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Protein
Submitted name:

Tyrosinase

Gene

TYR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported
LigandMetal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TyrosinaseImported (EC:1.14.18.1Imported)
Submitted name:
Tyrosinase (Oculocutaneous albinism IA), isoform CRA_aImported
Gene namesi
Name:TYRImported
ORF Names:hCG_19690Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000077498.8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei474 – 500HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501410125718 – 529Sequence analysisAdd BLAST512

Expressioni

Gene expression databases

BgeeiENSG00000077498.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 219Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini383 – 394Tyrosinase_Cu-bdInterPro annotationAdd BLAST12

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEZU. Eukaryota.
ENOG410Y42I. LUCA.
KOiK00505.
OMAiSFFSSWQ.
OrthoDBiEOG091G03YR.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiView protein in InterPro
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
PfamiView protein in Pfam
PF00264. Tyrosinase. 1 hit.
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiView protein in PROSITE
PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

L8B082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAVLYCLL WSFQTSAGHF PRACVSSKNL MEKECCPPWS GDRSPCGQLS
60 70 80 90 100
GRGSCQNILL SNAPLGPQFP FTGVDDRESW PSVFYNRTCQ CSGNFMGFNC
110 120 130 140 150
GNCKFGFWGP NCTERRLLVR RNIFDLSAPE KDKFFAYLTL AKHTISSDYV
160 170 180 190 200
IPIGTYGQMK NGSTPMFNDI NIYDLFVWMH YYVSMDALLG GSEIWRDIDF
210 220 230 240 250
AHEAPAFLPW HRLFLLRWEQ EIQKLTGDEN FTIPYWDWRD AEKCDICTDE
260 270 280 290 300
YMGGQHPTNP NLLSPASFFS SWQIVCSRLE EYNSHQSLCN GTPEGPLRRN
310 320 330 340 350
PGNHDKSRTP RLPSSADVEF CLSLTQYESG SMDKAANFSF RNTLEGFASP
360 370 380 390 400
LTGIADASQS SMHNALHIYM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW
410 420 430 440 450
LRRHRPLQEV YPEANAPIGH NRESYMVPFI PLYRNGDFFI SSKDLGYDYS
460 470 480 490 500
YLQDSDPDSF QDYIKSYLEQ ASRIWSWLLG AAMVGAVLTA LLAGLVSLLC
510 520
RHKRKQLPEE KQPLLMEKED YHSLYQSHL
Length:529
Mass (Da):60,393
Last modified:April 3, 2013 - v1
Checksum:i67211A91608A59E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC201429 Genomic DNA. Translation: AGV39051.1.
KC201430 Genomic DNA. Translation: AGV39052.1.
KC201431 Genomic DNA. Translation: AGV39053.1.
KC201433 Genomic DNA. Translation: AGV39055.1.
KC201434 Genomic DNA. Translation: AGV39056.1.
KC201435 Genomic DNA. Translation: AGV39057.1.
KC201436 Genomic DNA. Translation: AGV39058.1.
KC201437 Genomic DNA. Translation: AGV39059.1.
KC201438 Genomic DNA. Translation: AGV39060.1.
KC201439 Genomic DNA. Translation: AGV39061.1.
KC201440 Genomic DNA. Translation: AGV39062.1.
KC201441 Genomic DNA. Translation: AGV39063.1.
KC201442 Genomic DNA. Translation: AGV39064.1.
KC201443 Genomic DNA. Translation: AGV39065.1.
KC201444 Genomic DNA. Translation: AGV39066.1.
KC201445 Genomic DNA. Translation: AGV39067.1.
KC201446 Genomic DNA. Translation: AGV39068.1.
KC201447 Genomic DNA. Translation: AGV39069.1.
KC201448 Genomic DNA. Translation: AGV39070.1.
KC201449 Genomic DNA. Translation: AGV39071.1.
KC201450 Genomic DNA. Translation: AGV39072.1.
KC201451 Genomic DNA. Translation: AGV39073.1.
KC201452 Genomic DNA. Translation: AGV39074.1.
KC201453 Genomic DNA. Translation: AGV39075.1.
KC201454 Genomic DNA. Translation: AGV39076.1.
KC201455 Genomic DNA. Translation: AGV39077.1.
KC201456 Genomic DNA. Translation: AGV39078.1.
KC201457 Genomic DNA. Translation: AGV39079.1.
KC201458 Genomic DNA. Translation: AGV39080.1.
KC201459 Genomic DNA. Translation: AGV39081.1.
KC201463 Genomic DNA. Translation: AGV39085.1.
KC201466 Genomic DNA. Translation: AGV39088.1.
KC201471 Genomic DNA. Translation: AGV39093.1.
KC201472 Genomic DNA. Translation: AGV39094.1.
KC201475 Genomic DNA. Translation: AGV39097.1.
KC201476 Genomic DNA. Translation: AGV39098.1.
KC201477 Genomic DNA. Translation: AGV39099.1.
KC201478 Genomic DNA. Translation: AGV39100.1.
KC201479 Genomic DNA. Translation: AGV39101.1.
KC201481 Genomic DNA. Translation: AGV39103.1.
KC201483 Genomic DNA. Translation: AGV39105.1.
KC201484 Genomic DNA. Translation: AGV39106.1.
KC201485 Genomic DNA. Translation: AGV39107.1.
KC201486 Genomic DNA. Translation: AGV39108.1.
KC201487 Genomic DNA. Translation: AGV39109.1.
KC201488 Genomic DNA. Translation: AGV39110.1.
KC201489 Genomic DNA. Translation: AGV39111.1.
KC201490 Genomic DNA. Translation: AGV39112.1.
KC201491 Genomic DNA. Translation: AGV39113.1.
KC201492 Genomic DNA. Translation: AGV39114.1.
KC201493 Genomic DNA. Translation: AGV39115.1.
KC201494 Genomic DNA. Translation: AGV39116.1.
KC201495 Genomic DNA. Translation: AGV39117.1.
KC201496 Genomic DNA. Translation: AGV39118.1.
KC201497 Genomic DNA. Translation: AGV39119.1.
KC201498 Genomic DNA. Translation: AGV39120.1.
KC201499 Genomic DNA. Translation: AGV39121.1.
KC201502 Genomic DNA. Translation: AGV39124.1.
KC201503 Genomic DNA. Translation: AGV39125.1.
KC201504 Genomic DNA. Translation: AGV39126.1.
KC201505 Genomic DNA. Translation: AGV39127.1.
KC201506 Genomic DNA. Translation: AGV39128.1.
KC201507 Genomic DNA. Translation: AGV39129.1.
KC201508 Genomic DNA. Translation: AGV39130.1.
KC201509 Genomic DNA. Translation: AGV39131.1.
KC201511 Genomic DNA. Translation: AGV39133.1.
KC201512 Genomic DNA. Translation: AGV39134.1.
KC201513 Genomic DNA. Translation: AGV39135.1.
KC201514 Genomic DNA. Translation: AGV39136.1.
KC201515 Genomic DNA. Translation: AGV39137.1.
KC201516 Genomic DNA. Translation: AGV39138.1.
KC201517 Genomic DNA. Translation: AGV39139.1.
KC201518 Genomic DNA. Translation: AGV39140.1.
KC201519 Genomic DNA. Translation: AGV39141.1.
KC201520 Genomic DNA. Translation: AGV39142.1.
KC201521 Genomic DNA. Translation: AGV39143.1.
KC201522 Genomic DNA. Translation: AGV39144.1.
KC201523 Genomic DNA. Translation: AGV39145.1.
KC201524 Genomic DNA. Translation: AGV39146.1.
KC201525 Genomic DNA. Translation: AGV39147.1.
KC201526 Genomic DNA. Translation: AGV39148.1.
KC201527 Genomic DNA. Translation: AGV39149.1.
KC201528 Genomic DNA. Translation: AGV39150.1.
KC201529 Genomic DNA. Translation: AGV39151.1.
KC201530 Genomic DNA. Translation: AGV39152.1.
KC201531 Genomic DNA. Translation: AGV39153.1.
KC201532 Genomic DNA. Translation: AGV39154.1.
KC201533 Genomic DNA. Translation: AGV39155.1.
KC201534 Genomic DNA. Translation: AGV39156.1.
KC201535 Genomic DNA. Translation: AGV39157.1.
KC201536 Genomic DNA. Translation: AGV39158.1.
KC201537 Genomic DNA. Translation: AGV39159.1.
KC201538 Genomic DNA. Translation: AGV39160.1.
KC201539 Genomic DNA. Translation: AGV39161.1.
KC201541 Genomic DNA. Translation: AGV39163.1.
KC201547 Genomic DNA. Translation: AGV39169.1.
KC201552 Genomic DNA. Translation: AGV39174.1.
KC201555 Genomic DNA. Translation: AGV39177.1.
KC201556 Genomic DNA. Translation: AGV39178.1.
KC201557 Genomic DNA. Translation: AGV39179.1.
KC201558 Genomic DNA. Translation: AGV39180.1.
KC201559 Genomic DNA. Translation: AGV39181.1.
KC201560 Genomic DNA. Translation: AGV39182.1.
KC201561 Genomic DNA. Translation: AGV39183.1.
KC201562 Genomic DNA. Translation: AGV39184.1.
KC201563 Genomic DNA. Translation: AGV39185.1.
KC201564 Genomic DNA. Translation: AGV39186.1.
KC201565 Genomic DNA. Translation: AGV39187.1.
KC201567 Genomic DNA. Translation: AGV39189.1.
KC201568 Genomic DNA. Translation: AGV39190.1.
KC201569 Genomic DNA. Translation: AGV39191.1.
KC201571 Genomic DNA. Translation: AGV39193.1.
KC201573 Genomic DNA. Translation: AGV39195.1.
KC201574 Genomic DNA. Translation: AGV39196.1.
KC201575 Genomic DNA. Translation: AGV39197.1.
KC201576 Genomic DNA. Translation: AGV39198.1.
KC201577 Genomic DNA. Translation: AGV39199.1.
KC201578 Genomic DNA. Translation: AGV39200.1.
KC201579 Genomic DNA. Translation: AGV39201.1.
KC201580 Genomic DNA. Translation: AGV39202.1.
KC201581 Genomic DNA. Translation: AGV39203.1.
KC201582 Genomic DNA. Translation: AGV39204.1.
KC201583 Genomic DNA. Translation: AGV39205.1.
KC201584 Genomic DNA. Translation: AGV39206.1.
KC201585 Genomic DNA. Translation: AGV39207.1.
KC201586 Genomic DNA. Translation: AGV39208.1.
KC201587 Genomic DNA. Translation: AGV39209.1.
KC201588 Genomic DNA. Translation: AGV39210.1.
AB775900 mRNA. Translation: BAM75357.1.
CH471185 Genomic DNA. Translation: EAW59356.1.
RefSeqiNP_000363.1. NM_000372.4.
UniGeneiHs.503555.

Genome annotation databases

GeneIDi7299.
KEGGihsa:7299.

Similar proteinsi

Entry informationi

Entry nameiL8B082_HUMAN
AccessioniPrimary (citable) accession number: L8B082
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.