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Protein

Tubulin alpha chain

Gene

ACA1_092650

Organism
Acanthamoeba castellanii str. Neff
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
Gene namesi
ORF Names:ACA1_092650Imported
OrganismiAcanthamoeba castellanii str. NeffImported
Taxonomic identifieri1257118 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba
Proteomesi
  • UP000011083 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:ACA1_092650

Subcellular locationi

  • cytoskeleton SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 245TubulinInterPro annotationAdd BLAST198
Domaini247 – 392Tubulin_CInterPro annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili417 – 437Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK07374

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

L8GIC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREIISLHL GQAGVQVGNA CWELYCLEHG IQSDGTLLPG RTESKAGLST
60 70 80 90 100
FFDETSSGKY VPRAVHFDLE PSVIDQIRSG SMAKLYHPDQ LLNTYEDAAN
110 120 130 140 150
NYARGHYTVG KEHVEMVSER VRKLAEQCDG LQGFFLFHSV GGGTGSGFGS
160 170 180 190 200
LLLERLSVDF HKKSKLDFCV FPSPQVSTSV VEPYNAVLST HSLLEHTDVA
210 220 230 240 250
FMLDNEAIYD ICKTRLNVER PTYSNLNRLI AQVISSLTAS LRFEGALNID
260 270 280 290 300
INEFQVNLVP YPRIHFLLCS YAPIIGAAKV DRERLSVAEL TSAAFDPSSM
310 320 330 340 350
MAKCDPRHGK YIAVCMMYRG DIVPKDVQAS IAKIKTSKTV QFVDWCPTGF
360 370 380 390 400
KCGVNKEPPT AVPGGDLAKV PRACCMLSNS TAIAEVFSRI DHKFDLMFAK
410 420 430 440 450
RAFVHWYVGE GMEEGEFSEA REDIAALEKD YEELGLDTVD DSMANMTDLS
460
DESSVVGSEI
Length:460
Mass (Da):50,763
Last modified:April 3, 2013 - v1
Checksum:iA93629029ADC29F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB008103 Genomic DNA Translation: ELR12732.1
RefSeqiXP_004334745.1, XM_004334697.1

Genome annotation databases

EnsemblProtistsiELR12732; ELR12732; ACA1_092650
GeneIDi14913442
KEGGiacan:ACA1_092650

Similar proteinsi

Entry informationi

Entry nameiL8GIC4_ACACA
AccessioniPrimary (citable) accession number: L8GIC4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: February 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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