., Li L., Tang L., RA Qi J., Liu K., Gao G.F.; RT "Structural basis of white-tailed deer, Odocoileus virginianus, ACE2 RT recognizing all the SARS-CoV-2 variants of concern with high affinity."; RL J. Virol. 97:e0050523-e0050523(2023). RN [15] {ECO:0007829|PDB:7ZRV} RP STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS) OF 1-30. RX PubMed=37100904; DOI=10.1038/s41586-023-05993-x; RA Gainza P., Wehrle S., Van Hall-Beauvais A., Marchand A., Scheck A., RA Harteveld Z., Buckley S., Ni D., Tan S., Sverrisson F., Goverde C., RA Turelli P., Raclot C., Teslenko A., Pacesa M., Rosset S., Georgeon S., RA Marsden J., Petruzzella A., Liu K., Xu Z., Chai Y., Han P., Gao G.F., RA Oricchio E., Fierz B., Trono D., Stahlberg H., Bronstein M., Correia B.E.; RT "De novo design of protein interactions with learned surface RT fingerprints."; RL Nature 617:176-184(2023). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PDB; 2LP7; NMR; -; A/B/C=1-59. DR PDB; 2M7W; NMR; -; A/B/C=1-59. DR PDB; 5I08; EM; 4.04 A; A/B/C=1-27. DR PDB; 5KWW; X-ray; 2.50 A; F=1-28. DR PDB; 5U68; X-ray; 3.08 A; A/B/C=1-28. DR PDB; 6A0Z; X-ray; 2.33 A; A=1-28. DR PDB; 6CXC; EM; 3.90 A; A/B/C/D/E/F=1-30. DR PDB; 6DC3; X-ray; 3.50 A; F=1-28. DR PDB; 6DC5; X-ray; 3.50 A; A/D/G=1-28. DR PDB; 6OUS; X-ray; 3.40 A; B/D/F/H/J/L=1-28. DR PDB; 6VKC; X-ray; 2.60 A; F=1-28. DR PDB; 6VKD; X-ray; 2.50 A; F=1-28. DR PDB; 6VKE; X-ray; 2.10 A; F=1-28. DR PDB; 6W16; X-ray; 3.10 A; F=1-28. DR PDB; 7AD1; EM; 2.92 A; A/B/C=1-28. DR PDB; 7FJN; EM; 3.25 A; A/B/C=1-28. DR PDB; 7QTI; EM; 3.04 A; A/D/K=1-30. DR PDB; 7ZRV; EM; 2.80 A; A/B/C=1-30. DR PDB; 8HFX; EM; 2.98 A; A/B/C=1-29. DR PDBsum; 2LP7; -. DR PDBsum; 2M7W; -. DR PDBsum; 5I08; -. DR PDBsum; 5KWW; -. DR PDBsum; 5U68; -. DR PDBsum; 6A0Z; -. DR PDBsum; 6CXC; -. DR PDBsum; 6DC3; -. DR PDBsum; 6DC5; -. DR PDBsum; 6OUS; -. DR EMDB; EMD-11719; -. DR EMDB; EMD-14141; -. DR EMDB; EMD-31624; -. DR EMDB; EMD-34727; -. DR EMDB; EMD-7774; -. DR SMR; M1E1E4; -. DR ABCD; M1E1E4; 4 sequenced antibodies. DR Gene3D; 1.10.287.210; -; 1. DR Gene3D; 6.20.230.10; -; 1. DR InterPro; IPR012473; Fibritin_C. DR Pfam; PF07921; Fibritin_C; 1. DR SUPFAM; SSF58046; Fibritin; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:2LP7, ECO:0007829|PDB:2M7W}. FT DOMAIN 1..26 FT /note="Fibritin C-terminal" FT /evidence="ECO:0000259|Pfam:PF07921" SQ SEQUENCE 59 AA; 7006 MW; A56FF6874FEF2B37 CRC64; GYIPEAPRDG QAYVRKDGEW VLLSTFLGSS GNEQELLELD KWASLWNWFN ITNWLWYIK //