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Protein
Submitted name:

Tyrosine-protein kinase receptor UFO

Gene

AXL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein kinase receptor UFOImported
Gene namesi
Name:AXLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:905. AXL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei182 – 20423HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiM0R0W6.

Expressioni

Gene expression databases

ExpressionAtlasiM0R0W6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301178.

Chemistry

BindingDBiM0R0W6.

Structurei

3D structure databases

ProteinModelPortaliM0R0W6.
SMRiM0R0W6. Positions 7-180, 223-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6363Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini68 – 16093Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini268 – 539272Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.
KOiK05115.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

M0R0W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIQAGEPDP PEEPLTSQAS VPPHQLRLGS LHPHTPYHIR VACTSSQGPS
60 70 80 90 100
SWTHWLPVET PEGVPLGPPE NISATRNGSQ AFVHWQEPRA PLQGTLLGYR
110 120 130 140 150
LAYQGQDTPE VLMDIGLRQE VTLELQGDGS VSNLTVCVAA YTAAGDGPWS
160 170 180 190 200
LPVPLEAWRP GQAQPVHQLV KEPSTPAFSW PWWYVLLGAV VAAACVLILA
210 220 230 240 250
LFLVHRRKKE TRYGEVFEPT VERGELVVRY RVRKSYSRRT TEATLNSLGI
260 270 280 290 300
SEELKEKLRD VMVDRHKVAL GKTLGEGEFG AVMEGQLNQD DSILKVAVKT
310 320 330 340 350
MKIAICTRSE LEDFLSEAVC MKEFDHPNVM RLIGVCFQGS ERESFPAPVV
360 370 380 390 400
ILPFMKHGDL HSFLLYSRLG DQPVYLPTQM LVKFMADIAS GMEYLSTKRF
410 420 430 440 450
IHRDLAARNC MLNENMSVCV ADFGLSKKIY NGDYYRQGRI AKMPVKWIAI
460 470 480 490 500
ESLADRVYTS KSDVWSFGVT MWEIATRGQT PYPGVENSEI YDYLRQGNRL
510 520 530 540 550
KQPADCLDGL YALMSRCWEL NPQDRPSFTE LREDLENTLK ALPPAQEPDE
560 570 580 590 600
ILYVNMDEGG GYPEPPGAAG GADPPTQPDP KDSCSCLTAA EVHPAGRYVL
610 620
CPSTTPSPAQ PADRGSPAAP GQEDGA
Length:626
Mass (Da):69,231
Last modified:April 3, 2013 - v1
Checksum:i66372173936B138F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011510 Genomic DNA. No translation available.
KF456581 Genomic DNA. No translation available.
KF456582 Genomic DNA. No translation available.
RefSeqiNP_001265528.1. NM_001278599.1.
UniGeneiHs.590970.

Genome annotation databases

EnsembliENST00000593513; ENSP00000471497; ENSG00000167601.
GeneIDi558.
KEGGihsa:558.
UCSCiuc032hxy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011510 Genomic DNA. No translation available.
KF456581 Genomic DNA. No translation available.
KF456582 Genomic DNA. No translation available.
RefSeqiNP_001265528.1. NM_001278599.1.
UniGeneiHs.590970.

3D structure databases

ProteinModelPortaliM0R0W6.
SMRiM0R0W6. Positions 7-180, 223-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301178.

Chemistry

BindingDBiM0R0W6.

Proteomic databases

PaxDbiM0R0W6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593513; ENSP00000471497; ENSG00000167601.
GeneIDi558.
KEGGihsa:558.
UCSCiuc032hxy.2. human.

Organism-specific databases

CTDi558.
HGNCiHGNC:905. AXL.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.
KOiK05115.

Miscellaneous databases

ChiTaRSiAXL. human.
GenomeRNAii558.

Gene expression databases

ExpressionAtlasiM0R0W6. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiM0R0W6_HUMAN
AccessioniPrimary (citable) accession number: M0R0W6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: May 11, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.