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Protein
Submitted name:

Interferon regulatory factor 3

Gene

IRF3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 3Imported
Gene namesi
Name:IRF3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6118. IRF3.

Expressioni

Gene expression databases

ExpressionAtlasiM0QYT9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310127.

Structurei

3D structure databases

SMRiM0QYT9. Positions 43-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXD8. Eukaryota.
ENOG410YA4B. LUCA.
GeneTreeiENSGT00760000119093.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
InterProiIPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF10401. IRF-3. 1 hit.
[Graphical view]
SMARTiSM01243. IRF-3. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.

Sequencei

Sequence statusi: Complete.

M0QYT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAPLPDPG PPSLAVAPEP CPQPLRSPSL DNPTPFPNLG PSENPLKRLL
60 70 80 90 100
VPGEEWEFEV TAFYRGRQVF QQTISCPEGL RLVGSEVGDR TLPGWPVTLP
110 120 130 140 150
DPGMSLTDRG VMSYVRHVLS CLGGGLALWR AGQWLWAQRL GHCHTYWAVS
160 170 180 190 200
EELLPNSGHG PDGEVPKDKE GGVFDLGPFI VDLITFTEGS GRSPRYALWF
210 220 230 240 250
CVGESWPQDQ PWTKRLVMVK VVPTCLRALV EMARVGGASS LENTVDLHIS
260 270 280
NSHPLSLTSD QYKAYLQDLV EGMDFQGPGE S
Length:281
Mass (Da):30,779
Last modified:April 3, 2013 - v1
Checksum:iBD1CD8A841ACF200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011495 Genomic DNA. No translation available.
RefSeqiNP_001184054.1. NM_001197125.1.
NP_001184055.1. NM_001197126.1.
UniGeneiHs.289052.
Hs.731922.
Hs.75254.

Genome annotation databases

EnsembliENST00000377135; ENSP00000366339; ENSG00000126456.
ENST00000593922; ENSP00000472601; ENSG00000126456.
ENST00000598808; ENSP00000472582; ENSG00000126456.
ENST00000599144; ENSP00000470069; ENSG00000126456.
GeneIDi3661.
UCSCiuc021uxp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011495 Genomic DNA. No translation available.
RefSeqiNP_001184054.1. NM_001197125.1.
NP_001184055.1. NM_001197126.1.
UniGeneiHs.289052.
Hs.731922.
Hs.75254.

3D structure databases

SMRiM0QYT9. Positions 43-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377135; ENSP00000366339; ENSG00000126456.
ENST00000593922; ENSP00000472601; ENSG00000126456.
ENST00000598808; ENSP00000472582; ENSG00000126456.
ENST00000599144; ENSP00000470069; ENSG00000126456.
GeneIDi3661.
UCSCiuc021uxp.2. human.

Organism-specific databases

CTDi3661.
HGNCiHGNC:6118. IRF3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXD8. Eukaryota.
ENOG410YA4B. LUCA.
GeneTreeiENSGT00760000119093.

Miscellaneous databases

ChiTaRSiIRF3. human.
GenomeRNAii3661.

Gene expression databases

ExpressionAtlasiM0QYT9. baseline and differential.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
InterProiIPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF10401. IRF-3. 1 hit.
[Graphical view]
SMARTiSM01243. IRF-3. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (NOV-2014) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiM0QYT9_HUMAN
AccessioniPrimary (citable) accession number: M0QYT9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: May 11, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.