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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Haloferax sp. ATCC BAA-646
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei177GTPUniRule annotation1
Binding sitei181GTPUniRule annotation1
Binding sitei224GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 63GTPUniRule annotation5
Nucleotide bindingi146 – 148GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
ORF Names:C460_09125Imported
OrganismiHaloferax sp. ATCC BAA-646Imported
Taxonomic identifieri1227464 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloferax
Proteomesi
  • UP000011677 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 242TubulinInterPro annotationAdd BLAST192
Domaini244 – 361Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG093Z0942.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiView protein in InterPro
IPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR037103. Tubulin/FtsZ_C_sf.
IPR036525. Tubulin/FtsZ_GTPase_sf.
IPR003008. Tubulin_FtsZ_GTPase.
PfamiView protein in Pfam
PF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiView protein in PROSITE
PS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

M0FHC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSIVGDAID EAEAEDMGDE SAQVDGAANI NRSGTMTDDE LKAVLKDLQT
60 70 80 90 100
NITVVGCGGA GGNTVNRMHE EGIKGAKLVA ANTDVQHLVE IGADTKILMG
110 120 130 140 150
EQKTQGRGAG SLPQVGEEAA LESQEEIYDA IEGSDMVFVT AGLGGGTGTG
160 170 180 190 200
SAPVVAKAAR ESGALTIAIV TTPFTAEGEV RRTNAEAGLE RLRDVSDTVI
210 220 230 240 250
VVPNDRLLDA VGKLPVRQAF KVSDEVLMRS VKGITELITK PGLVNLDFAD
260 270 280 290 300
VKTVMERGGV AMIGLGESDS ESKAQESVKS ALRSPLLDVD ISGANSALVN
310 320 330 340 350
VTGGSDMSIE EAEGVVEEIY DRIDPDARII WGTSVDDELE GMMRTMIVVT
360 370
GVESPQIYGR NGEAQAQAEE RLEDIDYVE
Length:379
Mass (Da):39,796
Last modified:April 3, 2013 - v1
Checksum:iBFDEFBDDE1B00739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AOLD01000029 Genomic DNA. Translation: ELZ58733.1.
RefSeqiWP_004064924.1. NZ_AOLD01000029.1.

Genome annotation databases

EnsemblBacteriaiELZ58733; ELZ58733; C460_09125.
PATRICifig|1227464.4.peg.1807.

Similar proteinsi

Entry informationi

Entry nameiM0FHC8_9EURY
AccessioniPrimary (citable) accession number: M0FHC8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported