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Protein

Allantoinase

Gene

allB

Organism
Bacillus subtilis BEST7613
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoinase (allB)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc 1UniRule annotation1
Metal bindingi62Zinc 1UniRule annotation1
Metal bindingi147Zinc 1; via carbamate groupUniRule annotation1
Metal bindingi147Zinc 2; via carbamate groupUniRule annotation1
Metal bindingi183Zinc 2UniRule annotation1
Metal bindingi239Zinc 2UniRule annotation1
Metal bindingi312Zinc 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPurine metabolismUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Synonyms:pucHUniRule annotationImported
ORF Names:BEST7613_6379Imported
OrganismiBacillus subtilis BEST7613Imported
Taxonomic identifieri1204343 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000011218 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliL8AUN0
SMRiL8AUN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 427Amidohydro-relInterPro annotationAdd BLAST377

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG091H02CH

Family and domain databases

Gene3Di2.30.40.10, 3 hits
HAMAPiMF_01645 Hydantoinase, 1 hit
InterProiView protein in InterPro
IPR017593 Allantoinase
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR03178 allantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

L8AUN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYDMVIKGA KAVTPDGVIE ADIVVQNGVI AEIGSDIEAS GTEIIQADGK
60 70 80 90 100
YVFPGVIDCH VHFNEPGRED WEGFETGSQM MAAGGCTTYF DMPLNCIPST
110 120 130 140 150
VTAEHLLAKA ELGRQKSAVD FALWGGLVPG HIEDIRPMAE AGAIGFKAFL
160 170 180 190 200
SKSGTDEFRS VDERTLLKGM AEIAAAGKIL ALHAESDAIT SYLQMVLANK
210 220 230 240 250
GKVDADAYAA SRPEEAEVEA VYRTIQYAKV TGCPVHFVHI STAKAVRLIR
260 270 280 290 300
EAKQEGLDVS VETCPHYVLF SHDDLRQRGS VAKCAPPLRS RQSKETLIET
310 320 330 340 350
LIAGDIDMVS SDHSPCRPSL KREDNMFLSW GGISGGQFTL LGMLELALEH
360 370 380 390 400
QIPFETIAEW TAAAPAKRFG LQKKGRLEAG CDADFVLVSM EPYTVTRESM
410 420 430 440
FAKHKKSIYE GHTFPCSISA TYSKGRCVYN DGEKVTEIDG ALVVPS
Length:446
Mass (Da):48,331
Last modified:April 3, 2013 - v1
Checksum:i48515B6414A5C234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012495 Genomic DNA Translation: BAM55310.1

Genome annotation databases

EnsemblBacteriaiBAM55310; BAM55310; BEST7613_6379
PATRICifig|1148.72.peg.6918

Similar proteinsi

Entry informationi

Entry nameiL8AUN0_BACIU
AccessioniPrimary (citable) accession number: L8AUN0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: February 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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