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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Haloferax lucentense (strain DSM 14919 / JCM 9276 / NCIMB 13854 / Aa 2.2) (Haloferax alicantei)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159GTPUniRule annotation1
Binding sitei162GTPUniRule annotation1
Binding sitei205GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 45GTPUniRule annotation5
Nucleotide bindingi128 – 130GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
ORF Names:C456_15417Imported
OrganismiHaloferax lucentense (strain DSM 14919 / JCM 9276 / NCIMB 13854 / Aa 2.2) (Haloferax alicantei)Imported
Taxonomic identifieri1230452 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloferax
Proteomesi
  • UP000011535 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Structurei

3D structure databases

SMRiM0GGD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 223TubulinInterPro annotationAdd BLAST191
Domaini225 – 342Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

M0GGD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDIVREAME RDEAERQTQS SLEDSDDQFG DPRIVIVGAG GAGNNTINRL
60 70 80 90 100
YNIGVEGADT VAINTDKQHL KMIEADTKIL VGKSLTQGLG AGGDPSMGER
110 120 130 140 150
ATEMAQGTIK DVLGDADLVF VTAGMGGGTG TGAAPVVAKI AKEQGAIVVG
160 170 180 190 200
MVSTPFNVER ARTVKAEEGL ENLRNEADSI IVLDNNRLLD YVPNLPIGKA
210 220 230 240 250
FSVMDQIIAE TVKGISETIT QPSLINLDYA DMSTIMNQGG VAVMLVGETQ
260 270 280 290 300
DKNKTQEVVN DAMNHPLLDV DYRGASGGLV HITGGPDLTL KEAEGIASNI
310 320 330 340 350
TERLEAAANV IWGARIQDEY KGKVRVMAIM TGVQSAQVLG PSTQKQADKS
360 370 380 390 400
RQSIQSRESQ QQHSGSEFDS SERAQTAQSG TWSDGGRDEV EKNNGLDVIR
Length:400
Mass (Da):42,570
Last modified:April 3, 2013 - v1
Checksum:i2CCBBFF5AA4CA4DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AOLH01000025 Genomic DNA Translation: ELZ70572.1
RefSeqiWP_004044352.1, NZ_AOLH01000025.1

Genome annotation databases

EnsemblBacteriaiELZ70572; ELZ70572; C456_15417
GeneIDi8926446
PATRICifig|1230452.3.peg.3010

Similar proteinsi

Entry informationi

Entry nameiM0GGD5_HALL2
AccessioniPrimary (citable) accession number: M0GGD5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health