ID   L8IUK1_9CETA            Unreviewed;       732 AA.
AC   L8IUK1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=Coagulation factor XIII A chain {ECO:0000313|EMBL:ELR59683.1};
GN   ORFNames=E5288_WYG014887 {ECO:0000313|EMBL:MXQ96899.1}, M91_12590
GN   {ECO:0000313|EMBL:ELR59683.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR59683.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR59683.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YakQH1 {ECO:0000313|EMBL:ELR59683.1}, and yakQH1
RC   {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
RN   [2] {ECO:0000313|EMBL:MXQ96899.1, ECO:0000313|Proteomes:UP000322234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WY2019 {ECO:0000313|EMBL:MXQ96899.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:MXQ96899.1};
RA   Liu Y.;
RT   "The sequence and de novo assembly of the wild yak genome.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC   -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC       Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR   EMBL; JH880690; ELR59683.1; -; Genomic_DNA.
DR   EMBL; VBQZ03000176; MXQ96899.1; -; Genomic_DNA.
DR   RefSeq; XP_005891215.1; XM_005891153.2.
DR   AlphaFoldDB; L8IUK1; -.
DR   STRING; 72004.ENSBMUP00000026582; -.
DR   Ensembl; ENSBMUT00000030610; ENSBMUP00000026582; ENSBMUG00000019970.
DR   GeneID; 102282528; -.
DR   KEGG; bom:102282528; -.
DR   CTD; 2162; -.
DR   OrthoDB; 5344745at2759; -.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   Proteomes; UP000322234; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR   GO; GO:0072378; P:blood coagulation, fibrin clot formation; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   PANTHER; PTHR11590:SF42; COAGULATION FACTOR XIII A CHAIN; 1.
DR   PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT   DOMAIN          307..400
FT                   /note="Transglutaminase-like"
FT                   /evidence="ECO:0000259|SMART:SM00460"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        315
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT   ACT_SITE        374
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT   ACT_SITE        397
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT   BINDING         437
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT   BINDING         439
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT   BINDING         486
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT   BINDING         491
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ   SEQUENCE   732 AA;  82731 MW;  C6BBE8B7D374D697 CRC64;
     MSESSGTAFG GRRAIPPNTS NAAENDPPTV ELQGLVPRGF NPQDYLNVTN VHLFKERWDS
     NKVDHHTDKY SNDKLIVRRG QSFYIQIDFN RPYDPRRDLF RVEYVIGLYP QENKGTYIPV
     PLVSELQSGK WGAKVVMRED RSVRLSVQSS ADCIVGKFRM YVAVWTPYGV IRTSRNPETD
     TYILFNPWCE EDAVYLENEK EREECVLNDI GVIFYGDFND IKSRSWSYGQ FEDSILDACL
     FVMDKANMDL SGRGNPIKVS RVGSAMINAK DDEGVIAGSW DNVYAYGVPP SAWTGSVDIL
     LEYKSSQKPV RYGQCWVFAG VFNTFLRCLG IPARVVTNYF SAHDNDANLQ LDIFLEEDGN
     VNSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQVVDSTP QENSDGMYRC GPASVQAIKH
     GHVCFQFDAP FVFAEVNSDL VYVTAKKDGT HVVEALDTTH IGKLIVTKEI GGDGMKDITD
     TYKFQEGQEE ERLALETAMM YGAKKALNTE GVLKSKSDVR MNFEVENAVL GRDLKVIITF
     RNNGSARYTV TAYLSGNISF YTGVSKAEFK NETFEVTLEP LSFKREEVLI GAGEYMGQLL
     EQAFLHFFVT ARVNETRDVL AKQKSIALTV PKVVIKVRGA QVVGSDMVVT VEFTNPLKET
     LRNVWIRLDG PGVTKPLRKM FREIRPNSTV QWEELCRPWV SGPRKLIASL TSDSLRHVYG
     ELDLQIQRRP SM
//